Graft-versus-host Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-06-12Clinical Trial Results: Topical Fibrinogen-Depleted Human Platelet Lysate in Patients With Dry Eye Secondary to Graft vs. Host Disease [Phase 1, Phase 2]
Phase 1/2 trial investigating topical fibrinogen-depleted human platelet lysate for dry eye associated with graft-versus-host disease; resul…
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: Phase III Study Comparing GVHD Prophylaxis With ATG-thymoglobulin to ATLG-grafalon in Elderly Patients With Acute Myeloid Leukemia or Myelodysplasic Syndrome and Receiving an Allogeneic Hematopoietic Stem Cell Transplantation With a 10/10 HLA Matched Unrelated Donor [Phase 3]
Phase III study comparing ATG-thymoglobulin vs ATLG-grafalon for GVHD prophylaxis in elderly AML/MDS patients undergoing matched unrelated d…
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CLINICAL_TRIALS trial_result · 2026-04-22Clinical Trial Update: The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft-versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant [Phase 2, Phase 3]
Phase 2/Phase 3 clinical trial update evaluating alpha-1 antitrypsin for the prevention of graft-versus-host disease in patients undergoing …
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: Belimumab for Prevention of Chronic Graft-versus-Host Disease Following Allogeneic Hematopoietic Cell Transplantation [Phase 1]
Phase 1 trial evaluating belimumab to prevent chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation has comp…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: Belumosudil and Rituximab for Primary Treatment of Chronic Graft-Versus-Host-Disease [Phase 2]
A Phase 2 clinical trial evaluating belumosudil combined with rituximab as primary treatment for chronic graft-versus-host disease is curren…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: A Study of Belumosudil in People at Risk of Developing Graft-Versus-Host Disease After a Stem Cell Transplant [Phase 2]
Phase 2 clinical trial evaluating belumosudil for people at risk of graft-versus-host disease after stem cell transplant is currently recrui…
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: CD40-L Blockade for Prevention of Acute Graft-Versus-Host Disease [Phase 1]
This clinical trial update reports completion of a Phase 1 study evaluating CD40-L blockade to prevent acute graft-versus-host disease.
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Evaluation of Allogenic Mesenchymal Stem Cell (MSC) Injection Therapy for Refractory Graft-versus-Host Disease (GVHD) Unresponsive to Conventional Treatments [Phase 2]
Phase 2 clinical trial evaluating donor-derived allogeneic mesenchymal stem cell injections for refractory graft-versus-host disease. The st…
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: Dietary Manipulation of the Microbiome-metabolomic Axis for Mitigating GVHD in Allo HCT Patients [Phase 2]
This clinical trial update reports the completion of a Phase 2 study evaluating dietary modification of the microbiome–metabolomic axis to m…
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: Ruxolitinib, Human Chorionic Gonadotropin (uhCG/EGF), and Dose De-escalated Corticosteroids [Phase 1, Phase 2]
A Phase 1/2 clinical trial investigating ruxolitinib, human chorionic gonadotropin, and dose-de-escalated corticosteroids for acute graft-ve…
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CLINICAL_TRIALS trial_result · 2026-03-23Clinical Trial Update: Evaluation of the Impact of Reduced Immunosuppression
A completed clinical trial evaluating the outcomes of reducing immunosuppression in patients with graft-versus-host disease.
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CLINICAL_TRIALS trial_result · 2026-03-17Clinical Trial Update: SYN-004 Safety and Tolerability in Allo-HCT Subjects [Phase 1, Phase 2]
Phase 1/Phase 2 trial evaluating safety and tolerability of SYN-004 in adults undergoing allogeneic hematopoietic stem cell transplantation,…
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CLINICAL_TRIALS trial_result · 2026-03-16Clinical Trial Update: CINC424A2X01B Rollover Protocol [Phase 4]
Phase 4 rollover protocol for CINC424A2X01B is active but not recruiting, spanning Primary Myelofibrosis, Polycythemia Vera, Graft-versus-ho…
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: De-escalated Cyclophosphamide (PTCy) and Ruxolitinib for Graft-versus-Host Disease (GVHD) Prophylaxis [Phase 2]
Phase 2 study exploring de-escalated post-transplant cyclophosphamide (PTCy) combined with ruxolitinib for GVHD prophylaxis; the trial is cu…
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: Tacrolimus Toothpaste for Management of Oral Chronic Graft vs. Host Disease (cGVHD) [Phase 1]
A Phase 1 clinical trial evaluating tacrolimus toothpaste for managing oral chronic graft-versus-host disease has completed.
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CLINICAL_TRIALS trial_result · 2026-03-05Clinical Trial Update: Complement and Graft-versus-host Disease [NA]
Clinical trial on the role of complement in graft-versus-host disease has completed in allogeneic transplant recipients.
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CLINICAL_TRIALS trial_result · 2026-03-03Clinical Trial Update: CD34+ Enriched Transplants to Treat Myelodysplastic Syndrome [Phase 2]
This Phase 2 trial of CD34+ enriched transplants to treat myelodysplastic syndromes is currently suspended.
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CLINICAL_TRIALS trial_result · 2026-02-25Clinical Trial Update: Upfront Ruxolitinib for Chronic Graft-vs-host Disease [Phase 1]
A Phase 1 clinical trial evaluating upfront ruxolitinib for chronic graft-versus-host disease has been terminated.
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CLINICAL_TRIALS trial_result · 2026-02-25Clinical Trial Update: Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant [Phase 2]
A Phase 2 clinical trial update describes acute Graft-versus-host disease suppression using costimulation blockade in non-malignant transpla…
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CLINICAL_TRIALS trial_result · 2026-02-24Clinical Trial Update: Evaluation of Umbilical Cord-Derived Wharton's Jelly Stem Cells for the Treatment of Acute Graft Versus Host Disease [Phase 1]
Phase 1 clinical trial evaluating umbilical cord-derived Wharton's jelly stem cells for the treatment of acute graft-versus-host disease has…
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CLINICAL_TRIALS trial_result · 2026-02-18Clinical Trial Update: Evaluation of Belumosudil Whole Tablets vs. Crushed Tablets Pharmacokinetics in Patients Suffering From Chronic GvHD
Clinical trial update describing a pharmacokinetics study comparing whole versus crushed Belumosudil tablets in patients with chronic graft-…
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CLINICAL_TRIALS trial_result · 2026-02-17Clinical Trial Update: Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease [Phase 2]
Belumosudil is being studied in a Phase 2 trial for pre-emptive treatment of chronic graft-versus-host disease; the study is currently recru…
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CLINICAL_TRIALS trial_result · 2026-02-11Clinical Trial Update: In Vitro Effect Study of Interleukin-2 Muteins on Regulatory T Cells of Patients With Different Autoimmune, Allo-immune or Inflammatory Diseases [NA]
A completed clinical trial update reporting an in vitro study of interleukin-2 muteins on regulatory T cells in patients with autoimmune, al…
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CLINICAL_TRIALS trial_result · 2026-02-10Clinical Trial Update: Study of the Safety and Efficacy of Ruxolitinib Cream for Non-Sclerotic Chronic Cutaneous Graft-Versus-Host Disease [Phase 2]
This update reports results from a Phase 2 trial evaluating the safety and efficacy of ruxolitinib cream for non-sclerotic cutaneous chronic…
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CLINICAL_TRIALS trial_result · 2026-02-10Clinical Trial Update: Sitagliptin for Prevention of aGVHD After Alternative Donor Transplation [Phase 3]
This entry reports a Phase 3 clinical trial evaluating sitagliptin to prevent acute graft-versus-host disease after allogeneic hematopoietic…