High-grade Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-12-11Clinical Trial Update: Multiparametic Metabolic and Hypoxic PET/MRI for Disease Assessment in High Grade Glioma [EARLY_Phase 1]
An early-phase study evaluating multiparametric metabolic and hypoxic PET/MRI for disease assessment in high-grade glioma. The trial is curr…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: 18F-Fluciclovine PET-MRI in High-grade Glioma [EARLY_Phase 1]
An early-phase trial evaluating 18F-Fluciclovine PET-MRI for imaging high-grade glioma is currently recruiting.
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Phase I/IIa Study of Concomitant Radiotherapy With Olaparib and Temozolomide in Unresectable High Grade Gliomas Patients [Phase 1, Phase 2]
A Phase I/IIa clinical trial is evaluating the safety and feasibility of combining radiotherapy with olaparib and temozolomide in unresectab…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors [EARLY_Phase 1]
Early-phase clinical trial studying Gallium-68 PSMA-11 PET imaging for patients with brain tumors, currently active but not recruiting.
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Study of LAM561 Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating LAM561 Acid in pediatric patients with malignant glioma and other advanced solid tumors is currently r…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions [EARLY_Phase 1]
A Phase 0/1 study of BDTX-1535 in patients with recurrent high-grade glioma and newly diagnosed glioblastoma with EGFR alterations or fusion…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: Intratumoral Extracellular Metabolic Impact of DFMO and AMXT 1501 in Patients With Diffuse or High Grade Glioma [EARLY_Phase 1]
Early-phase trial evaluating the intratumoral metabolic impact of DFMO combined with AMXT-1501 in patients with diffuse or high-grade glioma…
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: Pilot Study of Mirtazapine for the Dual Tx of Depression and CINV in High-Grade Glioma Pts on TMZ [Phase 2]
Phase 2 pilot study evaluating mirtazapine for dual treatment of depression and chemotherapy-induced nausea and vomiting in patients with hi…
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy [Phase 1]
A Phase 1 clinical trial is evaluating focused ultrasound to disrupt the blood-brain barrier in high-grade glioma patients undergoing standa…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Study of DSP-0390 in Patients With Recurrent High-Grade Glioma [EARLY_Phase 1]
DSP-0390 is being studied in an early-phase Phase 1 trial for recurrent high-grade glioma, including glioblastoma, and the study is currentl…
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CLINICAL_TRIALS research · 2025-09-04Clinical Trial Update: C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B) [Phase 1]
Phase 1 clinical trial update for C7R-GD2.CAR T cells targeting GD2-expressing brain tumors, currently recruiting for DIPG, high-grade gliom…
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CLINICAL_TRIALS research · 2025-08-29Clinical Trial Update: A Pilot Study Investigating Upfront Adaptive Immunotherapy Approach in Children, Adolescent and Young Adult (CAYA) Patients With Replication-Repair Deficient (RRD) High-Grade Gliomas (HGG) [NA]
A pilot clinical trial is investigating upfront adaptive immunotherapy for children, adolescents and young adults with replication-repair de…
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Clinical Study on the Treatment of Malignant Brain Glioma by QH104 Cell Injection [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating QH104 cell injections for malignant brain gliomas, including glioblastoma multiforme and other high-gr…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: Multi-Dimensional MRI Spatial Heterogeneity Analysis for Predicting Key Genes and Prognosis of High-Grade Gliomas: A Multi-Center Study
A multi-center clinical trial is recruiting to evaluate multi-dimensional MRI spatial heterogeneity for predicting key genes and prognosis i…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Effect H2 Water on QoL of Patients Receiving Radiotherapy for High Grade Gliomas. [Phase 2]
Phase 2 clinical trial evaluating whether hydrogen-rich water improves quality of life in patients receiving radiotherapy for high-grade mal…
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: Atovaquone Combined With Radiation in Children With Malignant Brain Tumors [Phase 1]
A Phase 1 clinical trial evaluating atovaquone in combination with radiation for pediatric malignant brain tumors is currently recruiting.
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade Glioma [Phase 1]
Phase 1 clinical trial to determine the maximum tolerated dose, safety, and tolerability of a Rhenium-186 radiopharmaceutical in pediatric p…
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CLINICAL_TRIALS research · 2025-07-09Clinical Trial Update: BC008-1A Injection for Recurrent CNS WHO G4 Glioma [Phase 1]
A Phase 1 study of BC008-1A Injection for recurrent central nervous system WHO Grade 4 glioma (including glioblastoma) is currently recruiti…
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CLINICAL_TRIALS research · 2025-06-22Clinical Trial Update: STARLITE for Unresectable High-Grade Gliomas [Phase 1]
Phase 1 trial STARLITE for unresectable high-grade gliomas is currently recruiting at the University of Miami.
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CLINICAL_TRIALS research · 2025-06-17Clinical Trial Update: A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. [EARLY_Phase 1]
An early-phase trial evaluating TP53 cDNA gene therapy combined with checkpoint inhibition and radiation in children with recurrent or refra…
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CLINICAL_TRIALS research · 2025-06-05Clinical Trial Update: 68Ga/177Lu-PSMA Theranostics in Recurrent Grade 3 and Grade 4 Glioma [NA]
This clinical trial update indicates recruitment is ongoing for a theranostic approach using 68Ga-PSMA and 177Lu-PSMA in recurrent high-grad…
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CLINICAL_TRIALS research · 2025-05-31Clinical Trial Update: A Ketogenic Diet as a Complementary Treatment on Patients With High-grade Gliomas and Brain Metastases [NA]
A clinical trial at Attikon Hospital is evaluating the ketogenic diet as a complementary treatment for patients with high-grade gliomas and …
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CLINICAL_TRIALS research · 2025-05-29Clinical Trial Update: MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/Phase 2 study exploring a MAPK pathway inhibitor in combination with anti-PD1 therapy for BRA…
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CLINICAL_TRIALS research · 2025-05-16Clinical Trial Update: Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) in Glioma (WHO G3-G4) Progression [NA]
This entry notes that recruitment is ongoing for a local alpha-emitter therapy, [225Ac]Ac-DOTA-SP (TAT), being studied for glioblastoma and …
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CLINICAL_TRIALS research · 2025-05-13Clinical Trial Update: Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells [Phase 1]
Phase 1 study to evaluate locoregional injections of ex vivo expanded natural killer cells in patients with high-grade glioma.