NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)- Phase 2 Subprotocol of Tipifarnib in Patients With Tumors Harboring HRAS Genomic Alterations

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT04284774

Title field or adapter rule

protocolSection.identificationModule.officialTitle

Ingested At

2026-04-25T22:28:53.320720+00:00

Published At

2025-06-03T00:00:00+00:00

Record Updated At

2025-12-04

Results Posted At

2025-06-03

Timestamp Basis

source retrieval time was not retained by the feed adapter

Date limitation

source retrieval time was not retained by the feed adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Malignant Solid Neoplasm", "Recurrent Adrenal Gland Pheochromocytoma", "Recurrent Ectomesenchymoma", "Recurrent Ependymoma", "Recurrent Ewing Sarcoma", "Recurrent Hepatoblastoma", "Recurrent Kidney Wilms Tumor", "Recurrent Langerhans Cell Histiocytosis", "Recurrent Malignant Germ Cell Tumor", "Recurrent Malignant Glioma", "Recurrent Medulloblastoma", "Recurrent Melanoma", "Recurrent Neuroblastoma", "Recurrent Non-Hodgkin Lymphoma", "Recurrent Osteosarcoma", "Recurrent Peripheral Primitive Neuroectodermal Tumor", "Recurrent Rhabdoid Tumor", "Recurrent Rhabdoid Tumor of the Kidney", "Recurrent Rhabdomyosarcoma", "Recurrent Soft Tissue Sarcoma", "Recurrent Thyroid Gland Carcinoma", "Recurrent WHO Grade 2 Glioma", "Refractory Adrenal Gland Pheochromocytoma", "Refractory Ependymoma", "Refractory Ewing Sarcoma", "Refractory Hepatoblastoma", "Refractory Langerhans Cell Histiocytosis", "Refractory Malignant Germ Cell Tumor", "Refractory Malignant Glioma", "Refractory Medulloblastoma", "Refractory Melanoma", "Refractory Neuroblastoma", "Refractory Non-Hodgkin Lymphoma", "Refractory Osteosarcoma", "Refractory Peripheral Primitive Neuroectodermal Tumor", "Refractory Rhabdoid Tumor", "Refractory Rhabdoid Tumor of the Kidney", "Refractory Rhabdomyosarcoma", "Refractory Soft Tissue Sarcoma", "Refractory Thyroid Gland Carcinoma", "Refractory WHO Grade 2 Glioma"]

protocolSection.statusModule.lastUpdatePostDateStruct.date

"2025-12-04"

protocolSection.identificationModule.nctId

"NCT04284774"

protocolSection.identificationModule.officialTitle

"NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)- Phase 2 Subprotocol of Tipifarnib in Patients With Tumors Harboring HRAS Genomic Alterations"

protocolSection.statusModule.overallStatus

"ACTIVE_NOT_RECRUITING"

protocolSection.designModule.phases

["PHASE2"]

protocolSection.statusModule.resultsFirstPostDateStruct.date

"2025-06-03"

Study condition terms

• Malignant Solid Neoplasm (protocolSection.conditionsModule.conditions)
• Recurrent Adrenal Gland Pheochromocytoma (protocolSection.conditionsModule.conditions)
• Recurrent Ectomesenchymoma (protocolSection.conditionsModule.conditions)
• Recurrent Ependymoma (protocolSection.conditionsModule.conditions)
• Recurrent Ewing Sarcoma (protocolSection.conditionsModule.conditions)
• Recurrent Hepatoblastoma (protocolSection.conditionsModule.conditions)
• Recurrent Kidney Wilms Tumor (protocolSection.conditionsModule.conditions)
• Recurrent Langerhans Cell Histiocytosis (protocolSection.conditionsModule.conditions)
• Recurrent Malignant Germ Cell Tumor (protocolSection.conditionsModule.conditions)
• Recurrent Malignant Glioma (protocolSection.conditionsModule.conditions)
• Recurrent Medulloblastoma (protocolSection.conditionsModule.conditions)
• Recurrent Melanoma (protocolSection.conditionsModule.conditions)
• Recurrent Neuroblastoma (protocolSection.conditionsModule.conditions)
• Recurrent Non-Hodgkin Lymphoma (protocolSection.conditionsModule.conditions)
• Recurrent Osteosarcoma (protocolSection.conditionsModule.conditions)
• Recurrent Peripheral Primitive Neuroectodermal Tumor (protocolSection.conditionsModule.conditions)
• Recurrent Rhabdoid Tumor (protocolSection.conditionsModule.conditions)
• Recurrent Rhabdoid Tumor of the Kidney (protocolSection.conditionsModule.conditions)
• Recurrent Rhabdomyosarcoma (protocolSection.conditionsModule.conditions)
• Recurrent Soft Tissue Sarcoma (protocolSection.conditionsModule.conditions)
• Recurrent Thyroid Gland Carcinoma (protocolSection.conditionsModule.conditions)
• Recurrent WHO Grade 2 Glioma (protocolSection.conditionsModule.conditions)
• Refractory Adrenal Gland Pheochromocytoma (protocolSection.conditionsModule.conditions)
• Refractory Ependymoma (protocolSection.conditionsModule.conditions)
• Refractory Ewing Sarcoma (protocolSection.conditionsModule.conditions)
• Refractory Hepatoblastoma (protocolSection.conditionsModule.conditions)
• Refractory Langerhans Cell Histiocytosis (protocolSection.conditionsModule.conditions)
• Refractory Malignant Germ Cell Tumor (protocolSection.conditionsModule.conditions)
• Refractory Malignant Glioma (protocolSection.conditionsModule.conditions)
• Refractory Medulloblastoma (protocolSection.conditionsModule.conditions)
• Refractory Melanoma (protocolSection.conditionsModule.conditions)
• Refractory Neuroblastoma (protocolSection.conditionsModule.conditions)
• Refractory Non-Hodgkin Lymphoma (protocolSection.conditionsModule.conditions)
• Refractory Osteosarcoma (protocolSection.conditionsModule.conditions)
• Refractory Peripheral Primitive Neuroectodermal Tumor (protocolSection.conditionsModule.conditions)
• Refractory Rhabdoid Tumor (protocolSection.conditionsModule.conditions)
• Refractory Rhabdoid Tumor of the Kidney (protocolSection.conditionsModule.conditions)
• Refractory Rhabdomyosarcoma (protocolSection.conditionsModule.conditions)
• Refractory Soft Tissue Sarcoma (protocolSection.conditionsModule.conditions)
• Refractory Thyroid Gland Carcinoma (protocolSection.conditionsModule.conditions)
• Refractory WHO Grade 2 Glioma (protocolSection.conditionsModule.conditions)

Intervention details are not present in the imported fields for this record. No drug-condition relationship is inferred from co-listing.

This index keeps the source fields it imported; it may not contain the complete original record. Verify wording and context in the linked source.