Hemophagocytic Lymphohistiocytosis
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Prospective Cohort for Adult Hemophagocytosis
Prospective cohort study for adult hemophagocytic lymphohistiocytosis is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Retrospective Study of Immunotherapy Related Toxicities and Factors Impacting Outcomes in Children and Adults With Cancer
This clinical trial update reports a retrospective study evaluating immunotherapy-related toxicities and factors affecting outcomes in child…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Use Of A Response-Adapted Ruxolitinib-Containing Regimen For The Treatment Of Hemophagocytic Lymphohistiocytosis [Phase 1, Phase 2]
An update on a Phase 1/Phase 2 trial evaluating a response-adapted regimen that includes ruxolitinib for hemophagocytic lymphohistiocytosis.…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Comparison of Two Etoposide Initiation Strategies for Severe Hemophagocytic Lymphohistiocytosis [Phase 3]
Phase 3 clinical trial comparing two initiation strategies for etoposide in severe Hemophagocytic lymphohistiocytosis; the study is not yet …
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating CD45RA-depleted stem cell addback to prevent viral or fungal infections following TCRab/CD19-deplet…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Combination of Mitoxantrone Liposome and Etoposide, Dexamethasone, Pegaspargase and Golidocitinib (MEPL-G) in the Treatment of NK/T-cell Lymphoma Associated Hemophagocytic Lymphohistiocytosis (NKTCL-HLH) [Phase 1, Phase 2]
An update on a Phase 1/Phase 2 trial of MEPL-G (mitoxantrone liposome, etoposide, dexamethasone, pegaspargase, and golodocitinib) for extran…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Ruxolitinib With De-Intensified HLH-94 for the Treatment of Hemophagocytic Lymphohistiocytosis (HLH) [Phase 2]
Phase 2 clinical trial evaluating ruxolitinib with a de-intensified HLH-94 regimen for Hemophagocytic Lymphohistiocytosis; currently recruit…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE Study
This clinical trial update describes ongoing research to evaluate clinical, immunologic, and transcriptomic aspects of hemophagocytic lympho…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Tadekinig Alfa (IL-18BP) Rescue Therapy for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like Syndrome [EARLY_Phase 1]
Early-phase Phase 1 trial evaluating tadekinig alfa, an interleukin-18 binding protein, as rescue therapy for CAR T cell–related cytokine re…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: INTO-HLH: A Disease Registry for Patients With Hemophagocytic Lymphohistiocytosis (HLH)
A disease registry study for Hemophagocytic Lymphohistiocytosis (HLH) called INTO-HLH is currently recruiting.
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Immune Disorder HSCT Protocol [Phase 2]
Phase 2 clinical trial update on a hematopoietic stem cell transplant protocol for several inherited immune deficiency disorders; the study …
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: Describing Treatment Outcomes and Responses in Lymphoma-associated Hemophagocytic Lymphohistiocytosis
This clinical trial update indicates ongoing recruitment for a study documenting treatment outcomes and responses in lymphoma-associated hem…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Diagnosis of Lymphohistiocytic Hemophagocytosis in Intensive Care
A clinical trial at University Hospital Strasbourg is evaluating diagnostic approaches for hemophagocytic lymphohistiocytosis in intensive c…
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: Prospective Single-Arm Clinical Trial of GO Regimen for HLH. [Phase 2, Phase 3]
A prospective single-arm Phase 2/Phase 3 clinical trial evaluating the GO regimen for hemophagocytic lymphohistiocytosis is currently recrui…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: A Phase III Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of Plonmarlimab in Subjects With Relapsed/Refractory Rheumatic and Immunologic Disease-associated Haemophagocytic Lymphohistiocytosis (Also Known as Macrophage Activation Syndrome [MAS]) [Phase 3]
This clinical trial update describes a Phase III study evaluating the efficacy, safety, and tolerability of plonmarlimab in relapsed/refract…
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CLINICAL_TRIALS research · 2025-09-08Clinical Trial Update: Conception of a Diagnosis, Prognosis and Therapeutic Decision Tool for Patients With Autoimmunity and Inflammation
A recruiting clinical trial in France aims to develop a diagnosis, prognosis, and therapeutic decision-support tool for autoimmune and infla…
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation [Phase 1, Phase 2]
This document provides an update on a phase 1/2 clinical trial evaluating CD34+ stem cell selection for patients receiving allogeneic stem c…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Administration of Donor T Cells With the Caspase-9 Suicide Gene [Phase 1]
A Phase 1 trial evaluating donor T cells engineered with a caspase-9 suicide gene to enable controlled safety in hematologic diseases.
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CLINICAL_TRIALS research · 2025-05-13Clinical Trial Update: Prospective Validation of the OHI Index
A prospective trial to validate the OHI Index for HLH-related conditions, with recruitment ongoing at Meir Medical Center.
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CLINICAL_TRIALS research · 2025-04-30Clinical Trial Update: Dose-modified Emapalumab and Ruxolitinib (E-Ru) Regimens for Hemophagocytic Lymphohistiocytosis [Phase 2, Phase 3]
This clinical trial update outlines dose-modified regimens combining emapalumab and ruxolitinib (E-Ru) for hemophagocytic lymphohistiocytosi…
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CLINICAL_TRIALS research · 2025-03-28Clinical Trial Update: Gut Health in Children With Cancer
A clinical trial update indicates that a study on gut health in children with cancer is currently recruiting, enrolling conditions including…
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CLINICAL_TRIALS research · 2024-10-01Clinical Trial Update: Establishment of an Early Warning Screening System for Hemophagocytic Lymphohistiocytosis a Multi-center, Prospective Study
A multi-center prospective study to establish an early warning screening system for Hemophagocytic lymphohistiocytosis, currently recruiting…
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CLINICAL_TRIALS research · 2024-09-05Clinical Trial Update: Flow Cytometry for the Study of T-Cell Populations in Hemophagocytic Lymphohistiocytosis Associated With Lymphomas
A clinical trial investigating flow cytometry to study T-cell populations in lymphoma-associated hemophagocytic lymphohistiocytosis, current…
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CLINICAL_TRIALS research · 2024-08-05Clinical Trial Update: Modified DEP Regimens for the Treatment of Hemophagocytic Lymphohistiocytosis [Phase 4]
This clinical trial update reports on a Phase 4 study evaluating modified DEP regimens for the treatment of hemophagocytic lymphohistiocytos…
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CLINICAL_TRIALS research · 2024-07-11Clinical Trial Update: A Study on Efficacy and Safety of iNK Cells for CAEBV /EBV-HLH After Allo-HSCT [NA]
This ClinicalTrials.gov entry describes a study evaluating the efficacy and safety of iNK cells for chronic active Epstein-Barr virus infect…