Hemophagocytic Lymphohistiocytosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Prospective Cohort for Adult Hemophagocytosis
Prospective cohort study for adult hemophagocytic lymphohistiocytosis is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Retrospective Study of Immunotherapy Related Toxicities and Factors Impacting Outcomes in Children and Adults With Cancer
This clinical trial update reports a retrospective study evaluating immunotherapy-related toxicities and factors affecting outcomes in child…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Use Of A Response-Adapted Ruxolitinib-Containing Regimen For The Treatment Of Hemophagocytic Lymphohistiocytosis [Phase 1, Phase 2]
An update on a Phase 1/Phase 2 trial evaluating a response-adapted regimen that includes ruxolitinib for hemophagocytic lymphohistiocytosis.…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Comparison of Two Etoposide Initiation Strategies for Severe Hemophagocytic Lymphohistiocytosis [Phase 3]
Phase 3 clinical trial comparing two initiation strategies for etoposide in severe Hemophagocytic lymphohistiocytosis; the study is not yet …
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: Efficacy and Safety of Interferon-Gamma Monoclonal Antibody Combined With Dexamethasone in the Treatment of Refractory Adult Secondary Hemophagocytic Lymphohistiocytosis
This completed clinical trial evaluated the efficacy and safety of combining an interferon-gamma monoclonal antibody with dexamethasone for …
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating CD45RA-depleted stem cell addback to prevent viral or fungal infections following TCRab/CD19-deplet…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Combination of Mitoxantrone Liposome and Etoposide, Dexamethasone, Pegaspargase and Golidocitinib (MEPL-G) in the Treatment of NK/T-cell Lymphoma Associated Hemophagocytic Lymphohistiocytosis (NKTCL-HLH) [Phase 1, Phase 2]
An update on a Phase 1/Phase 2 trial of MEPL-G (mitoxantrone liposome, etoposide, dexamethasone, pegaspargase, and golodocitinib) for extran…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Ruxolitinib With De-Intensified HLH-94 for the Treatment of Hemophagocytic Lymphohistiocytosis (HLH) [Phase 2]
Phase 2 clinical trial evaluating ruxolitinib with a de-intensified HLH-94 regimen for Hemophagocytic Lymphohistiocytosis; currently recruit…
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: Open-label Study of ELA026 in Participants With Secondary Hemophagocytic Lymphohistiocytosis (sHLH) [Phase 2, Phase 3]
An open-label Phase 2/3 trial evaluating ELA026 for secondary Hemophagocytic Lymphohistiocytosis (sHLH) is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: Treatment of Familiar Lymphohistiocytosis [Phase 1, Phase 2]
A completed Phase 1/2 clinical trial update evaluating a treatment for Hemophagocytic lymphohistiocytosis (HLH) conducted by Assistance Publ…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE Study
This clinical trial update describes ongoing research to evaluate clinical, immunologic, and transcriptomic aspects of hemophagocytic lympho…
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FDA approval · 2026-03-17FDA Approved: GAMIFANT — Supplemental Application (Swedish Orphan Biovitrum AB (publ))
FDA approved a supplemental application for GAMIFANT (emapalumab-lzsg) submitted by Swedish Orphan Biovitrum AB (publ).
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: A Post-authorization Study to Describe the Safety and Efficacy of Emapalumab for the Treatment of pHLH in Treatment Experienced Chinese Patients [Phase 4]
Phase 4 post-authorization study evaluating the safety and efficacy of emapalumab in treatment-experienced Chinese patients with primary hem…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Tadekinig Alfa (IL-18BP) Rescue Therapy for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like Syndrome [EARLY_Phase 1]
Early-phase Phase 1 trial evaluating tadekinig alfa, an interleukin-18 binding protein, as rescue therapy for CAR T cell–related cytokine re…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: INTO-HLH: A Disease Registry for Patients With Hemophagocytic Lymphohistiocytosis (HLH)
A disease registry study for Hemophagocytic Lymphohistiocytosis (HLH) called INTO-HLH is currently recruiting.
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Immune Disorder HSCT Protocol [Phase 2]
Phase 2 clinical trial update on a hematopoietic stem cell transplant protocol for several inherited immune deficiency disorders; the study …
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CLINICAL_TRIALS trial_result · 2026-02-19Clinical Trial Update: Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE [Phase 3]
A Phase 3 clinical trial evaluated the efficacy, safety, tolerability, and pharmacokinetics/pharmacodynamics of emapalumab in children and a…
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CLINICAL_TRIALS other · 2026-01-27Clinical Trial Update: Golidocitinib Combined With Selinexor for CAEBVD [Phase 2, Phase 3]
A phase 2/phase 3 clinical trial evaluating golidocitinib in combination with selinexor for chronic active Epstein-Barr virus disease is cur…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: Describing Treatment Outcomes and Responses in Lymphoma-associated Hemophagocytic Lymphohistiocytosis
This clinical trial update indicates ongoing recruitment for a study documenting treatment outcomes and responses in lymphoma-associated hem…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Diagnosis of Lymphohistiocytic Hemophagocytosis in Intensive Care
A clinical trial at University Hospital Strasbourg is evaluating diagnostic approaches for hemophagocytic lymphohistiocytosis in intensive c…
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: Prospective Single-Arm Clinical Trial of GO Regimen for HLH. [Phase 2, Phase 3]
A prospective single-arm Phase 2/Phase 3 clinical trial evaluating the GO regimen for hemophagocytic lymphohistiocytosis is currently recrui…
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CLINICAL_TRIALS trial_result · 2025-12-26Clinical Trial Update: Treatment of Non Severe Hemophagocytosis Lymphohistiocytosis With ITACITINIB [Phase 2]
A Phase 2 clinical trial evaluating ITACITINIB for adults with non-severe hemophagocytic lymphohistiocytosis has completed.
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CLINICAL_TRIALS other · 2025-12-08Clinical Trial Update: Zanubrutinib Combined With Rituximab in the Treatment of Secondary HLH in B-cell Lymphoma [Phase 4]
A Phase 4 clinical trial is evaluating zanubrutinib in combination with rituximab for secondary hemophagocytic lymphohistiocytosis in patien…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: A Phase III Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of Plonmarlimab in Subjects With Relapsed/Refractory Rheumatic and Immunologic Disease-associated Haemophagocytic Lymphohistiocytosis (Also Known as Macrophage Activation Syndrome [MAS]) [Phase 3]
This clinical trial update describes a Phase III study evaluating the efficacy, safety, and tolerability of plonmarlimab in relapsed/refract…
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Children and Adult Hemophagocytic Syndrome (HLHa)
Completed clinical trial update from Assistance Publique - Hôpitaux de Paris on hemophagocytic lymphohistiocytosis (HLH) in children and adu…