Cystic Fibrosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-08-28Clinical Trial Results: Sildenafil Exercise: Role of PDE5 Inhibition [Phase 2, Phase 3]
Phase 2/3 trial results for sildenafil as a PDE5 inhibitor assessing exercise-related outcomes in cystic fibrosis patients.
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EMA approval · 2026-08-19EMA Authorised: Kaftrio (ivacaftor;tezacaftor;elexacaftor) — Vertex Pharmaceuticals (Ireland) Limited
The EMA authorises Kaftrio (ivacaftor; tezacaftor; elexacaftor) for cystic fibrosis, with Vertex Pharmaceuticals (Ireland) Limited as the ma…
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EMA approval · 2026-08-19EMA Authorised: Alyftrek (deutivacaftor;tezacaftor;vanzacaftor calcium dihydrate) — Vertex Pharmaceuticals (Ireland) Limited
Alyftrek has been authorised in the EU for cystic fibrosis under Vertex Pharmaceuticals, with orphan designation.
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EMA approval · 2026-08-05EMA Authorised: Vantobra (previously Tobramycin PARI) (tobramycin) — Pari Pharma GmbH
EMA authorized Vantobra (tobramycin) for respiratory tract infections including cystic fibrosis; MAH Pari Pharma GmbH; decision date 15/07/2…
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EMA approval · 2026-07-31EMA Authorised: Kaftrio (ivacaftor;tezacaftor;elexacaftor) — Vertex Pharmaceuticals (Ireland) Limited
EMA authorised Kaftrio (ivacaftor; tezacaftor; elexacaftor) for cystic fibrosis, with orphan medicine designation.
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EMA approval · 2026-07-22EMA Authorised: Orkambi (Lumacaftor;ivacaftor) — Vertex Pharmaceuticals (Ireland) Limited
Orkambi (lumacaftor/ivacaftor) has been authorised by EMA for cystic fibrosis.
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CLINICAL_TRIALS trial_result · 2026-07-16Clinical Trial Results: A Phase 1b/2 Trial of the Safety and Microbiological Activity of Bacteriophage Therapy in Cystic Fibrosis Subjects Colonized With Pseudomonas Aeruginosa [Phase 1, Phase 2]
Phase 1b/2 clinical trial evaluating the safety and microbiological activity of bacteriophage therapy in cystic fibrosis patients colonized …
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CLINICAL_TRIALS trial_result · 2026-06-05Clinical Trial Update: Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Participants 12 Months of Age and Older [Phase 3]
A Phase 3 trial update assessing long-term safety and efficacy of ELX/TEZ/IVA (elexacaftor/tezacaftor/ivacaftor) in cystic fibrosis particip…
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CLINICAL_TRIALS trial_result · 2026-04-29Clinical Trial Results: Intrapulmonary Percussive Ventilation for Sputum Induction in Adults With Cystic Fibrosis [NA]
A completed clinical trial evaluating intrapulmonary percussive ventilation for sputum induction in adults with cystic fibrosis; results pos…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Role of Genetic Factors in the Development of Lung Disease
NHLBI-backed clinical trial is recruiting to study the role of genetic factors in the development of lung disease, including cystic fibrosis…
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease
This completed NHLBI study examined genetic disorders that affect mucociliary clearance in nontuberculous mycobacterial lung disease, includ…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders
A clinical trial update describes development of non-invasive prenatal diagnosis for single-gene disorders. The study, based in Paris, is cu…
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CLINICAL_TRIALS trial_result · 2026-04-23Clinical Trial Update: Increase Tolerance for Exercise and Raise Activity Through Connectedness Trial [NA]
A completed clinical trial evaluating increasing exercise tolerance and daily activity through connectedness in individuals with cystic fibr…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Prevalence of Exercise-induced Ventilatory Limitation and Associated Factors in Patients With Cystic Fibrosis Receiving Elexacaftor-Tezacaftor-Ivacaftor [NA]
This clinical trial status update indicates a recruiting study in cystic fibrosis patients treated with the triple CFTR modulator elexacafto…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Impact of Sinus Surgery on Individuals With Cystic Fibrosis
A UCLA-led clinical trial is investigating the impact of sinus surgery on individuals with cystic fibrosis and chronic rhinosinusitis and is…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Maralixibat in Patients With Cystic Fibrosis and Constipation [Phase 2, Phase 3]
This clinical trial update indicates that maralixibat is being studied in patients with cystic fibrosis and constipation, with Phase 2 and P…
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: Glycerol Phenylbutyrate Corrector Therapy For CF (Cystic Fibrosis) [Phase 1, Phase 2]
Phase 1/2 clinical trial of glycerol phenylbutyrate as a potential cystic fibrosis therapy was terminated; results have been posted.
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function [Phase 2]
Phase 2 trial evaluating metformin for people with cystic fibrosis-related diabetes on CFTR modulator therapy to improve ion channel functio…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: A Study to Test How Well BI 3720931 is Tolerated and Whether it Improves Lung Function in People With Cystic Fibrosis (Lenticlair™ 1) [Phase 1, Phase 2]
Boehringer Ingelheim's Lenticlair 1 trial of BI 3720931 in cystic fibrosis has been terminated in Phase 1/2, assessing tolerability and pote…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: An Intervention-Based Approach to Strengthen the Psychological Health of Children With Cystic Fibrosis and Their Mothers [NA]
A completed clinical trial evaluated an intervention-based program, including laughter yoga, to strengthen psychological health in children …
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: A Long-term Study to Monitor the Health Status of People With Cystic Fibrosis Who Took Part in a Previous Study With BI 3720931 (Lenticlair™-ON) [Phase 1, Phase 2]
A long-term follow-up study to monitor health status in people with cystic fibrosis who previously participated in a Boehringer Ingelheim tr…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Evaluation of VX-828 in Healthy Participants and in Participants With Cystic Fibrosis [Phase 1]
Phase 1 clinical trial evaluating VX-828 in healthy participants and in people with cystic fibrosis is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Natural History of Bronchiectasis
NHLBI-funded clinical trial update studying the natural history of bronchiectasis; the study is currently recruiting and includes bronchiect…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Bacterial Gene Profiling to Predict Antibiotic Resistance During Cystic Fibrosis Pulmonary Exacerbations
A completed clinical trial from National Jewish Health investigates using bacterial gene profiling to predict antibiotic resistance during c…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Observational Trial of the Longitudinal Effects of CFTR Modulator Drugs
This is an update on an observational study examining the long-term effects of CFTR modulator drugs in people with cystic fibrosis.