Diffuse Midline Glioma H3 K27m-mutant
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma [Phase 1]
A Phase 1 trial evaluating Triapine in combination with radiation therapy for recurrent glioblastoma or astrocytoma has been suspended.
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant [Phase 2]
Phase 2 clinical trial exploring ribociclib with everolimus or with temozolomide for high-grade gliomas and related diffuse gliomas; recruit…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG [Phase 1]
This Phase 1 study evaluates rHSC-DIPGVax in combination with checkpoint blockade for newly diagnosed diffuse intrinsic pontine glioma and d…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0 [Phase 3]
A Phase 3 clinical trial evaluating a biological medicine for diffuse intrinsic pontine glioma and related diffuse midline gliomas is curren…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: FUS Etoposide for DMG [Phase 1]
Phase 1 trial investigating focused ultrasound-delivered etoposide for diffuse intrinsic pontine glioma and H3 K27M-mutant diffuse midline g…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study [Phase 2]
A Phase 2 Mayo Clinic trial is evaluating stereotactic biopsy followed by split-course radiation therapy for diffuse midline glioma with H3 …
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors [Phase 1]
Clinical trial update indicating that Loc3CAR (B7-H3-CAR T cells) delivery is in early-phase pediatric CNS tumor trials and currently recrui…
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CLINICAL_TRIALS trial_result · 2026-01-14Clinical Trial Update: A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors [Phase 1]
This Phase 1 clinical trial assesses the safety, dosing, and delivery of NEO100 in pediatric brain and CNS tumors and is not yet recruiting.
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms [Phase 1]
Phase I trial update indicates ONC206 is being studied for recurrent and rare primary central nervous system neoplasms and the study is curr…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Combination Therapy for the Treatment of Diffuse Midline Gliomas [Phase 2]
A Phase 2 clinical trial update describes a combination therapy for diffuse midline gliomas, including H3 K27M-mutant DMG and DIPG, with the…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification
This clinical trial update describes an observational study by the EORTC to assess treatment patterns and outcomes for patients with primary…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository
An international DIPG/DMG Registry and Repository study is currently recruiting to collect data and biospecimens for diffuse intrinsic ponti…
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CLINICAL_TRIALS trial_result · 2025-08-20Clinical Trial Update: Intermediate-size Expanded Access to ONC201 for Patients With H3 K27M-mutant and/or Midline Gliomas
This update describes an intermediate-size expanded access program for ONC201 in patients with H3 K27M-mutant diffuse midline glioma. The tr…
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: Atovaquone Combined With Radiation in Children With Malignant Brain Tumors [Phase 1]
A Phase 1 clinical trial evaluating atovaquone in combination with radiation for pediatric malignant brain tumors is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-01-22Clinical Trial Update: H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas [Phase 1, Phase 2]
Clinical trial results update for a combined H3.3K27M peptide vaccine and nivolumab in children with newly diagnosed Diffuse Intrinsic Ponti…
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CLINICAL_TRIALS trial_result · 2024-12-20Clinical Trial Update: A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG) [Phase 1]
Phase 1 trial evaluating BXQ-350 in children with newly diagnosed diffuse intrinsic pontine glioma and diffuse midline glioma (H3 K27M-mutan…
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CLINICAL_TRIALS trial_result · 2024-01-03Clinical Trial Update: Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas [Phase 1]
Phase 1 trial evaluating adavosertib with local radiation in children with newly diagnosed diffuse intrinsic pontine glioma; results are pos…