Graft-versus-host Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Leflunomide in Combination With Steroids for the Treatment of Acute Graft-versus-Host Disease After Donor Stem Cell Transplant for Hematologic Malignancies [Phase 1]
A Phase 1 trial is evaluating leflunomide in combination with steroids for acute graft-versus-host disease after donor stem cell transplanta…
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning [Phase 2]
Phase 2 trial evaluating vedolizumab with post-transplant cyclophosphamide and tacrolimus to prevent graft-versus-host disease in patients u…
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CLINICAL_TRIALS research · 2025-06-26Clinical Trial Update: Effect of Stem Cell Infusion Time on aGVHD in Patients With Nonmalignant Hematologic Diseases [Phase 3]
A Phase 3 clinical trial is investigating whether the timing of stem cell infusion affects the development of acute graft-versus-host diseas…
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CLINICAL_TRIALS research · 2025-06-22Clinical Trial Update: A Clinical Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Belumosudil in Chinese Adolescents With cGVHD Who Have Had an Inadequate Response to Glucocorticoids or Other Systemic Therapies [Phase 4]
Phase 4 study evaluating pharmacokinetics, efficacy, and safety of Belumosudil in Chinese adolescents with chronic graft-versus-host disease…
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CLINICAL_TRIALS research · 2025-06-22Clinical Trial Update: A Randomized Phase II Study to Compare the Potential Long-Lasting Positive Effect of Decidual Stromal Cells to the Best Available Treatment in Graft Versus Host Disease [Phase 2]
A Phase II randomized trial is comparing decidual stromal cells to the best available treatment for graft-versus-host disease. The study is …
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CLINICAL_TRIALS trial_result · 2025-06-18Clinical Trial Update: Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia Major [Phase 4]
Phase 4 trial evaluating Basiliximab to prevent acute graft-versus-host disease after unrelated donor hematopoietic stem cell transplantatio…
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CLINICAL_TRIALS trial_result · 2025-06-17Clinical Trial Update: A Study of Itolizumab in Combination With Corticosteroids for the First-Line Treatment of Acute Graft Versus Host Disease (EQUATOR) [Phase 3]
A Phase 3 trial evaluating itolizumab in combination with corticosteroids for first-line acute graft-versus-host disease was terminated.
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CLINICAL_TRIALS research · 2025-06-10Clinical Trial Update: Autologous Serum Obtained by a Closed-Circuit Collection Device [Phase 2]
Phase 2 clinical trial evaluating autologous serum obtained by a closed-circuit collection device for several ocular surface diseases; recru…
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CLINICAL_TRIALS research · 2025-06-10Clinical Trial Update: Gecacitinib for cGVHD: Safety and Efficacy in Patients After ≥2 Lines of Prior Therapy [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the safety and efficacy of gecacitinib for chronic graft-versus-host disease in patients with at least…
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CLINICAL_TRIALS trial_result · 2025-06-05Clinical Trial Update: Infliximab Efficacy, TDM and Serum TNFα Levels in Pediatric HSCT Recipients With aGVHD: Prospective Observational Study
A completed prospective observational study in pediatric hematopoietic stem cell transplant recipients with acute graft-versus-host disease …
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CLINICAL_TRIALS trial_result · 2025-06-05Clinical Trial Update: Tacrolimus Blood Concentration and Transplant-related Outcomes in Pediatric HSCT Recipients
A completed pediatric hematopoietic stem cell transplant trial assessing how tacrolimus blood concentration relates to transplant-related ou…
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CLINICAL_TRIALS research · 2025-06-05Clinical Trial Update: Dapagliflozin in Allo-HCT for aGVHD [Phase 2]
A Phase 2 clinical trial is evaluating dapagliflozin for acute graft-versus-host disease after allogeneic stem cell transplantation, and the…
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CLINICAL_TRIALS trial_result · 2025-06-04Clinical Trial Update: Ruxolitinib With Calcineurin Inhibitor and Methotrexate vs. Calcineurin Inhibitor Plus Methotrexate and Mycophenolate Mofetil as Graft Versus Host Disease Prophylaxis for HLA-haploidentical Hematopoietic Stem Cell Transplantation [NA]
This completed clinical trial compares ruxolitinib-based graft-versus-host disease prophylaxis (with a calcineurin inhibitor and methotrexat…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: MTX and Steroid as First-line Therapy for aGVHD [Phase 3]
Phase 3 trial evaluating methotrexate plus steroids as first-line therapy for acute graft-versus-host disease has completed.
