Graft-versus-host Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2017-02-09Clinical Trial Update: Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission [Phase 3]
Phase 3 trial evaluating tacrolimus and methotrexate with or without sirolimus to prevent graft-versus-host disease in young patients underg…
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CLINICAL_TRIALS trial_result · 2017-02-03Clinical Trial Update: Rapamycin for Prevention of Chronic Graft-Versus-Host Disease [Phase 1, Phase 2]
A Phase 1/2 trial evaluated rapamycin (sirolimus) for the prevention of chronic graft-versus-host disease; the study was terminated and resu…
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CLINICAL_TRIALS research · 2017-02-01Clinical Trial Update: Evaluation of the Diagnostic Value of PET (18F-FDG) in Chronic Graft Versus Host Disease (cGVH) [NA]
Clinical trial update evaluating the diagnostic value of PET imaging with 18F-FDG for chronic graft-versus-host disease.
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CLINICAL_TRIALS trial_result · 2017-02-01Clinical Trial Update: Combination of Alemtuzumab and Rituximab at Low-doses in Refractory Chronic Graft-Versus-Host Disease [NA]
A completed clinical trial evaluating low-dose alemtuzumab with rituximab for refractory chronic graft-versus-host disease, with results pos…
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CLINICAL_TRIALS trial_result · 2017-01-26Clinical Trial Update: Allogeneic Transplantation From Related Haploidentical Donors [Phase 2]
A Phase 2 clinical trial evaluating allogeneic transplantation from related haploidentical donors for blood cancers and leukemia has complet…
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CLINICAL_TRIALS trial_result · 2017-01-25Clinical Trial Update: Allogenic Bone Marrow Mesenchymal Stem Cells Infusion in Patients With Steroid-refractory GVHD [Phase 1, Phase 2]
Clinical trial update reporting completion of a Phase 1/2 study evaluating infusion of allogeneic bone marrow mesenchymal stem cells for ste…
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CLINICAL_TRIALS trial_result · 2017-01-23Clinical Trial Update: Methylprednisolone With or Without Daclizumab in Treating Patients With Acute Graft-Versus-Host Disease [Phase 3]
Phase 3 clinical trial comparing methylprednisolone with or without daclizumab for acute graft-versus-host disease has completed and reporte…
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CLINICAL_TRIALS trial_result · 2017-01-20Clinical Trial Update: Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant [NA]
This clinical trial evaluated lithium carbonate for treatment of acute intestinal graft-versus-host disease following a donor stem cell tran…
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CLINICAL_TRIALS trial_result · 2017-01-10Clinical Trial Update: Pilot Study: Patients With Chronic Active Graft Versus Host Disease That Have Failed or Not Tolerated Standard Therapy.
A completed pilot clinical trial evaluating treatment options for chronic active graft-versus-host disease in patients who failed or could n…
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CLINICAL_TRIALS trial_result · 2017-01-09Clinical Trial Update: Test Extracorporeal Photopheresis (ECP) Treatment Before/After Allogeneic Bone Marrow Transplant (BMT) or Peripheral Blood Stem Cell (PBSC) Transplant to Prevent Graft Versus Host Disease [EARLY_Phase 1]
An early-phase 1 trial evaluated Extracorporeal Photopheresis given before or after allogeneic bone marrow or peripheral blood stem cell tra…
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CLINICAL_TRIALS trial_result · 2016-12-22Clinical Trial Update: Histone Deacetylase Inhibitor LBH589 in Addition to Corticosteroids in Patients With Acute Graft Versus Host Disease (GVHD) [Phase 1, Phase 2]
Phase 1/2 study evaluating panobinostat (LBH589) in addition to corticosteroids for acute graft-versus-host disease. Results were posted in …
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CLINICAL_TRIALS trial_result · 2016-12-08Clinical Trial Update: Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder [Phase 3]
Phase 3 trial evaluating cyclosporine eye drops to prevent eye graft-versus-host disease in patients after donor stem cell transplant for he…
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CLINICAL_TRIALS withdrawal · 2016-11-21Clinical Trial Update: CliniMACS® CD34+ Reagent System for Expanded Access Use
This clinical trial update states that expanded-access use of the CliniMACS CD34+ Reagent System is no longer available.
