Central Nervous System Tumors
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors [Phase 2]
A Phase 2 trial evaluating Entrectinib as a single-agent upfront therapy for children under 3 with NTRK1/2/3 or ROS1-fused CNS tumors is cur…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study of PHST001 in Advanced Solid Tumors [Phase 1]
Pheast Therapeutics is recruiting for a Phase 1 study of PHST001 in patients with advanced solid tumors, including ovarian cancer, endometri…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study of Mirdametinib in People With Central Nervous System Tumors [Phase 1, Phase 2]
This document provides an update on an ongoing Phase 1/Phase 2 clinical trial evaluating Mirdametinib in people with central nervous system …
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials [NA]
A clinical trial update describing efforts to improve adolescent and young adult self-reported data in ECOG-ACRIN trials, with trials curren…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors [NA]
Observational study in recurrent central nervous system tumors to evaluate responses to various treatments in brain tumors, with ongoing rec…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options [Phase 1, Phase 2]
Ongoing pediatric study of entrectinib (Rxdx-101) for locally advanced or metastatic solid tumors and/or primary CNS tumors with no satisfac…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Sirolimus in Combination With Metronomic Chemotherapy in Children With Recurrent and/or Refractory Solid and CNS Tumors [Phase 2]
A Phase 2 clinical trial investigates sirolimus in combination with metronomic chemotherapy in children with recurrent or refractory solid t…
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CLINICAL_TRIALS research · 2026-02-11Clinical Trial Update: Intraoperative Use of I.V. Sodium Fluorescein in Suspected CNS Tumors
This clinical trial updates the use of intravenous sodium fluorescein during surgery for suspected central nervous system tumors and is curr…
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors [Phase 1]
A phase 1 trial evaluating the safety of combining avelumab with lenvatinib in children with central nervous system tumors; the study is act…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors [Phase 1]
Phase 1 trial evaluating locoregional HER2-targeted CAR T-cell therapy for pediatric recurrent or refractory central nervous system tumors a…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: 68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors. [Phase 4]
A Phase 4 clinical trial evaluating the use of the radiotracer 68-Gallium DOTATATE PET/MRI for diagnosing and managing somatostatin receptor…
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CLINICAL_TRIALS research · 2025-10-16Clinical Trial Update: Next Generation Sequencing of Normal Tissues Prospectively in Pediatric Oncology Patients
St. Jude Children's Research Hospital is conducting a prospective study to perform next-generation sequencing on normal tissues in pediatric…
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CLINICAL_TRIALS trial_result · 2025-08-05Clinical Trial Update: POWER UP: Participating Online While Exercising to Recover Using Play [NA]
A clinical trial called POWER UP studying online participation during exercise to help recovery for central nervous system tumors has been t…
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CLINICAL_TRIALS research · 2025-07-25Clinical Trial Update: OH2 Oncolytic Viral Therapy in Central Nervous System Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial of OH2 Oncolytic Viral Therapy for central nervous system tumors is currently recruiting.
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CLINICAL_TRIALS research · 2025-04-29Clinical Trial Update: Computer-based Neurocognitive Assessment in Children With Central Nervous System Tumors Receiving Proton Beam Radiation Therapy
This clinical trial update indicates a study evaluating computer-based neurocognitive assessment in children with central nervous system tum…
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CLINICAL_TRIALS trial_result · 2025-04-09Clinical Trial Update: A Nomogram for Predicting the Diagnosis of Central Malignant Tumors Based on Preoperative Clinical Characteristics and Laboratory Indicators:
A completed clinical trial evaluates a nomogram based on preoperative clinical characteristics and laboratory indicators to predict diagnose…
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CLINICAL_TRIALS trial_result · 2025-03-19Clinical Trial Update: Phase 2 STIR Trial: Haploidentical Transplant and Donor Natural Killer Cells for Solid Tumors [Phase 2]
Phase 2 trial update of haploidentical transplantation with donor natural killer cells for solid tumors; the study was terminated and result…
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CLINICAL_TRIALS trial_result · 2025-02-28Clinical Trial Update: Feasibility of Using Bortezomib With or Without Chemotherapy in Patients With Atypical Teratoid/Rhabdoid Tumors [Phase 2]
Phase 2 trial update evaluating the feasibility of adding bortezomib, with or without standard chemotherapy, in patients with atypical terat…
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CLINICAL_TRIALS trial_result · 2024-10-09Clinical Trial Update: REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma [Phase 1, Phase 2]
Regeneron’s cemiplimab (REGN2810) was studied in pediatric patients with relapsed/refractory solid tumors and CNS tumors, including a safety…
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CLINICAL_TRIALS trial_result · 2024-03-20Clinical Trial Update: A Study of TAS-120 in Patients With Advanced Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 study of futibatinib (TAS-120) in patients with advanced solid tumors, including cholangiocarcinoma, urothelial carcinoma, breas…
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CLINICAL_TRIALS trial_result · 2023-08-30Clinical Trial Update: Study of Lenvatinib in Combination With Everolimus in Recurrent and Refractory Pediatric Solid Tumors, Including Central Nervous System Tumors [Phase 1, Phase 2]
A Phase 1/2 study evaluating lenvatinib in combination with everolimus for pediatric patients with recurrent and refractory solid tumors, in…
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CLINICAL_TRIALS trial_result · 2023-03-30Clinical Trial Update: Nanoparticle Albumin-Bound Rapamycin, Temozolomide, and Irinotecan Hydrochloride in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors [Phase 1]
Phase 1 pediatric trial evaluating a triple combination of nanoparticle albumin-bound rapamycin, temozolomide, and irinotecan for recurrent …
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CLINICAL_TRIALS trial_result · 2021-10-27Clinical Trial Update: Indocyanine Green for Central Nervous System Tumors [Phase 1, Phase 2]
A completed Phase 1/2 clinical trial evaluating indocyanine green for suspected central nervous system tumors; results posted in 2021.
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CLINICAL_TRIALS trial_result · 2021-08-13Clinical Trial Update: Modafinil in Treating Children With Memory and Attention Problems Caused by Cancer Treatment for a Brain Tumor [Phase 2]
A Phase 2 trial evaluated modafinil for memory and attention problems in children after cancer treatment for brain tumors; results have been…
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CLINICAL_TRIALS trial_result · 2021-04-05Clinical Trial Update: Study of Lenalidomide With Vorinostat in Pediatric Patients With High Grade or Progressive CNS Tumors [Phase 1]
Phase 1 trial evaluating lenalidomide with vorinostat in pediatric high-grade or progressive CNS tumors; study terminated with results poste…