CLINICAL_TRIALS ClinicalTrials.gov record update

DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial): An Umbrella-Basket Platform Trial to Evaluate the Efficacy of Targeted Therapies in Rare Adult, Paediatric and Teenage/Young Adult (TYA) Cancers With Actionable Genomic Alterations, Including Common Cancers With Rare Actionable Alterations. Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and TYA Patients With BRAF V600 Mutation-Positive Cancers.

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Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT07440290
Title field or adapter rule: protocolSection.identificationModule.officialTitle
Ingested At: 2026-04-25T22:28:19.966983+00:00
Published At: 2026-02-27T00:00:00+00:00
Record Updated At: 2026-02-27
Timestamp Basis: source retrieval time was not retained by the feed adapter
Date limitation: source retrieval time was not retained by the feed adapter

protocolSection.conditionsModule.conditions: ["Haematological Malignancy", "Malignant Neoplasm", "Lymphoproliferative Disorders", "Neoplasms by Histologic Type", "Neoplasms by Site", "Gastrointestinal Cancer", "Non-Melanoma Skin Cancer (NMSC)", "Langerhans Cell Histiocytosis (LCH)", "Cancer", "Erdheim-Chester Disease", "Thyroid Carcinoma, Papillary", "Ovarian Neoplasms", "Colorectal Neoplasms", "Laryngeal Neoplasms", "Carcinoma, Non-Small Cell-Lung", "Glioma", "Multiple Myeloma", "Thyroid Carcinoma, Anaplastic", "Solid Tumour"]
protocolSection.statusModule.lastUpdatePostDateStruct.date: "2026-02-27"
protocolSection.identificationModule.nctId: "NCT07440290"
protocolSection.identificationModule.officialTitle: "DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial): An Umbrella-Basket Platform Trial to Evaluate the Efficacy of Targeted Therapies in Rare Adult, Paediatric and Teenage/Young Adult (TYA) Cancers With Actionable Genomic Alterations, Including Common Cancers With Rare Actionable Alterations. Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and TYA Patients With BRAF V600 Mutation-Positive Cancers."
protocolSection.statusModule.overallStatus: "NOT_YET_RECRUITING"
protocolSection.designModule.phases: ["PHASE2", "PHASE3"]
protocolSection.statusModule.resultsFirstPostDateStruct.date: ""

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