Falciparum Malaria
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: Clinical Evaluation of Long-term Sequelae in Patients With Severe Plasmodium Falciparum Malaria [NA]
A clinical trial evaluating long-term sequelae in patients with severe falciparum malaria has completed.
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CLINICAL_TRIALS trial_result · 2025-07-04Clinical Trial Update: Understanding and Maximizing the Community Impact of Antimalarial Treatment (INDIE-SMC) [NA]
The INDIE-SMC trial led by the London School of Hygiene and Tropical Medicine has completed, investigating how antimalarial treatment affect…
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria [Phase 1]
Phase 1 study evaluating safety, tolerability, and pharmacokinetics of Pyronaridine in healthy adult participants experimentally infected wi…
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CLINICAL_TRIALS trial_result · 2025-04-15Clinical Trial Update: Private Medicine Retailer-based Trial of Malaria Tests and Conditional Treatment Subsidies Among Patients With Fever [Phase 4]
Phase 4 clinical trial evaluating malaria testing and conditional treatment subsidies among fever patients conducted through private medicin…
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CLINICAL_TRIALS trial_result · 2025-03-05Clinical Trial Update: Safety and Efficacy of R0.6C Vaccine [Phase 1]
A Phase 1 trial from Radboud University Medical Center evaluated the safety and preliminary efficacy of the R0.6C malaria vaccine; the study…
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CLINICAL_TRIALS trial_result · 2025-02-20Clinical Trial Update: A Study to Determine if New Types of Malaria Vaccines Are Safe, Effective and Lead to Immunity in Kenyan Adults [Phase 2]
A Phase 2 malaria vaccine trial conducted in Kenyan adults has been terminated.
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CLINICAL_TRIALS trial_result · 2024-11-20Clinical Trial Update: Effectiveness and Safety of Intermittent Preventive Treatment for Malaria Using Either Dihydroartemisinin-piperaquine or Artesunate-amodiaquine in Reducing Malaria Related Morbidities and Improving Cognitive Ability in School-aged Children in Tanzania [Phase 3]
A Phase 3 trial in Tanzanian school-aged children assessed the effectiveness and safety of intermittent preventive treatment for malaria usi…
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CLINICAL_TRIALS trial_result · 2024-09-20Clinical Trial Update: Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Extension Study [Phase 3]
Phase 3 extension study evaluating seasonal malaria vaccination RTS,S/AS01 with seasonal malaria chemoprevention SP/AQ in children has compl…
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CLINICAL_TRIALS trial_result · 2024-08-28Clinical Trial Update: Performance of an Ultrasensible Malaria Rapid Diagnostic Test Among Pregnant Women in Burkina Faso
This trial update reports on the performance of an ultrasensitive malaria rapid diagnostic test among pregnant women in Burkina Faso, using …
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CLINICAL_TRIALS trial_result · 2024-05-21Clinical Trial Update: The Impact RTS,S/AS01 Vaccine in School Aged Children RTS,S/AS01 Malaria Vaccine in School Aged Children [Phase 4]
Clinical trial update for the RTS,S/AS01 malaria vaccine in school-aged children; a Phase 4 study currently not yet recruiting.
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CLINICAL_TRIALS trial_result · 2024-03-29Clinical Trial Update: Seasonal Malaria Chemoprevention Rapid Assessment Study Mozambique [Phase 4]
Phase 4 trial update on seasonal malaria chemoprevention in Mozambique under Malaria Consortium.
