Medulloblastoma
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: 131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma [Phase 2]
An update on an ongoing Phase 2 clinical trial evaluating 131I-Omburtamab for recurrent Medulloblastoma and recurrent Ependymoma. The trial …
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults [Phase 1]
Stanford is conducting a Phase 1 study of GPC2-CAR T cell therapy for relapsed or refractory medulloblastoma and related CNS embryonal tumor…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour [Phase 3]
A Phase 3 clinical trial is investigating whether metformin improves behavior and brain function in children treated for medulloblastoma, an…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors [Phase 1]
Clinical trial update indicating that Loc3CAR (B7-H3-CAR T cells) delivery is in early-phase pediatric CNS tumor trials and currently recrui…
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease [Phase 1, Phase 2]
Clinical trial update describing a Phase 1/2 study of liothyronine in combination with the BIT regimen for medulloblastoma, with or without …
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer [Phase 1]
A Phase 1 trial evaluating the safety of a chemo-immunotherapy combo of ibrutinib and indoximod in pediatric brain tumor patients, including…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Comparison of Neurocognitive Outcome in Two Standard Regimen for Treatment of Low-risk Medulloblastoma [Phase 3]
A Phase 3 clinical trial compares two standard regimens for treating low-risk medulloblastoma, focusing on neurocognitive outcomes. The stud…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms [Phase 1]
Phase I trial update indicates ONC206 is being studied for recurrent and rare primary central nervous system neoplasms and the study is curr…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors [Phase 1]
Phase 1 trial evaluating locoregional HER2-targeted CAR T-cell therapy for pediatric recurrent or refractory central nervous system tumors a…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Medulloblastoma Online Video-based Exercise Pilot Study [NA]
The document reports a recruiting pilot study evaluating an online video-based exercise program for children with medulloblastoma.
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Multicenter Register for Children and Young Adults With Intracranial Localized Medulloblastoma, CNS-PNET or Ependymoma
A multicenter registry for children and young adults with intracranial localized medulloblastoma, CNS primitive neuroectodermal tumor, or ep…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma [Phase 2, Phase 3]
This entry reports the status of the SIOP PNET5 medulloblastoma trial (Phase 2/3) for pediatric brain tumors, currently ACTIVE_NOT_RECRUITIN…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: 68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors. [Phase 4]
A Phase 4 clinical trial evaluating the use of the radiotracer 68-Gallium DOTATATE PET/MRI for diagnosing and managing somatostatin receptor…
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CLINICAL_TRIALS research · 2025-11-13Clinical Trial Update: A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma [Phase 2]
Phase 2 clinical trial investigating a clinical and molecular risk-directed therapy for newly diagnosed medulloblastoma; status is ACTIVE_NO…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors [Phase 1]
Phase 1 study evaluating flavored oral irinotecan VAL-413 (Orotecan) with temozolomide for recurrent pediatric solid tumors is currently rec…
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: Atovaquone Combined With Radiation in Children With Malignant Brain Tumors [Phase 1]
A Phase 1 clinical trial evaluating atovaquone in combination with radiation for pediatric malignant brain tumors is currently recruiting.
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Fimepinostat in Treating Brain Tumors in Children and Young Adults [EARLY_Phase 1]
This is an early-phase 1 trial update on fimepinostat for pediatric and young adult brain tumors, including DIPG, recurrent anaplastic astro…
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CLINICAL_TRIALS research · 2025-07-09Clinical Trial Update: PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma [Phase 1]
Phase 1 clinical trial update for PEP-CMV in recurrent medulloblastoma and malignant glioma.
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CLINICAL_TRIALS research · 2025-06-17Clinical Trial Update: A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. [EARLY_Phase 1]
An early-phase trial evaluating TP53 cDNA gene therapy combined with checkpoint inhibition and radiation in children with recurrent or refra…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Novel Molecular Targets and Innovative Therapeutic Perspective in Medulloblastoma [EARLY_Phase 1]
This clinical trial update describes an early-phase 1 study in pediatric medulloblastoma investigating novel molecular targets and innovativ…
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: Systemic Biomarkers to Predict Radiation-Induced Neurocognitive Decline
A Tata Memorial Centre study is investigating systemic biomarkers to predict radiation-induced neurocognitive decline in patients with brain…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: Focal Radiotherapy Plus Low Dose Craniospinal Irradiation Followed by Adjuvant Chemotherapy in WNT Medulloblastoma. [NA]
A clinical trial evaluating focal radiotherapy with low-dose craniospinal irradiation followed by adjuvant chemotherapy for WNT-activated me…
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CLINICAL_TRIALS research · 2025-03-25Clinical Trial Update: Integrated Analysis of Therapy Response and Resistence in Embryonal Tumors and Gliomas
This clinical trial update outlines an integrated analysis of how embryonal tumors and gliomas respond to therapy and develop resistance, in…
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CLINICAL_TRIALS research · 2025-02-12Clinical Trial Update: Accurate Diagnosis and Grading of Pediatric Solid Tumors Based on Pathological Large Models
A clinical trial from Xinhua Hospital and Shanghai Jiao Tong University aims to improve diagnosis and grading of pediatric solid tumors usin…
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CLINICAL_TRIALS research · 2025-02-07Clinical Trial Update: Intraoperatively Observed Site of Origin and Growth Pattern of Medulloblastoma
This document updates an ongoing clinical study examining the intraoperative origin site and growth pattern of medulloblastoma. Recruitment …