Hemophagocytic Lymphohistiocytosis
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: Efficacy and Safety of Interferon-Gamma Monoclonal Antibody Combined With Dexamethasone in the Treatment of Refractory Adult Secondary Hemophagocytic Lymphohistiocytosis
This completed clinical trial evaluated the efficacy and safety of combining an interferon-gamma monoclonal antibody with dexamethasone for …
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: Open-label Study of ELA026 in Participants With Secondary Hemophagocytic Lymphohistiocytosis (sHLH) [Phase 2, Phase 3]
An open-label Phase 2/3 trial evaluating ELA026 for secondary Hemophagocytic Lymphohistiocytosis (sHLH) is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: Treatment of Familiar Lymphohistiocytosis [Phase 1, Phase 2]
A completed Phase 1/2 clinical trial update evaluating a treatment for Hemophagocytic lymphohistiocytosis (HLH) conducted by Assistance Publ…
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: A Post-authorization Study to Describe the Safety and Efficacy of Emapalumab for the Treatment of pHLH in Treatment Experienced Chinese Patients [Phase 4]
Phase 4 post-authorization study evaluating the safety and efficacy of emapalumab in treatment-experienced Chinese patients with primary hem…
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CLINICAL_TRIALS trial_result · 2026-02-19Clinical Trial Update: Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE [Phase 3]
A Phase 3 clinical trial evaluated the efficacy, safety, tolerability, and pharmacokinetics/pharmacodynamics of emapalumab in children and a…
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CLINICAL_TRIALS trial_result · 2025-12-26Clinical Trial Update: Treatment of Non Severe Hemophagocytosis Lymphohistiocytosis With ITACITINIB [Phase 2]
A Phase 2 clinical trial evaluating ITACITINIB for adults with non-severe hemophagocytic lymphohistiocytosis has completed.
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Children and Adult Hemophagocytic Syndrome (HLHa)
Completed clinical trial update from Assistance Publique - Hôpitaux de Paris on hemophagocytic lymphohistiocytosis (HLH) in children and adu…
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CLINICAL_TRIALS trial_result · 2025-10-30Clinical Trial Update: Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion [NA]
Clinical trial update from Baylor College of Medicine reports results for haploidentical hematopoietic cell transplantation using TCR alpha/…
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CLINICAL_TRIALS trial_result · 2025-06-24Clinical Trial Update: A Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetic Characteristics, and Immunogenicity of Plonmarlimab in Subjects With Rheumatic and Immunological Disease-associated Haemophagocytic Lymphohistiocytosis (HLH) (Also Known as Macrophage Activation Syndrome (MAS)) [Phase 2]
A Phase 2 study evaluating the efficacy, safety, tolerability, pharmacokinetic characteristics, and immunogenicity of plonmarlimab in subjec…
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CLINICAL_TRIALS trial_result · 2024-10-01Clinical Trial Update: Emapalumab Efficacy in Children With Primary Hemophagocytic Lymphohistiocytosis
Clinical trial update on the efficacy of emapalumab in children with primary Hemophagocytic Lymphohistiocytosis.
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Evaluation of IFNγ and Inflammatory Mediators in Patients With Malignancy-Associated Hemophagocytic Lymphohistiocytosis
A completed clinical trial assessed interferon-gamma and other inflammatory mediators in patients with malignancy-associated hemophagocytic …
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Evaluation of IFNγ and Inflammatory Mediators in Patients With Hemophagocytic Lymphohistiocytosis
A completed clinical trial evaluated interferon-gamma and other inflammatory mediators in patients with hemophagocytic lymphohistiocytosis; …
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CLINICAL_TRIALS trial_result · 2024-04-11Clinical Trial Update: Zanubrutinib for HLH [Phase 3]
Phase 3 clinical trial update for zanubrutinib in hemophagocytic lymphohistiocytosis (HLH) has completed.