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CLINICAL_TRIALS trial_result · 2016-11-18Clinical Trial Update: Multicenter Clinical Trial for the Evaluation of Mesenchymal Stem Cells From Adipose Tissue in Patients With Chronic Graft Versus Host Disease. [Phase 1, Phase 2]
A multicenter Phase 1/2 trial evaluated adipose-derived mesenchymal stem cells for chronic graft-versus-host disease and is reported as comp…
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CLINICAL_TRIALS trial_result · 2016-10-21Clinical Trial Update: Montelukast to Treat Bronchiolitis Obliterans [Phase 2]
A Phase 2 trial of montelukast for bronchiolitis obliterans and chronic graft-versus-host disease has completed, with results posted in 2016…
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CLINICAL_TRIALS trial_result · 2016-10-10Clinical Trial Update: Safety and Efficacy Study of R932348 Ophthalmic Solution in Chronic Ocular Graft Versus Host Disease Patients(DROPS-2) [Phase 2]
Phase 2 safety and efficacy results for the ophthalmic solution R932348 in patients with chronic ocular graft-versus-host disease (DROPS-2) …
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CLINICAL_TRIALS trial_result · 2016-10-07Clinical Trial Update: Immune Mediated Disorders After Allogeneic Hematopoietic Cell Transplantation
A completed clinical trial update from Fred Hutchinson Cancer Center reports on immune-mediated disorders after allogeneic hematopoietic cel…
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CLINICAL_TRIALS trial_result · 2016-09-13Clinical Trial Update: A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients [Phase 2]
Phase 2 randomized, double-masked trial evaluating autologous serum eye drops for severe ocular chronic graft-versus-host disease in HSCT pa…
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CLINICAL_TRIALS trial_result · 2016-08-01Clinical Trial Update: Valproic Acid With Methylprenisonlone for the Treatment of Acute GVHD [Phase 2]
A Phase 2 clinical trial is evaluating the combination of valproic acid and methylprednisolone for treatment of acute graft-versus-host dise…
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EMA withdrawal · 2016-07-22EMA Application withdrawn: Begedina (begelomab) — Adienne S.r.l. S.U.
EMA withdrew the application for Begedina (begelomab) by Adienne S.r.l. S.U. for graft-versus-host disease/Hematopoietic Stem Cell Transplan…
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CLINICAL_TRIALS research · 2016-07-12Clinical Trial Update: Graft-versus-host Disease Associated Myelosuppression
This clinical trial update concerns graft-versus-host disease-associated myelosuppression, with related conditions including abnormal hemato…
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CLINICAL_TRIALS trial_result · 2016-06-27Clinical Trial Update: Fludarabine, Cyclophosphamide, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing a Donor Umbilical Cord Blood Transplant for Hematologic Cancer [NA]
This terminated clinical trial evaluated a conditioning regimen of fludarabine, cyclophosphamide, and total-body irradiation followed by cyc…
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CLINICAL_TRIALS trial_result · 2016-06-23Clinical Trial Update: Alemtuzumab and Cyclosporine for the Prevention of Graft vs Host Disease After Stem Cell Transplants [Phase 2]
Phase 2 trial evaluating alemtuzumab in combination with cyclosporine for preventing graft-versus-host disease after stem cell transplantati…
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CLINICAL_TRIALS trial_result · 2016-06-21Clinical Trial Update: Pharmacokinetics-based Mycophenolate Mofetil Dosing for GVHD Prevention [Phase 2]
Phase 2 trial evaluating pharmacokinetics-based dosing of mycophenolate mofetil to prevent graft-versus-host disease in allogeneic hematopoi…
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CLINICAL_TRIALS trial_result · 2016-06-15Clinical Trial Update: Imatinib and Rituximab in Treating Cutaneous Sclerosis in Patients With Chronic Graft-Versus-Host Disease [Phase 2]
A Phase 2 trial evaluating the combination of imatinib and rituximab for cutaneous sclerosis in chronic graft-versus-host disease has comple…