Low-grade Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy [Phase 2]
A Phase 2 pediatric trial is evaluating a MEK inhibitor versus chemotherapy for pediatric low-grade gliomas, including Grade 1 glioma and mi…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Implantable Microdevice In Primary Brain Tumors [EARLY_Phase 1]
An early Phase 1 clinical trial evaluating an implantable microdevice for primary brain tumors is currently recruiting across multiple gliom…
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CLINICAL_TRIALS trial_result · 2025-07-18Clinical Trial Update: ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas [Phase 1]
Phase 1 clinical trial update for Vorasidenib in combination with a tumor-specific peptide vaccine in recurrent IDH1-mutant lower-grade glio…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: LIQUID BIOPSY IN Low-grade Glioma Patients [NA]
Clinical trial evaluating liquid biopsy for patients with low-grade glioma is currently Recruiting at University Hospital, Montpellier.
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CLINICAL_TRIALS trial_result · 2025-06-17Clinical Trial Update: SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain Tissue [NA]
SonoClear is reporting completion of its clinical trial evaluating Acoustic Coupling Fluid (ACF) for brain-tissue–mimicking use in condition…
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CLINICAL_TRIALS trial_result · 2025-06-04Clinical Trial Update: FCN-159 Monotherapy Versus Chemotherapy by Investigator's Choice in Pediatric Low-grade Glioma Patients With BRAF Alteration [Phase 3]
This Phase 3 trial compares FCN-159 monotherapy with investigator's-choice chemotherapy for pediatric low-grade glioma with BRAF alterations…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation [Phase 2]
Phase 2 clinical trial evaluating proton radiotherapy for pediatric brain tumors requiring partial brain irradiation has completed enrollmen…
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CLINICAL_TRIALS research · 2025-05-29Clinical Trial Update: MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/Phase 2 study exploring a MAPK pathway inhibitor in combination with anti-PD1 therapy for BRA…
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CLINICAL_TRIALS research · 2025-05-15Clinical Trial Update: Pilot Study of Vinblastine and Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Grade Gliomas [EARLY_Phase 1]
Pediatric pilot study combining vinblastine with tovorafenib for recurrent/RAF-altered low-grade gliomas is in early-phase recruitment.
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CLINICAL_TRIALS research · 2025-04-10Clinical Trial Update: A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors [Phase 2]
A Phase 2 clinical trial evaluating tovorafenib in pediatric and young adult participants with relapsed or progressive low-grade glioma and …
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CLINICAL_TRIALS trial_result · 2025-03-21Clinical Trial Update: A Phase II Trial of Poly-ICLC for Low-Grade Gliomas [Phase 2]
A terminated Phase II trial evaluating poly-ICLC for low-grade gliomas in NF1 patients has posted results.
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CLINICAL_TRIALS trial_result · 2025-01-15Clinical Trial Update: Feasibility of the LUM Imaging System for Detection of Cancer to the Brain [NA]
A feasibility trial of the LUM Imaging System for detecting cancer in the brain has been terminated.
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CLINICAL_TRIALS research · 2025-01-08Clinical Trial Update: HyperSpectral Imaging in Low Grade Glioma [NA]
Clinical trial update indicates active recruitment for a study evaluating HyperSpectral Imaging in patients with low-grade glioma.
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CLINICAL_TRIALS trial_result · 2024-12-16Clinical Trial Update: BGB-290 and Temozolomide in Treating Patients With Recurrent Gliomas With IDH1/2 Mutations [Phase 1, Phase 2]
This clinical trial update reports results from a Phase 1/2 study of BGB-290 in combination with temozolomide in patients with recurrent gli…
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CLINICAL_TRIALS trial_result · 2024-12-06Clinical Trial Update: A Pilot Study of Glioma Associated Antigen Vaccines in Conjunction with Poly-ICLC in Pediatric Gliomas [Phase 1]
This Phase 1 pilot trial evaluated glioma-associated antigen vaccines with the Toll-like receptor 3 agonist Poly-ICLC in pediatric gliomas a…
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CLINICAL_TRIALS research · 2024-11-26Clinical Trial Update: A Study Comparing Two Carboplatin Containing Regimens for Children and Young Adults With Previously Untreated Low Grade Glioma [Phase 3]
A Phase 3 clinical trial comparing two carboplatin-containing regimens for newly diagnosed low-grade glioma in children and young adults, cu…
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CLINICAL_TRIALS research · 2024-11-12Clinical Trial Update: FG001 in Subjects with Meningiomas or Presumed Low-Grade Gliomas Scheduled for Neurosurgery [Phase 2]
A Phase 2 clinical trial evaluating FG001 in patients with meningioma or low-grade glioma is currently recruiting for neurosurgical studies.
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CLINICAL_TRIALS research · 2024-09-24Clinical Trial Update: Monitoring of Patients With Low-grade Gliomas Using Circulating miRNA
A recruiting study evaluating circulating microRNA as biomarkers to monitor patients with low-grade gliomas.
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CLINICAL_TRIALS approval · 2024-08-12Clinical Trial Update: Expanded Access Program (EAP) for Tovorafenib (DAY101) in RAF-Altered, Relapsed or Refractory Low-Grade Glioma
Tovorafenib (DAY101) has been approved for marketing for RAF-altered, relapsed or refractory low-grade glioma, with an Expanded Access Progr…
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CLINICAL_TRIALS research · 2024-07-15Clinical Trial Update: Surgical Management of Low Grade Glioma
A clinical trial update for study NCT06499922 on surgical management of low-grade glioma, currently not recruiting.
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CLINICAL_TRIALS trial_result · 2024-07-09Clinical Trial Update: Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma [Phase 2, Phase 3]
A completed Phase 2/3 trial evaluating observation or radiation therapy with or without combination chemotherapy for low-grade glioma.
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CLINICAL_TRIALS trial_result · 2024-07-03Clinical Trial Update: Evaluation of the Correlation Between Molecular Phenotype and Radiological Signature (by PET-scanner and MRI) of Incident WHO II and III Grade Gliomas.
A completed study evaluating the relationship between molecular phenotype and radiological features on PET and MRI in patients with incident…
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CLINICAL_TRIALS trial_result · 2024-06-14Clinical Trial Update: A Study of Varlilumab and IMA950 Vaccine Plus Poly-ICLC in Patients With WHO Grade II Low-Grade Glioma (LGG) [Phase 1]
Phase 1 trial evaluating varlilumab in combination with the IMA950 vaccine and Poly-ICLC in adults with WHO grade II low-grade glioma; the s…
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CLINICAL_TRIALS trial_result · 2024-04-25Clinical Trial Update: Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial) [Phase 2]
A pediatric MATCH phase 2 trial assessed olaparib in children with relapsed or refractory advanced solid tumors or non-Hodgkin lymphoma carr…
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FDA approval · 2024-04-23FDA Approved: OJEMDA — Original Application (Day One Biopharmaceuticals, Inc.)
FDA approved OJEMDA (tovorafenib) from Day One Biopharmaceuticals as a new drug for the treatment of patients with low-grade glioma.