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CLINICAL_TRIALS trial_result · 2024-03-25Clinical Trial Update: Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases [Phase 1]
Phase 1 safety study of gene-modified donor T cell infusion after stem cell transplantation for non-malignant diseases has been terminated; …
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CLINICAL_TRIALS trial_result · 2024-03-12Clinical Trial Update: Study to Assess the Efficacy and Safety of Emapalumab in Primary Haemophagocytic Lymphohistiocytosis [Phase 3]
Phase 3 trial assessing efficacy and safety of emapalumab in primary hemophagocytic lymphohistiocytosis has completed with results posted in…
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CLINICAL_TRIALS trial_result · 2024-01-17Clinical Trial Update: Alemtuzumab or Tocilizumab in Combination With Etoposide and Dexamethasone for the Treatment of Adult Patients With Hemophagocytic Lymphohistiocytosis [Phase 2]
Phase 2 trial evaluating alemtuzumab or tocilizumab in combination with etoposide and dexamethasone for adults with hemophagocytic lymphohis…
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CLINICAL_TRIALS trial_result · 2023-10-06Clinical Trial Update: A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Emapalumab in Adult Patients With HLH [Phase 2, Phase 3]
Phase 2/3 trial evaluating emapalumab in adults with hemophagocytic lymphohistiocytosis was terminated; results posted.
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CLINICAL_TRIALS trial_result · 2023-09-14Clinical Trial Update: GTP Regimen in the Treatment of Refractory/Recurrent HLH [Phase 3]
Phase 3 trial update for the GTP regimen in difficult-to-treat hemophagocytic lymphohistiocytosis (HLH).
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CLINICAL_TRIALS trial_result · 2023-03-20Clinical Trial Update: L-DEP Regimen Combined With PD-1 Antibody as Induction Therapy for Epstein-Barr Virus-positive LA-HLH [Phase 3]
A Phase 3 trial is evaluating induction therapy with L-DEP regimen plus a PD-1 antibody for Epstein-Barr Virus-positive hemophagocytic lymph…
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CLINICAL_TRIALS trial_result · 2022-10-06Clinical Trial Update: Cytokine Guided Risk Stratification and Treatment in Pediatric Hemophagocytic Lymphohistiocytosis [Phase 4]
A Phase 4 clinical trial evaluating cytokine-guided risk stratification and treatment for pediatric hemophagocytic lymphohistiocytosis.
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CLINICAL_TRIALS trial_result · 2022-06-28Clinical Trial Update: A Study for Long-term Follow-up of Hemophagocytic Lymphohistiocytosis (HLH) Participants Who Received Treatment With Emapalumab (NI-0501), an Anti-interferon Gamma Monoclonal Antibody [Phase 2, Phase 3]
Long-term follow-up study of HLH patients treated with emapalumab (anti-IFNγ) across Phase 2/Phase 3 completed with posted results in 2022.
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CLINICAL_TRIALS trial_result · 2022-05-20Clinical Trial Update: Rituximab Monotherapy for EBV-HLH and CAEBV [Phase 3]
Phase 3 trial update on rituximab monotherapy for EBV-associated conditions, including Secondary Hemophagocytic Lymphohistiocytosis and Chro…
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CLINICAL_TRIALS trial_result · 2022-04-26Clinical Trial Update: L-DEP/DEP Regimen and PD-1 Antibody as a Treatment for Relapse/Refractory EBV-HLH [Phase 3]
A Phase 3 clinical trial evaluating L-DEP/DEP regimen with a PD-1 antibody for relapse/refractory EBV-HLH is not yet recruiting.
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CLINICAL_TRIALS trial_result · 2020-10-19Clinical Trial Update: Hybrid Immunotherapy for Hemophagocytic LymphoHistiocytosis [Phase 2]
A Phase 2 trial update on hybrid immunotherapy for Hemophagocytic Lymphohistiocytosis (HLH) has completed with results posted in 2020.
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CLINICAL_TRIALS trial_result · 2020-01-21Clinical Trial Update: T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts [Phase 2]
A Phase 2 clinical trial evaluating T cell depletion in recipients of HLA haploidentical related donor stem cell grafts for various hematolo…