Falciparum Malaria
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Phase 2A Study of a Novel Antimalarial Pyrrolidinamide in Adult Patients With Uncomplicated P. Falciparum Malaria [Phase 2]
A Phase 2A study is evaluating a novel antimalarial pyrrolidinamide in adults with uncomplicated falciparum malaria. The trial is not yet re…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Safety, Tolerability and Efficacy Against Controlled Human Malaria Infection of PfSPZ-LARC2 Vaccine in Malaria-naïve Adults [Phase 1]
Phase 1 study to evaluate safety, tolerability, and efficacy of the PfSPZ-LARC2 malaria vaccine against controlled human malaria infection i…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Phase 1 Study to Assess an Escalating Dose, Multi-prime Vaccination Schedule of R21/Matrix-M™ [Phase 1]
Phase 1 study of escalating-dose, multi-prime R21/Matrix-M malaria vaccine is currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: A Study to Assess the Experimental Malaria Vaccines RH5.2-VLP and R21 [Phase 1]
Phase 1 clinical trial update assessing two experimental malaria vaccines, RH5.2-VLP and R21, for Falciparum malaria; the study is currently…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 With Matrix-M in Combination With R21/Matrix-M [Phase 2]
Phase 2 study evaluating malaria vaccines R78C and RH5.1 with the Matrix-M adjuvant, in combination with R21/Matrix-M, is currently active b…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 Combined With R21/Matrix-M (a "Multi-stage" Malaria Vaccine) [Phase 1]
Phase 1 clinical trial update describing a study of three malaria vaccine candidates (R78C, RH5.1, and the multi-stage R21/Matrix-M) from th…
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CLINICAL_TRIALS research · 2026-01-29Clinical Trial Update: CHILD (Child Health and Infection With Low Density) Malaria [NA]
This update states that the CHILD malaria trial sponsored by the University of California, San Francisco has completed.
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Perennial Malaria Chemoprevention in the Malaria Vaccine Era [Phase 4]
A Phase 4 clinical trial update evaluating perennial malaria chemoprevention in the malaria vaccine era. The study is currently not yet recr…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: MDA and Targeted Control Against Plasmodium Carriage in the Sahel [NA]
A clinical trial in the Sahel is evaluating targeted control against Plasmodium carriage in malaria, with the study currently active but not…
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: Clinical Evaluation of Long-term Sequelae in Patients With Severe Plasmodium Falciparum Malaria [NA]
A clinical trial evaluating long-term sequelae in patients with severe falciparum malaria has completed.
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: An Observational Study to Assess Effectiveness and Safety of The R21/Matrix-M Malaria Vaccine
An observational study is being conducted to assess the effectiveness and safety of the R21/Matrix-M malaria vaccine, and the study is curre…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: IGHID 12334 - After the Flood: Optimal Strategies to Prevent Malaria Epidemics Caused by Severe Flooding [NA]
An update on the IGHID 12334 trial evaluating strategies to prevent malaria epidemics after severe flooding; the study is currently active b…
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of LAI MMV055 Alone and in Combination With MMV371 in Healthy Participants [Phase 1]
Phase 1 single ascending dose study in healthy participants to assess safety, tolerability, and pharmacokinetics of long-acting injectable M…
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CLINICAL_TRIALS trial_result · 2025-07-04Clinical Trial Update: Understanding and Maximizing the Community Impact of Antimalarial Treatment (INDIE-SMC) [NA]
The INDIE-SMC trial led by the London School of Hygiene and Tropical Medicine has completed, investigating how antimalarial treatment affect…
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria [Phase 1]
Phase 1 study evaluating safety, tolerability, and pharmacokinetics of Pyronaridine in healthy adult participants experimentally infected wi…
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CLINICAL_TRIALS trial_result · 2025-04-15Clinical Trial Update: Private Medicine Retailer-based Trial of Malaria Tests and Conditional Treatment Subsidies Among Patients With Fever [Phase 4]
Phase 4 clinical trial evaluating malaria testing and conditional treatment subsidies among fever patients conducted through private medicin…
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CLINICAL_TRIALS trial_result · 2025-03-05Clinical Trial Update: Safety and Efficacy of R0.6C Vaccine [Phase 1]
A Phase 1 trial from Radboud University Medical Center evaluated the safety and preliminary efficacy of the R0.6C malaria vaccine; the study…
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CLINICAL_TRIALS trial_result · 2025-02-20Clinical Trial Update: A Study to Determine if New Types of Malaria Vaccines Are Safe, Effective and Lead to Immunity in Kenyan Adults [Phase 2]
A Phase 2 malaria vaccine trial conducted in Kenyan adults has been terminated.
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CLINICAL_TRIALS research · 2024-12-27Clinical Trial Update: Durability of Protection After Single Immunisation With GA2 Sporozoites (CoGA-Rechallenge) [Phase 1]
Phase 1 clinical trial update assessing how durable protection is after a single immunisation with GA2 sporozoites (CoGA-Rechallenge) for fa…
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CLINICAL_TRIALS trial_result · 2024-11-20Clinical Trial Update: Effectiveness and Safety of Intermittent Preventive Treatment for Malaria Using Either Dihydroartemisinin-piperaquine or Artesunate-amodiaquine in Reducing Malaria Related Morbidities and Improving Cognitive Ability in School-aged Children in Tanzania [Phase 3]
A Phase 3 trial in Tanzanian school-aged children assessed the effectiveness and safety of intermittent preventive treatment for malaria usi…
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CLINICAL_TRIALS research · 2024-10-04Clinical Trial Update: A Study to Compare Two Dosing Regimens for a New Malaria Vaccine [Phase 1]
Phase 1 study comparing two dosing regimens for a new malaria vaccine to assess safety and preliminary immunogenicity.
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CLINICAL_TRIALS trial_result · 2024-09-20Clinical Trial Update: Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Extension Study [Phase 3]
Phase 3 extension study evaluating seasonal malaria vaccination RTS,S/AS01 with seasonal malaria chemoprevention SP/AQ in children has compl…
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CLINICAL_TRIALS trial_result · 2024-08-28Clinical Trial Update: Performance of an Ultrasensible Malaria Rapid Diagnostic Test Among Pregnant Women in Burkina Faso
This trial update reports on the performance of an ultrasensitive malaria rapid diagnostic test among pregnant women in Burkina Faso, using …
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CLINICAL_TRIALS research · 2024-08-26Clinical Trial Update: Malaria Molecular Surveillance in Mozambique (Phase 2)
Phase 2 malaria molecular surveillance trial in Mozambique is currently recruiting.
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CLINICAL_TRIALS research · 2024-07-29Clinical Trial Update: Host Immune Dynamics Following Seasonal Malaria Chemoprevention in African Children
This document provides an update on a clinical trial examining how seasonal malaria chemoprevention affects host immune responses in African…