Esophageal Squamous Cell Carcinoma

• CLINICAL_TRIALS trial_result · 2026-03-27
  Clinical Trial Update: A Study of Lomvastomig (RO7121661) and Tobemstomig (RO7247669) Compared With Nivolumab in Participants With Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus [Phase 2]

  Phase 2 trial comparing Roche investigational agents Lomvastomig and Tobemstomig with nivolumab in advanced or metastatic esophageal squamou…

• CLINICAL_TRIALS research · 2026-03-27
  Clinical Trial Update: Clinical Study on the Efficacy and Safety of Iparomlimab and Tuvonralimab Injection Combined With Nab-Paclitaxel in Neoadjuvant Therapy for Locally Advanced Resectable Esophageal Squamous Cell Carcinoma [Phase 2]

  Phase 2 trial evaluating the combination of Iparomlimab and Tuvonralimab with nab-paclitaxel as neoadjuvant therapy for locally advanced res…

• CLINICAL_TRIALS research · 2026-03-24
  Clinical Trial Update: Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors [Phase 2]

  A Phase 2 clinical trial evaluating Volrustomig as monotherapy or in combination with anti-cancer agents across multiple advanced/metastatic…

• CLINICAL_TRIALS research · 2026-03-24
  Clinical Trial Update: Neoadjuvant Therapy With Iparomlimab and Tuvonralimab, Lenvatinib and Chemotherapy in Resectable ESCC [Phase 2]

  Phase 2 neoadjuvant trial of iparomlimab and tuvonralimab with lenvatinib and chemotherapy for resectable esophageal squamous cell carcinoma…

• CLINICAL_TRIALS trial_result · 2026-03-23
  Clinical Trial Update: Development and Multicenter Validation of a Novel Bio-Anatomical Staging System for Predicting Survival and Tailoring Adjuvant Therapy in ESCC After Neoadjuvant Chemoimmunotherapy.

  A completed multicenter study validates a novel bio-anatomical staging system to predict survival and tailor adjuvant therapy for esophageal…

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• CLINICAL_TRIALS research · 2026-03-23
  Clinical Trial Update: A Phase 1/1b of RNDO-564 Single Agent or in Combination With Pembrolizumab in Bladder Cancer and Other Solid Tumors Associated With Nectin-4 [Phase 1]

  Phase 1/1b trial evaluating RNDO-564 as a single agent or in combination with pembrolizumab in bladder cancer and nectin-4–associated solid …

• CLINICAL_TRIALS research · 2026-03-23
  Clinical Trial Update: A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations [Phase 1, Phase 2]

  Phase 1/2 trial of TER-2013 in solid tumors harboring AKT/PI3K/PTEN alterations is currently recruiting to assess safety and preliminary eff…

• CLINICAL_TRIALS research · 2026-03-20
  Clinical Trial Update: KC1036 in Combination With PD-1 Antibody and Platinum-based Chemotherapy for First-line Advanced Esophageal Cancer [Phase 2]

  Phase 2 clinical trial evaluating KC1036 in combination with a PD-1 antibody and platinum-based chemotherapy as first-line treatment for adv…

• CLINICAL_TRIALS research · 2026-03-20
  Clinical Trial Update: A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B) [Phase 1, Phase 2]

  A Phase 1/Phase 2 trial in advanced esophageal squamous cell carcinoma is evaluating investigational agents with or without pembrolizumab in…

• CLINICAL_TRIALS research · 2026-03-19
  Clinical Trial Update: Tumor Microenvironment Changes After Neoadjuvant Chemo-Immunotherapy in Esophageal Squamous Cell Carcinoma

  This clinical trial update describes a neoadjuvant chemo-immunotherapy approach and investigation of tumor microenvironment changes in esoph…

• CLINICAL_TRIALS research · 2026-03-18
  Clinical Trial Update: Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumors [Phase 1, Phase 2]

  Roche is conducting a dose-escalation Phase 1/2 trial of a PD-1/LAG-3 bispecific antibody in patients with advanced or metastatic solid tumo…

• CLINICAL_TRIALS withdrawal · 2026-03-18
  Clinical Trial Update: Study of the Interest of Pursuing or Not the Chemotherapy for Patients With Metastatic Esophageal Cancer [Phase 2]

  A Phase 2 trial evaluating whether to pursue chemotherapy for metastatic esophageal squamous cell carcinoma was terminated.

