Falciparum Malaria
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Phase 2A Study of a Novel Antimalarial Pyrrolidinamide in Adult Patients With Uncomplicated P. Falciparum Malaria [Phase 2]
A Phase 2A study is evaluating a novel antimalarial pyrrolidinamide in adults with uncomplicated falciparum malaria. The trial is not yet re…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Safety, Tolerability and Efficacy Against Controlled Human Malaria Infection of PfSPZ-LARC2 Vaccine in Malaria-naïve Adults [Phase 1]
Phase 1 study to evaluate safety, tolerability, and efficacy of the PfSPZ-LARC2 malaria vaccine against controlled human malaria infection i…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Phase 1 Study to Assess an Escalating Dose, Multi-prime Vaccination Schedule of R21/Matrix-M™ [Phase 1]
Phase 1 study of escalating-dose, multi-prime R21/Matrix-M malaria vaccine is currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: A Study to Assess the Experimental Malaria Vaccines RH5.2-VLP and R21 [Phase 1]
Phase 1 clinical trial update assessing two experimental malaria vaccines, RH5.2-VLP and R21, for Falciparum malaria; the study is currently…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 With Matrix-M in Combination With R21/Matrix-M [Phase 2]
Phase 2 study evaluating malaria vaccines R78C and RH5.1 with the Matrix-M adjuvant, in combination with R21/Matrix-M, is currently active b…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 Combined With R21/Matrix-M (a "Multi-stage" Malaria Vaccine) [Phase 1]
Phase 1 clinical trial update describing a study of three malaria vaccine candidates (R78C, RH5.1, and the multi-stage R21/Matrix-M) from th…
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CLINICAL_TRIALS research · 2026-01-29Clinical Trial Update: CHILD (Child Health and Infection With Low Density) Malaria [NA]
This update states that the CHILD malaria trial sponsored by the University of California, San Francisco has completed.
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Perennial Malaria Chemoprevention in the Malaria Vaccine Era [Phase 4]
A Phase 4 clinical trial update evaluating perennial malaria chemoprevention in the malaria vaccine era. The study is currently not yet recr…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: MDA and Targeted Control Against Plasmodium Carriage in the Sahel [NA]
A clinical trial in the Sahel is evaluating targeted control against Plasmodium carriage in malaria, with the study currently active but not…
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: An Observational Study to Assess Effectiveness and Safety of The R21/Matrix-M Malaria Vaccine
An observational study is being conducted to assess the effectiveness and safety of the R21/Matrix-M malaria vaccine, and the study is curre…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: IGHID 12334 - After the Flood: Optimal Strategies to Prevent Malaria Epidemics Caused by Severe Flooding [NA]
An update on the IGHID 12334 trial evaluating strategies to prevent malaria epidemics after severe flooding; the study is currently active b…
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of LAI MMV055 Alone and in Combination With MMV371 in Healthy Participants [Phase 1]
Phase 1 single ascending dose study in healthy participants to assess safety, tolerability, and pharmacokinetics of long-acting injectable M…
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CLINICAL_TRIALS research · 2024-12-27Clinical Trial Update: Durability of Protection After Single Immunisation With GA2 Sporozoites (CoGA-Rechallenge) [Phase 1]
Phase 1 clinical trial update assessing how durable protection is after a single immunisation with GA2 sporozoites (CoGA-Rechallenge) for fa…
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CLINICAL_TRIALS research · 2024-10-04Clinical Trial Update: A Study to Compare Two Dosing Regimens for a New Malaria Vaccine [Phase 1]
Phase 1 study comparing two dosing regimens for a new malaria vaccine to assess safety and preliminary immunogenicity.
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CLINICAL_TRIALS research · 2024-08-26Clinical Trial Update: Malaria Molecular Surveillance in Mozambique (Phase 2)
Phase 2 malaria molecular surveillance trial in Mozambique is currently recruiting.
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CLINICAL_TRIALS research · 2024-07-29Clinical Trial Update: Host Immune Dynamics Following Seasonal Malaria Chemoprevention in African Children
This document provides an update on a clinical trial examining how seasonal malaria chemoprevention affects host immune responses in African…
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CLINICAL_TRIALS research · 2018-04-27Clinical Trial Update: Evaluation of the Performance of a hsRDT Versus cRDT in Reactive Case Detection of Malaria Infections [NA]
This clinical trial compares the performance of a highly sensitive rapid diagnostic test (hsRDT) to a conventional rapid diagnostic test (cR…
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CLINICAL_TRIALS research · 2015-01-22Clinical Trial Update: Evaluation of Volume Status, Haemodynamics and Microcirculatory Flow in Adult Patients With Severe Falciparum Malaria
A University of Oxford-sponsored clinical trial evaluating volume status, haemodynamics, and microcirculatory flow in adults with severe fal…
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CLINICAL_TRIALS research · 2007-08-16Clinical Trial Update: Study to Investigate the Induction of an Protective Immune Response to Malaria [NA]
The clinical trial investigating induction of a protective immune response to falciparum malaria has completed.