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Mini-dose MTX Plus Standard-dose Steroid for the Initial Treatment of Acute GVHD [Phase 3]
A Phase 3 trial evaluating mini-dose methotrexate in combination with standard-dose steroids as initial treatment for acute graft-versus-hos…
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CLINICAL_TRIALS research · 2025-05-30Clinical Trial Update: Emapalumab With Post-Transplant Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Graft-versus-Host Disease After Donor Reduced-Intensity Hematopoietic Cell Transplant [Phase 1]
Phase 1 trial evaluating emapalumab with post-transplant cyclophosphamide, tacrolimus and mycophenolate mofetil to prevent graft-versus-host…
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CLINICAL_TRIALS other · 2025-05-23Clinical Trial Update: A Study to Investigate the Comparative Effectiveness of Ibrutinib in Steroid Dependent/Refractory cGVHD Participants
A clinical trial evaluating the comparative effectiveness of ibrutinib in steroid-dependent/refractory chronic graft-versus-host disease has…
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CLINICAL_TRIALS research · 2025-05-20Clinical Trial Update: Axatilimab in Combination With Extracorporeal Photopheresis (ECP) in Chronic Graft-versus-Host Disease [Phase 2]
A Phase 2 clinical trial evaluating Axatilimab in combination with extracorporeal photopheresis for chronic graft-versus-host disease (cGVHD…
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CLINICAL_TRIALS research · 2025-05-11Clinical Trial Update: ATG Plus PTCy vs ATG for CGVHD Prophylaxis [Phase 2]
Phase 2 trial comparing ATG plus post-transplant cyclophosphamide versus ATG for prophylaxis of chronic graft-versus-host disease in patient…
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CLINICAL_TRIALS trial_result · 2025-05-06Clinical Trial Update: Treatment Safety and Efficacy of Pro-ocular™ 1% for Chronic Ocular Graft Following Allogeneic HSCT. [Phase 2]
A Phase 2 trial assessing the safety and efficacy of Pro-ocular 1% for chronic ocular graft-versus-host disease has completed and results ha…
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: Extended Treatment and Follow-up of Subjects Treated With Belumosudil in Study KD025-208 or Study KD025-213 [Phase 2]
A phase 2 update reports extended treatment and follow-up data for belumosudil in KD025-208 and KD025-213 for chronic graft-versus-host dise…
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CLINICAL_TRIALS research · 2025-05-02Clinical Trial Update: Pediatric GVHD Low Risk Steroid Taper Trial [Phase 2]
Phase 2 pediatric trial evaluating a low-risk steroid taper strategy for acute graft-versus-host disease in allogeneic bone marrow transplan…
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CLINICAL_TRIALS trial_result · 2025-04-30Clinical Trial Update: CXCL9 and EASIX for Prediction of Acute Graft Versus Host Disease
This ClinicalTrials.gov entry describes a study evaluating CXCL9 and EASIX as predictors for acute graft-versus-host disease, currently recr…
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CLINICAL_TRIALS trial_result · 2025-04-30Clinical Trial Update: Expressive Writing in GVHD [EARLY_Phase 1]
This clinical trial update reports that a Phase 1 early study examining expressive writing as an intervention for Graft Versus Host Disease …
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CLINICAL_TRIALS research · 2025-04-29Clinical Trial Update: A Study of iMSC for the Prevention of Acute Graft-versus-host Disease After Allogeneic Hematopoietic Stem Cell Transplantation [EARLY_Phase 1]
Early-phase clinical trial evaluating iMSC to prevent acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantati…