Rhinosinusitis with Nasal Polyps
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Tapering of Biologics in Chronic Rhinosinusitis With Nasal Polyps [Phase 4]
This Phase 4 clinical trial is investigating tapering strategies for biologics in chronic rhinosinusitis with nasal polyps and is currently …
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Implementation of a Joint Pulmonologist and ENT Consultation in the Care Pathway of Patients Suffering From Asthma and Chronic Rhinosinusitis With Nasal Polyposis: Effectiveness Compared With Consultations by Specialty (CON-PO Study). [NA]
A study analyzing a joint pulmonologist and ENT consultation pathway for asthma with chronic rhinosinusitis with nasal polyps, assessing eff…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis (CRS). [Phase 2, Phase 3]
Ongoing clinical trial update for a sinonasal microbiome transplant as a therapy for chronic rhinosinusitis, currently in Phase 2/3 and recr…
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CLINICAL_TRIALS trial_result · 2025-09-09Clinical Trial Update: Efficacy and Safety of Depemokimab (GSK3511294) in Participants With Chronic Rhinosinusitis With Nasal Polyps (ANCHOR-2) [Phase 3]
Phase 3 ANCHOR-2 trial results evaluate the efficacy and safety of depemokimab in participants with chronic rhinosinusitis with nasal polyps…
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CLINICAL_TRIALS trial_result · 2025-08-15Clinical Trial Update: A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Participants With Chronic Rhinosinusitis With Nasal Polyps [Phase 2]
This ClinicalTrials.gov entry reports the completion of a Phase 2 study evaluating Verekitug (UPB-101) for chronic rhinosinusitis with nasal…
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CLINICAL_TRIALS research · 2025-08-07Clinical Trial Update: CRS Questionnaire Validation Project
A clinical trial update announcing recruitment for a European project to validate a questionnaire for chronic rhinosinusitis with and withou…
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CLINICAL_TRIALS trial_result · 2025-07-30Clinical Trial Update: Tissue Immune Interaction in Nasal Polyposis
A completed clinical trial from the University of California, San Francisco examining tissue immune interactions in nasal polyposis (Chronic…
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CLINICAL_TRIALS research · 2025-07-18Clinical Trial Update: Study Assessing Long-teRm Outcomes of dupiluMAb (DUPIXENT®) Treatment in Adult Patients With Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)
The clinical trial investigates long-term outcomes of dupilumab (DUPIXENT) in adults with chronic rhinosinusitis with nasal polyps; the stud…
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CLINICAL_TRIALS trial_result · 2025-07-14Clinical Trial Update: A Clinical Study of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps. [Phase 2]
Phase 2 clinical study of TQH2722 Injection for chronic sinusitis with or without nasal polyps has completed.
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: Long-term Effect of Dupilumab in N-ERD
This trial update discusses the long-term effects of dupilumab in aspirin-exacerbated respiratory disease (AERD). It covers conditions such …
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CLINICAL_TRIALS research · 2025-07-01Clinical Trial Update: Effect of Tezepelumab on Barrier Function in Severe Asthmatic Patients With and Without Comorbid Chronic Rhinosinusitis With Nasal Polyps [NA]
This clinical trial update evaluates tezepelumab’s effect on barrier function in severe asthma patients, with and without chronic rhinosinus…
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CLINICAL_TRIALS trial_result · 2025-07-01Clinical Trial Update: A Real-world, Head-to-head Comparison of Dupilumab Versus Mepolizumab in Danish Patients With Chronic Rhinosinusitis With Nasal Polyps [Phase 4]
Phase 4 real-world head-to-head trial in Danish patients compares dupilumab with mepolizumab for chronic rhinosinusitis with nasal polyps an…
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CLINICAL_TRIALS research · 2025-06-04Clinical Trial Update: The German National CRS Registry (GenreCRS): Clinical Evaluation of the New European Academy for Allergy and Clinical Immunology (EAACI) Criteria for CRSwNP Disease Control, Remission and Cure in a Real-World Evidence Study Approach
This clinical trial registry entry describes a real-world study evaluating EAACI criteria for disease control, remission, and cure in chroni…
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CLINICAL_TRIALS research · 2025-05-14Clinical Trial Update: Olfactory Cleft Obstruction and Electrophysiological Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.
