Langerhans Cell Histiocytosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis [Phase 2]
This clinical trial update describes a Phase 2 study of tovorafenib (DAY101) as a potential treatment for progressive, relapsed, or refracto…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial) [Phase 2]
This update reports on a Phase 2 pediatric MATCH trial evaluating ensartinib for patients with relapsed or refractory ALK- or ROS1-genomic a…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Targeted Approach to Langerhans Cell Histiocytosis (LCH) Using MEK Inhibitor, Trametinib [Phase 2]
A Phase 2 clinical trial is evaluating trametinib, a MEK inhibitor, as a targeted treatment for Langerhans Cell Histiocytosis and is current…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Optimization of the Time and Dosage of Vemurafenib in BRAF Positive Juvenile Patients With Refractory Histiocytosis [Phase 2]
An ongoing Phase 2 trial is evaluating and optimizing the timing and dosing of vemurafenib in juvenile patients with BRAF V600E–positive ref…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Project: Every Child for Younger Patients With Cancer
Clinical trial update from the Children's Oncology Group shows that the multi-indication pediatric trial 'Project: Every Child for Younger P…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Modified LCH-III Regimen With or Without Luvometinib for Multisystem Pediatric Langerhans Cell Histiocytosis [NA]
A clinical trial update indicates status is recruiting for a study of Modified LCH-III regimen with or without Luvometinib in pediatric mult…
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: Luvometinib in Pediatric SS-LCH With Special-site Single/Multifocal Bone Lesions [NA]
A pediatric clinical trial is evaluating Luvometinib for Langerhans Cell Histiocytosis with special-site single/multifocal bone lesions; the…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Inherited Genetic Susceptibility in Langerhans Cell Histiocytosis (LCH)
Clinical trial update indicating inherited genetic susceptibility in Langerhans cell histiocytosis (LCH); the study is currently active but …
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CLINICAL_TRIALS research · 2025-10-10Clinical Trial Update: Q702 for the Treatment of Patients With Hematologic Malignancies [Phase 1]
This entry notes a Phase 1 clinical trial (Q702) for hematologic malignancies led by Mayo Clinic, currently recruiting and including histioc…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Efficacy and Safety of XTD Regimen (Selinexor, Thalidomide and Dexamethasone) in Adult Patients With Relapsed/Refractory LCH [Phase 2]
Phase 2 clinical trial evaluating the efficacy and safety of the XTD regimen (Selinexor, Thalidomide, and Dexamethasone) in adults with rela…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Efficacy and Safety of Low-Dose Cytarabine Combined With Thalidomide in Adult Patients With Untreated LCH [Phase 2]
A Phase 2 clinical trial is evaluating the efficacy and safety of combining low-dose cytarabine with thalidomide in adults with untreated La…
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders [Phase 2]
Phase 2 clinical trial update evaluating cobimetinib in refractory Langerhans cell histiocytosis and other histiocytic disorders, currently …
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Mirdametinib in Histiocytic Disorders [Phase 2]
Phase 2 clinical trial evaluating mirdametinib for histiocytic disorders including Langerhans cell histiocytosis, Juvenile xanthogranuloma, …
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell Histiocytosis (LCH) [Phase 3]
A Phase 3 clinical trial comparing vinblastine plus prednisone versus cytarabine alone for Langerhans cell histiocytosis is currently recrui…
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation [Phase 1, Phase 2]
This document provides an update on a phase 1/2 clinical trial evaluating CD34+ stem cell selection for patients receiving allogeneic stem c…
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CLINICAL_TRIALS research · 2025-06-15Clinical Trial Update: Real-world Study of Darafenib or Trametinib and Clofarabine for High-risk/Recurrent/Refractory Langerhans Cell Histiocytosis in Children [Phase 2]
A Phase 2 clinical trial is evaluating the combination of Darafenib or Trametinib with Clofarabine for high-risk, recurrent, or refractory L…
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CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: Adebrelimab Combined With Trametinib in the Treatment of Refractory Recurrent Langerhans Cell Histiocytosis in Children and Adolescents [Phase 1]
A Phase 1 clinical trial evaluating the combination of adebrelimab and trametinib for refractory recurrent Langerhans cell histiocytosis in …
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CLINICAL_TRIALS research · 2025-01-24Clinical Trial Update: To Evaluate the Efficacy, Safety, and PK Characteristics of FCN-159 in Pediatric Patients With Refractory/Recurrent LCH [Phase 2]
This clinical trial update notes a Phase 2 study evaluating FCN-159 in pediatric patients with refractory or recurrent Langerhans cell histi…
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CLINICAL_TRIALS research · 2025-01-15Clinical Trial Update: Denosumab for the Treatment of Adult LCH [Phase 2]
Clinical trial update noting completion of a Phase 2 study evaluating denosumab for adult Langerhans cell histiocytosis.
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CLINICAL_TRIALS research · 2024-07-17Clinical Trial Update: Biomarkers for Diagnostic, Prognostic and of Response to Treatment in Adult Langerhans Cell Histiocytosis
This clinical trial update describes ongoing research into biomarkers for diagnosing, prognosticating, and assessing treatment response in a…
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CLINICAL_TRIALS research · 2007-06-08Clinical Trial Update: Cardiovascular Risk Factors and LCH in Adults
Clinical trial update focusing on cardiovascular risk factors in adults with Langerhans cell histiocytosis; current status of the study is U…