Graft-versus-host Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Ocular Complications From Cancer Therapy - Patient Registry and Biobank
This clinical trial update describes a patient registry and biobank investigating ocular complications from cancer therapy, including graft-…
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CLINICAL_TRIALS trial_result · 2026-03-05Clinical Trial Update: Complement and Graft-versus-host Disease [NA]
Clinical trial on the role of complement in graft-versus-host disease has completed in allogeneic transplant recipients.
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: Vitamin C With Steroids for Gastrointestinal GVHD [EARLY_Phase 1]
A Baylor College of Medicine–led early-phase trial (NCT07197749) is evaluating vitamin C with steroids for gastrointestinal graft-versus-hos…
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CLINICAL_TRIALS trial_result · 2026-03-03Clinical Trial Update: CD34+ Enriched Transplants to Treat Myelodysplastic Syndrome [Phase 2]
This Phase 2 trial of CD34+ enriched transplants to treat myelodysplastic syndromes is currently suspended.
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: A Study to Investigate Safety of Belumosudil in Participants Aged 12 Years and Above, With Chronic Graft-versus-host Disease (cGVHD) [Phase 4]
Phase 4 clinical trial to evaluate the safety of Belumosudil in participants aged 12 years and older with chronic graft-versus-host disease;…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease [NA]
The update indicates a multicenter trial evaluating multidisciplinary interventions for adults with chronic graft-versus-host disease that i…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Co-Transplant of an Unmodified Haplo-Identical Graft With Cord Blood [Phase 2]
Phase 2 clinical trial evaluating co-transplant of an unmodified haplo-identical graft with cord blood; the study targets acute graft-versus…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Efficacy and Safety of Gecacitinib Hydrochloride in Prophylaxis Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Myelofibrosis [NA]
A clinical trial evaluating gecacitinib hydrochloride for prophylaxis of acute graft-versus-host disease after allogeneic hematopoietic stem…
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CLINICAL_TRIALS trial_result · 2026-02-25Clinical Trial Update: Upfront Ruxolitinib for Chronic Graft-vs-host Disease [Phase 1]
A Phase 1 clinical trial evaluating upfront ruxolitinib for chronic graft-versus-host disease has been terminated.
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CLINICAL_TRIALS trial_result · 2026-02-25Clinical Trial Update: Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant [Phase 2]
A Phase 2 clinical trial update describes acute Graft-versus-host disease suppression using costimulation blockade in non-malignant transpla…
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CLINICAL_TRIALS trial_result · 2026-02-24Clinical Trial Update: Evaluation of Umbilical Cord-Derived Wharton's Jelly Stem Cells for the Treatment of Acute Graft Versus Host Disease [Phase 1]
Phase 1 clinical trial evaluating umbilical cord-derived Wharton's jelly stem cells for the treatment of acute graft-versus-host disease has…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: PTCY Plus uhCG/EGF for Graft Versus Host Disease Prophylaxis [Phase 1]
A Phase 1 clinical trial evaluating the combination of post-transplant cyclophosphamide (PTCY) with uhCG/EGF for prophylaxis of graft-versus…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Extended vs Short-term Abatacept Dosing for Graft Versus Host Disease Prophylaxis [Phase 2]
A Phase 2 clinical trial is evaluating whether extended dosing of abatacept is as effective as short-term dosing for preventing graft-versus…
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CLINICAL_TRIALS trial_result · 2026-02-18Clinical Trial Update: Evaluation of Belumosudil Whole Tablets vs. Crushed Tablets Pharmacokinetics in Patients Suffering From Chronic GvHD
Clinical trial update describing a pharmacokinetics study comparing whole versus crushed Belumosudil tablets in patients with chronic graft-…
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CLINICAL_TRIALS trial_result · 2026-02-17Clinical Trial Update: Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease [Phase 2]
Belumosudil is being studied in a Phase 2 trial for pre-emptive treatment of chronic graft-versus-host disease; the study is currently recru…
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CLINICAL_TRIALS withdrawal · 2026-02-12Clinical Trial Update: Safety and Efficacy of Oral Belumosudil in Black or African American, American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander Male and Female Participants Aged 12 Years and Above With Chronic Graft Versus Host Disease (cGVHD) After At Least 2 Prior Lines of Systemic Therapy [Phase 2]
A Phase 2 trial evaluating the safety and efficacy of oral belumosudil in chronic graft-versus-host disease in diverse participants has been…
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CLINICAL_TRIALS research · 2026-02-11Clinical Trial Update: BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP) [Phase 2]
A Phase 2 clinical trial BEBOP evaluating belumosudil for prevention and treatment of bronchiolitis obliterans syndrome and bronchiolitis ob…
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CLINICAL_TRIALS trial_result · 2026-02-11Clinical Trial Update: In Vitro Effect Study of Interleukin-2 Muteins on Regulatory T Cells of Patients With Different Autoimmune, Allo-immune or Inflammatory Diseases [NA]
A completed clinical trial update reporting an in vitro study of interleukin-2 muteins on regulatory T cells in patients with autoimmune, al…
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CLINICAL_TRIALS trial_result · 2026-02-10Clinical Trial Update: Study of the Safety and Efficacy of Ruxolitinib Cream for Non-Sclerotic Chronic Cutaneous Graft-Versus-Host Disease [Phase 2]
This update reports results from a Phase 2 trial evaluating the safety and efficacy of ruxolitinib cream for non-sclerotic cutaneous chronic…
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CLINICAL_TRIALS trial_result · 2026-02-10Clinical Trial Update: Sitagliptin for Prevention of aGVHD After Alternative Donor Transplation [Phase 3]
This entry reports a Phase 3 clinical trial evaluating sitagliptin to prevent acute graft-versus-host disease after allogeneic hematopoietic…
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia [Phase 1]
This entry reports a Phase 1 dose-escalation trial of mesenchymal stromal cells for medical xerostomia, including patients with graft-versus…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Trial of Regulatory T-cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease [Phase 1]
This clinical trial is evaluating regulatory T-cell therapy in combination with low-dose interleukin-2 for steroid-refractory chronic graft-…
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CLINICAL_TRIALS research · 2026-02-03Clinical Trial Update: A Ph1b/2 Study of Axatilimab Monotherapy in Chinese Participants With Recurrent or Refractory cGVHD [Phase 1, Phase 2]
An update on a Phase 1b/2 trial of axatilimab as monotherapy in Chinese participants with recurrent or refractory chronic graft-versus-host-…
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CLINICAL_TRIALS research · 2026-02-02Clinical Trial Update: A Clinical Study on the Efficacy and Safety of Ivarmacitinib in Preventing aGVHD After HLA-matched Transplantation [Phase 1, Phase 2]
A clinical trial update for a phase 1/2 study evaluating the efficacy and safety of Ivarmacitinib to prevent acute graft-versus-host disease…
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EMA approval · 2026-01-30New medicine to treat chronic graft-versus-host disease
The European Medicines Agency has approved Rezurock (belumosudil) for adults with chronic graft-versus-host disease after failure or intoler…