Langerhans Cell Histiocytosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial) [Phase 2]
Phase 2 update from the Pediatric MATCH trial describes targeted therapies matched to tumor genetics in pediatric patients with relapsed or …
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis [Phase 2, Phase 3]
The LCH-IV international collaborative treatment protocol for children and adolescents with Langerhans cell histiocytosis is described, span…
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CLINICAL_TRIALS trial_result · 2026-03-25Clinical Trial Update: Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 pediatric MATCH trial evaluating IDH1-mutant tumors for response to ivosidenib; results for recurrent and refractory solid tumors, l…
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers. [Phase 2, Phase 3]
The DETERMINE trial's Arm 07 is studying dabrafenib plus trametinib in patients with BRAF V600 mutation-positive cancers across age groups; …
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CLINICAL_TRIALS trial_result · 2026-02-20Clinical Trial Update: Molecular Basis of Langerhans and Non-Langerhans Cell Histiocytic Neoplasms and Castleman Disease [NA]
A clinical trial update indicates a study examining the molecular basis of Castleman disease, Langerhans cell histiocytosis, and non-Langerh…
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CLINICAL_TRIALS trial_result · 2025-11-06Clinical Trial Update: Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial [Phase 2]
This update reports on a Phase 2 pediatric MATCH trial evaluating selpercatinib for patients with activating RET gene alterations across adv…
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CLINICAL_TRIALS trial_result · 2025-06-11Clinical Trial Update: Histiocytic Disorder Follow-up Study
A University of Alabama at Birmingham-sponsored clinical trial update indicates recruiting for a histiocytic disorder follow-up study, inclu…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial [Phase 2]
Phase 2 pediatric MATCH trial results for Tipifarnib in HRAS-altered solid tumors and histiocytic disorders; the study has posted results an…
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CLINICAL_TRIALS trial_result · 2025-04-25Clinical Trial Update: Lenalidomide for Adult Histiocyte Disorders [Phase 2]
Phase 2 trial results of lenalidomide in adults with Langerhans cell histiocytosis, Erdheim-Chester disease, and histiocytic sarcoma; the st…
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CLINICAL_TRIALS trial_result · 2024-09-04Clinical Trial Update: Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 Pediatric MATCH trial evaluating samotolisib in pediatric patients with relapsed or refractory tumors harboring TSC or PI3K/mTOR mut…
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CLINICAL_TRIALS trial_result · 2023-09-13Clinical Trial Update: Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
This Phase 2 Pediatric MATCH trial evaluated vemurafenib in children with BRAF V600-mutant relapsed or refractory advanced solid tumors, non…
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CLINICAL_TRIALS trial_result · 2023-08-08Clinical Trial Update: The Efficacy and Safety of HLX208 in Adult Langerhans Cell Histiocytosis (LCH) and Erdheim-Chester Disease (ECD) With BRAF V600E Mutation [Phase 2]
Phase 2 clinical trial evaluating HLX208 for adult Langerhans Cell Histiocytosis and Erdheim-Chester Disease with BRAF V600E mutation; curre…
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CLINICAL_TRIALS trial_result · 2023-05-16Clinical Trial Update: Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 Pediatric MATCH trial evaluating Ulixertinib for MAPK-pathway-mutant tumors in children, including advanced solid tumors, Non-Hodgki…
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CLINICAL_TRIALS trial_result · 2023-04-27Clinical Trial Update: Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
This Phase 2 pediatric MATCH trial update reports results for tazemetostat in patients with relapsed or refractory solid tumors, non-Hodgkin…
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CLINICAL_TRIALS trial_result · 2023-03-16Clinical Trial Update: A Combination of Vemurafenib, Cytarabine and 2-chlorodeoxyadenosine in Children With LCH and BRAF V600E Mutation [Phase 2]
Phase 2 trial evaluating a combination of vemurafenib, cytarabine, and 2-chlorodeoxyadenosine in children with Langerhans Cell Histiocytosis…
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CLINICAL_TRIALS trial_result · 2022-07-26Clinical Trial Update: A Prospective Study for the Treatment of Children With Newly Diagnosed LCH Using a Cytarabine Contained Protocol [Phase 3]
A Phase 3 prospective trial evaluating a cytarabine-containing protocol for newly diagnosed Langerhans Cell Histiocytosis in children, curre…
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CLINICAL_TRIALS trial_result · 2022-03-17Clinical Trial Update: Central China Rosai-Dorfman Disease Registry [Phase 4]
A Phase 4 clinical trial update for Rosai-Dorfman Disease registry in Central China; status is currently unknown.
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CLINICAL_TRIALS trial_result · 2022-02-16Clinical Trial Update: Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis and LCH-related Disorders [Phase 2]
Phase 2 clinical trial update on clofarabine for recurrent or refractory Langerhans cell histiocytosis with results posted.
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CLINICAL_TRIALS trial_result · 2021-06-08Clinical Trial Update: AraC for Newly Diagnosed Adult Langerhans Cell Histiocytosis [Phase 2]
Phase 2 trial update for AraC in newly diagnosed adult Langerhans Cell Histiocytosis.
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CLINICAL_TRIALS trial_result · 2021-06-08Clinical Trial Update: Thalidomide, Cyclophosphamide and Dexamethasone for Recurrent/Refractory Adult Langerhans Cell Histiocytosis [Phase 2]
Phase 2 clinical trial evaluating thalidomide, cyclophosphamide, and dexamethasone for recurrent/refractory adult Langerhans Cell Histiocyto…
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CLINICAL_TRIALS trial_result · 2020-09-09Clinical Trial Update: A Study to Test the Ability of and Safety of GSK2110183 in Treating Langerhans Cell Histiocytosis [Phase 2]
A Phase 2 trial evaluating the efficacy and safety of GSK2110183 for Langerhans Cell Histiocytosis has completed.
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CLINICAL_TRIALS trial_result · 2020-01-09Clinical Trial Update: Treatment of Resistant Langerhans Cell Histiocytosis With ENBREL [Phase 2]
Phase 2 trial update exploring ENBREL (etanercept) for resistant Langerhans cell histiocytosis.
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CLINICAL_TRIALS trial_result · 2018-09-12Clinical Trial Update: Methotrexate and Cytosine in Adult Langerhans Cell Histiocytosis [Phase 2]
Phase 2 trial updates for methotrexate and cytosine in adult Langerhans Cell Histiocytosis.
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CLINICAL_TRIALS trial_result · 2017-04-14Clinical Trial Update: Stem Cell Transplant for Immunologic or Histiocytic Disorders [Phase 2]
Phase 2 trial update on stem cell transplantation for immunologic or histiocytic disorders, with completed status and results posted in 2017…
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CLINICAL_TRIALS trial_result · 2015-11-03Clinical Trial Update: Reduced Intensity Hematopoietic Cell Transplantation for Patients With Resistant Langerhans Cell Histiocytosis [Phase 2]
Phase 2 trial update on reduced intensity hematopoietic cell transplantation for patients with resistant Langerhans cell histiocytosis has b…