A clinical trial update describes a study evaluating whether olfactory cleft obstruction and electrophysiological field potentials can predi…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Moving Towards Precision Medicine in United Airways Disease: Unraveling Inflammatory Patterns in Asthmatic Patients With or Without Nasal Polyps [NA]
Clinical trial update on a Medical University of Vienna study exploring precision medicine in United Airways Disease, examining inflammatory…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Effect of Dupilumab on Nasal Epithelial Barrier Function in Patients With CRSwNP
An ongoing clinical trial is evaluating the effect of dupilumab on nasal epithelial barrier function in patients with chronic rhinosinusitis…
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: A Clinical Study of TQC2731 Injection in the Treatment of Chronic Rhinosinusitis With Nasal Polyps [Phase 2]
A Phase 2 clinical trial evaluating TQC2731 injection for chronic rhinosinusitis with nasal polyps has completed.
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CLINICAL_TRIALS research · 2025-04-16Clinical Trial Update: A Study of CM512 in Patients With Chronic Rhinosinusitis With Nasal Polyposis （NEZHA-1） [Phase 2]
A Phase 2 clinical trial evaluating CM512 in chronic rhinosinusitis with nasal polyps (NEZHA-1). The study is not yet recruiting.
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CLINICAL_TRIALS research · 2025-04-08Clinical Trial Update: International Severe CRSwNP Registry 2024-2028
This document is an update on the International Severe CRSwNP Registry (NCT06617754) for chronic rhinosinusitis with nasal polyps, showing t…
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CLINICAL_TRIALS trial_result · 2025-04-01Clinical Trial Update: Interleukin-4Ra Blockade by Dupilumab Decreases Staphylococcus Colonization and Increases Microbial Diversity in CRSwNP [Phase 4]
A Phase 4 trial update shows that dupilumab, by blocking IL-4 receptor alpha, reduces Staphylococcus aureus colonization and increases micro…
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CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: Mepolizumab to CRSwNP Through 12 Months - Randomised to FESS and Non-FESS Within the First 2 Weeks [Phase 4]
A Phase 4 clinical trial update for mepolizumab in chronic rhinosinusitis with nasal polyps (CRSwNP), comparing outcomes through 12 months i…
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CLINICAL_TRIALS trial_result · 2025-03-26Clinical Trial Update: Safety and Efficacy of BHV-3000 (Rimegepant) Orally Disintegrating Tablet for the Acute Treatment of Chronic Rhinosinusitis [Phase 3]
Phase 3 trial evaluating the safety and efficacy of BHV-3000 (rimegepant) orally disintegrating tablet for acute treatment of chronic rhinos…
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CLINICAL_TRIALS research · 2025-03-21Clinical Trial Update: 3D Printing to Improve Nasal Irrigation Outcome [NA]
A clinical trial sponsored by Ohio State University is evaluating whether 3D-printed nasal irrigation devices improve outcomes in chronic rh…
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CLINICAL_TRIALS research · 2025-03-18Clinical Trial Update: Aggravated Airway Inflammation: Research on Genomics and Optimal Operative Treatment (AirGOs Operative) [NA]
A completed clinical trial (NCT03704415) investigating genomics and optimal operative treatment for chronic airway inflammation in chronic r…
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CLINICAL_TRIALS research · 2025-02-14Clinical Trial Update: Identifying Predictors Of Response To Mepolizumab In CRSwNP [Phase 4]
Phase 4 trial identifying predictors of response to mepolizumab in chronic rhinosinusitis with nasal polyps (CRSwNP). Recruitment is ongoing…