• CLINICAL_TRIALS trial_result · 2026-03-13
  Clinical Trial Update: Study of MRI Guided Personal Chemoradiotherapy and Immunotherapy for Limited Advanced Esophageal Squamous Caicinoma. [Phase 2]

  Clinical trial update for a Phase 2 study of MRI-guided personalized chemoradiotherapy plus immunotherapy for limited advanced unresectable …

• CLINICAL_TRIALS research · 2026-03-11
  Clinical Trial Update: Efficacy and Safety of Neo-CRT Plus Serplulimab, Nimotuzumab in Patients With Locally Advanced Resectable ESCC [Phase 2]

  Phase 2 trial assessing the efficacy and safety of Neo-CRT plus Serplulimab and Nimotuzumab in locally advanced resectable esophageal squamo…

• CLINICAL_TRIALS research · 2026-03-09
  Clinical Trial Update: A Phase II Clinical Study of LBL-024 Combination Therapy in Patients With Advanced Solid Tumour[Substudy 03(ESCC)] [Phase 2]

  Phase II study of LBL-024 in advanced solid tumours, including esophageal squamous cell carcinoma (substudy 03), is currently recruiting.

• CLINICAL_TRIALS research · 2026-03-05
  Clinical Trial Update: Time-of-Day of Immunotherapy Infusion in Neoadjuvant Immunochemotherapy for Thoracic ESCC [Phase 2]

  Phase 2 trial update evaluating whether the time of day for immunotherapy infusion influences outcomes in neoadjuvant immunochemotherapy for…

• CLINICAL_TRIALS research · 2026-03-03
  Clinical Trial Update: A Phase III Study of First-line Anlotinib Combined With Benmelstobart in Patients With Advanced Esophageal Squamous Cell Carcinoma [Phase 3]

  A Phase III trial is evaluating first-line therapy with anlotinib in combination with benmelstobart for advanced esophageal squamous cell ca…

• CLINICAL_TRIALS research · 2026-03-03
  Clinical Trial Update: A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors [Phase 1, Phase 2]

  A Phase 1/2 clinical trial is evaluating ALE.P02 as monotherapy in adults with CLDN1+ solid tumors, including squamous cell carcinomas of th…

• CLINICAL_TRIALS research · 2026-03-02
  Clinical Trial Update: Effectiveness and Performance of an Optical Biopsy Technology for Esophageal Cancer in Brazil and the United States [Phase 2]

  A Phase 2 clinical study evaluating the effectiveness of an optical biopsy technology to detect esophageal squamous cell neoplasia, conducte…

• CLINICAL_TRIALS research · 2026-02-27
  Clinical Trial Update: Neoadjuvant Adebrelimab Plus Chemotherapy for Esophageal Cancer: A Clinical Study [Phase 2]

  This update notes an ongoing Phase 2 clinical trial evaluating neoadjuvant adebrelimab combined with chemotherapy for esophageal squamous ce…

• CLINICAL_TRIALS research · 2026-02-27
  Clinical Trial Update: Study of Tislelizumab Combined With Chemoradiotherapy and Surgery for Unresectable Esophageal Squamous Cell Carcinoma [Phase 2]

  Phase 2 study evaluating tislelizumab combined with chemoradiotherapy and surgery for unresectable esophageal squamous cell carcinoma, curre…

• CLINICAL_TRIALS research · 2026-02-27
  Clinical Trial Update: Exploratory Clinical Trial of Oral Paclitaxel Plus Radiotherapy in Patients With Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma [Phase 2]

  An exploratory Phase 2 clinical trial evaluating oral paclitaxel plus radiotherapy for locally advanced unresectable esophageal squamous cel…

• CLINICAL_TRIALS research · 2026-02-27
  Clinical Trial Update: Induction Immunochemotherapy Followed by Concurrent Chemoradiotherapy in Patients With ESCC. [Phase 2]

  An update on a Phase 2 trial evaluating induction immunochemotherapy followed by concurrent chemoradiotherapy in patients with esophageal sq…

• CLINICAL_TRIALS research · 2026-02-24
  Clinical Trial Update: Adebrelimab Combined With Chemotherapy for the Esophageal Squamous Cell Carcinoma [NA]

  A clinical trial evaluating adebrelimab in combination with chemotherapy for esophageal squamous cell carcinoma is currently recruiting.

• CLINICAL_TRIALS research · 2026-02-19
  Clinical Trial Update: Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination [Phase 1, Phase 2]

  Phase 1/2 trial update evaluating MCLA-129, a bispecific anti-EGFR and anti-c-MET antibody, in advanced non-small cell lung cancer and other…