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CLINICAL_TRIALS trial_result · 2023-11-21Clinical Trial Update: Reducing the Risk of P. Vivax After Falciparum Infections in Co-endemic Areas [Phase 4]
Phase 4 clinical trial evaluating strategies to reduce risk of Plasmodium vivax after Plasmodium falciparum infections in co-endemic areas, …
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CLINICAL_TRIALS trial_result · 2023-08-03Clinical Trial Update: A Study to Determine if a New Malaria Vaccine is Safe and Induces Immunity Among Kenyan Adults, Young Children and Infants [Phase 1, Phase 2]
A multicenter early-phase trial evaluating safety and immunogenicity of a new malaria vaccine in Kenyan adults, children, and infants has co…
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CLINICAL_TRIALS trial_result · 2023-03-07Clinical Trial Update: Seasonal Malaria Chemoprevention With Dihydroartemisin Piperaquin vs. Sulfadoxine-pyrimethamin+Amodiaquin [Phase 3]
Phase 3 trial update comparing dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine+amodiaquine for seasonal malaria chemoprevent…
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CLINICAL_TRIALS trial_result · 2023-02-23Clinical Trial Update: TES of Artemether-lumefantrine for Pf and Chloroquine for Pv in the Philippines From 2013-2014
A completed clinical trial update investigating artemether-lumefantrine for Plasmodium falciparum and chloroquine for Plasmodium vivax malar…
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CLINICAL_TRIALS trial_result · 2022-02-24Clinical Trial Update: Adjunctive Ivermectin Mass Drug Administration for Malaria Control [Phase 3]
Phase 3 clinical trial update on adjunctive ivermectin MDA for malaria control and related neglected tropical diseases.
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CLINICAL_TRIALS trial_result · 2022-01-18Clinical Trial Update: Gametocytocidal and Transmission-blocking Efficacy of PQ in Combination With AL and TQ in Combination With SPAQ in Mali [Phase 2]
Phase 2 clinical trial evaluating gametocytocidal and transmission-blocking efficacy of PQ with AL and TQ with SPAQ in malaria patients in M…
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CLINICAL_TRIALS trial_result · 2021-09-17Clinical Trial Update: Pyronaridine - Artesunate (3:1) Versus Mefloquine Plus Artesunate in Plasmodium Falciparum Malaria Patients [Phase 3]
Phase 3 trial comparing pyronaridine-artesunate (3:1) to mefloquine-artesunate in falciparum malaria has completed with results posted.
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CLINICAL_TRIALS trial_result · 2021-09-05Clinical Trial Update: Study in Blood Stage Malaria Infection After DVI of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites [Phase 1]
Phase 1 clinical trial investigating blood-stage malaria infection after direct venous inoculation of cryopreserved Plasmodium falciparum NF…
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CLINICAL_TRIALS trial_result · 2021-04-02Clinical Trial Update: Efficacy and Safety of Artesunate-amodiaquine and Artemether-lumefantrine for the Treatment of Malaria in Cameroon [Phase 4]
A Phase 4 trial update assessing efficacy and safety of artesunate-amodiaquine and artemether-lumefantrine for falciparum malaria in Cameroo…
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CLINICAL_TRIALS trial_result · 2021-04-02Clinical Trial Update: Effectiveness and Safety of Artesunate-Amodiaquine and Artemether-Lumefantrine for the Treatment of Malaria in Yaounde [Phase 4]
Phase 4 trial evaluating effectiveness and safety of artesunate-amodiaquine and artemether-lumefantrine for treating malaria in Yaounde, com…
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CLINICAL_TRIALS trial_result · 2020-06-09Clinical Trial Update: MMV390048 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Participants [Phase 1]
Phase 1 trial evaluating MMV390048 for early blood-stage infection of Falciparum malaria in healthy participants; study terminated with resu…
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CLINICAL_TRIALS trial_result · 2020-03-31Clinical Trial Update: Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2 [NA]
A completed clinical trial evaluating transmission-blocking interventions using a controlled human malaria infection model in malaria falcip…
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CLINICAL_TRIALS trial_result · 2020-03-25Clinical Trial Update: Methylene Blue Against Falciparum Malaria in Burkina Faso [Phase 2]
Phase 2 trial evaluating methylene blue for falciparum malaria completed in Burkina Faso with results posted.
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CLINICAL_TRIALS trial_result · 2018-05-09Clinical Trial Update: A Study by the Tracking Resistance to Artemisinin Collaboration (TRAC) [Phase 2, Phase 3]
This update notes the completion of Phase 2 and Phase 3 trials conducted by the TRAC collaboration on falciparum malaria.