Combined Immunodeficiency
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: Gene Transfer for Severe Combined Immunodeficiency, X-linked (SCID-X1) Using a Self-inactivating (SIN) Gammaretroviral Vector [Phase 1, Phase 2]
Phase 1/2 clinical trial results for gene transfer in X-linked severe combined immunodeficiency (SCID-X1) using a self-inactivating gammaret…
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CLINICAL_TRIALS trial_result · 2026-02-17Clinical Trial Update: Conditioning SCID Infants Diagnosed Early [Phase 2]
A Phase 2 clinical trial for conditioning in infants with severe combined immunodeficiency diagnosed early is currently active but not recru…
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CLINICAL_TRIALS trial_result · 2026-01-15Clinical Trial Update: Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies [NA]
This clinical trial investigates allogeneic hematopoietic stem cell transplantation as a treatment for primary immune deficiencies, includin…
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases [Phase 1, Phase 2]
This clinical trial update describes an early-phase study evaluating sequential cadaveric lung transplantation followed by bone marrow trans…
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CLINICAL_TRIALS trial_result · 2025-10-23Clinical Trial Update: Methadone as an Alternative Treatment for Children Underdoing HSCT [Phase 3]
Phase 3 trial evaluating methadone as an alternative treatment for children undergoing hematopoietic stem cell transplantation; the study is…
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CLINICAL_TRIALS trial_result · 2025-09-09Clinical Trial Update: SCID-X1 Gene Therapy Via Intravenous Lentiviral (Ivlv-X1) Injection [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating an intravenous lentiviral gene therapy (Ivlv-X1) for X-linked severe combined immunodeficiency (SCI…
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CLINICAL_TRIALS trial_result · 2025-07-28Clinical Trial Update: JSP191 Antibody Targeting Conditioning in SCID Patients [Phase 1, Phase 2]
Jasper Therapeutics' JSP-191 (anti-CD117 antibody) used as conditioning for hematopoietic stem cell transplantation in severe combined immun…
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CLINICAL_TRIALS trial_result · 2024-10-31Clinical Trial Update: Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant Diseases [Phase 2, Phase 3]
Clinical trial update reports Phase 2 and Phase 3 results for risk-adapted allogeneic stem cell transplantation in non-malignant diseases wi…
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CLINICAL_TRIALS trial_result · 2024-10-30Clinical Trial Update: Long Term Follow Up Of Patients Who Have Received Gene Therapy Or Gene Marked Products
Long-term follow-up results are reported for patients who received gene therapy or gene-marked products across several conditions, including…
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CLINICAL_TRIALS trial_result · 2023-09-15Clinical Trial Update: Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating conditioning regimens for allogeneic hematopoietic stem-cell transplantation has completed recruitment…
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CLINICAL_TRIALS trial_result · 2022-09-27Clinical Trial Update: Safety and Efficacy Study of Human T Lymphoid Progenitor (HTLP) Injection After Partially HLA Compatible Allogeneic Hematopoietic Stem Cell Transplantation in SCID Patients [Phase 1, Phase 2]
Clinical trial update on HTLP injection after partially HLA-compatible HSCT in SCID patients, encompassing Phase 1 and Phase 2, with unknown…
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CLINICAL_TRIALS trial_result · 2020-04-16Clinical Trial Update: EZN-2279 in Patients With ADA-SCID [Phase 3]
Phase 3 trial update for EZN-2279 in ADA-SCID has completed; results posted in 2020.
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CLINICAL_TRIALS trial_result · 2017-09-18Clinical Trial Update: SCID Bu/Flu/ATG Study With T Cell Depletion [Phase 1, Phase 2]
Phase 1/2 trial update for SCID using Bu/Flu/ATG with T cell depletion; study terminated with posted results.
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Stem Cell Gene Therapy to Treat X-Linked Severe Combined Immunodeficiency (XSCID) [Phase 1]
Phase 1 clinical trial update for a stem cell gene therapy targeting X-linked severe combined immunodeficiency. The study status indicates t…
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Influences on Female Adolescents' Decisions Regarding Testing for Carrier Status of XSCID
Clinical trial update on a NHGRI-funded study evaluating how female adolescents decide whether to pursue carrier testing for X-linked severe…
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CLINICAL_TRIALS trial_result · 2016-06-17Clinical Trial Update: Related Hematopoietic Stem Cell Transplantation (HSCT) for Genetic Diseases of Blood Cells [Phase 2]
Phase 2 study evaluating related hematopoietic stem cell transplantation for several genetic blood disorders; the trial was terminated and r…
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CLINICAL_TRIALS trial_result · 2016-05-30Clinical Trial Update: MND-ADA Transduction of CD34+ Cells From Children With ADA-SCID [Phase 2]
Phase 2 trial evaluating MND-ADA transduction of CD34+ cells in children with ADA-SCID has completed with results posted in 2016.
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CLINICAL_TRIALS trial_result · 2016-04-14Clinical Trial Update: Cord Blood Stem Cell Transplantation Study (COBLT) [Phase 2]
Phase 2 COBLT cord blood stem cell transplantation trial sponsored by NHLBI has completed, studying transplantation for aplastic anemia, Fan…
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CLINICAL_TRIALS trial_result · 2014-11-10Clinical Trial Update: Hematopoietic Stem Cell Transplantation (HSCT) for Children With SCID Utilizing Alemtuzumab, Plerixafor & Filgrastim [Phase 2]
A Phase 2 hematopoietic stem cell transplantation trial in children with severe combined immunodeficiency using alemtuzumab, plerixafor, and…
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CLINICAL_TRIALS trial_result · 2013-07-02Clinical Trial Update: Allogeneic SCT Of Pts With SCID And Other Primary Immunodeficiency Disorders [Phase 1, Phase 2]
This clinical trial update reports on allogeneic stem cell transplantation in patients with severe combined immunodeficiency and other prima…
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CLINICAL_TRIALS trial_result · 2012-07-16Clinical Trial Update: Newborn Screening for Severe Combined Immunodeficiency (SCID) in a High-Risk Population
This clinical trial update reports completion of a newborn screening program for severe combined immunodeficiency (SCID) in a high-risk popu…
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CLINICAL_TRIALS trial_result · 2009-10-15Clinical Trial Update: Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies [NA]
This clinical trial update notes termination of an allogeneic bone marrow transplantation study for patients with primary immunodeficiencies…
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CLINICAL_TRIALS trial_result · 2009-09-25Clinical Trial Update: Rapid Infusion of Immune Globulin Intravenous (Human) In Primary Immunodeficiency Patients [Phase 3]
A Phase 3 trial assessing rapid infusion of intravenous immunoglobulin (IVIG) in patients with primary immunodeficiency has completed.
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CLINICAL_TRIALS trial_result · 2009-06-30Clinical Trial Update: IMM 0212: Busulfan With Fludarabine and Antithymocyte Globulin as Preparative Therapy for Hematopoietic Stem Cell Transplant for the Treatment of Severe Congenital T-Cell Immunodeficiency [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial (IMM 0212) evaluated a busulfan with fludarabine and antithymocyte globulin preparative regimen before hema…
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CLINICAL_TRIALS trial_result · 2009-05-20Clinical Trial Update: Transplantation of Hematopoietic Cells in Children With Severe Combined Immunodeficiency Syndrome [Phase 1]
Phase 1 clinical trial update on transplantation of hematopoietic cells in children with Severe Combined Immunodeficiency. The trial is spon…