Brain Metastases
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Neurocognitive Decline in Patients With Brain Metastases [Phase 1, Phase 2]
The document outlines a Phase 1/2 clinical trial evaluating neurocognitive decline in patients with brain metastases. The study is currently…
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CLINICAL_TRIALS trial_result · 2026-03-25Clinical Trial Update: Binimetinib Encorafenib Pembrolizumab +/- Stereotactic Radiosurgery in BRAFV600 Melanoma With Brain Metastasis [Phase 2]
A Phase 2 clinical trial evaluating a combination of binimetinib, encorafenib, and pembrolizumab, with or without stereotactic radiosurgery,…
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: Analyzing Preoperative Stereotactic Radiosurgery With Gamma Knife Icon for Brain Metastases [NA]
A completed clinical trial evaluated preoperative stereotactic radiosurgery with the Gamma Knife Icon device for brain metastases, and resul…
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CLINICAL_TRIALS trial_result · 2026-03-20Clinical Trial Update: Blood Brain Barrier Disruption (BBBD) Using MRgFUS in the Treatment of Her2-positive Breast Cancer Brain Metastases [NA]
This completed clinical trial evaluated blood-brain barrier disruption using MR-guided focused ultrasound in HER2-positive breast cancer pat…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance [Phase 2]
Phase 2 trial evaluating MRI surveillance to reduce symptomatic brain metastases in patients with stage III non-small cell lung cancer.
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases [Phase 2]
Phase 2 trial evaluating stereotactic brain-directed radiation with or without Aguix gadolinium-based nanoparticles for brain metastases; th…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases [Phase 2]
Phase 2 clinical trial evaluating prophylactic anti-seizure medication versus no anti-seizure medication in patients with primary motor cort…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases [NA]
Clinical trial evaluating imaging-based treatment response assessment to distinguish necrosis from tumor after stereotactic radiation in bra…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction [Phase 2]
Phase 2 clinical trial evaluating same-day planning and margin-reduced stereotactic radiation for growing or changing brain metastases. The …
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastases [Phase 1, Phase 2]
A Phase 1/2 trial evaluating Bintrafusp alfa in combination with Pimasertib for brain metastases has been terminated, with results posted in…
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CLINICAL_TRIALS trial_result · 2026-03-17Clinical Trial Update: Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases [Phase 2]
Phase 2 trial evaluating osimertinib with or without bevacizumab in EGFR-positive non-small cell lung cancer with brain metastases; results …
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: Secondary BRain Metastases Prevention After Isolated Intracranial Progression on Trastuzumab/Pertuzumab or T-DM1 in Patients With aDvanced Human Epidermal Growth Factor Receptor 2+ brEast Cancer With the Addition of Tucatinib [Phase 2]
This Phase 2 trial investigates adding tucatinib to trastuzumab/pertuzumab or T-DM1 to prevent brain metastases in patients with advanced HE…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: CSF and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and CNS Metastases or no CNS Metastases [NA]
A clinical trial evaluating CSF and blood plasma liquid biopsy in patients with metastatic solid tumors, with and without brain metastases o…
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CLINICAL_TRIALS other · 2026-03-17Clinical Trial Update: Meclofenamate in Subjects With Recurrent or Progressive Brain Metastasis From Solid Tumor Primary [NA]
Clinical trial registry entry for meclofenamate in recurrent or progressive brain metastases from solid tumors; trial status is ACTIVE_NOT_R…
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CLINICAL_TRIALS trial_result · 2026-03-16Clinical Trial Update: TraStuzumAb-Radiotherapy : Impact on the Cerebral Prevention [Phase 3]
A Phase 3 trial evaluating trastuzumab with radiotherapy to prevent brain metastases in breast cancer has been terminated.
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CLINICAL_TRIALS trial_result · 2026-03-16Clinical Trial Update: Prospective Assessment of Quality of Life in Patients Treated by Radiosurgery for Brain Metastases (PRAMECE-1302) [NA]
The Prospective Assessment of Quality of Life in Patients Treated by Radiosurgery for Brain Metastases (PRAMECE-1302) trial, which evaluated…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Palbociclib and Pembrolizumab In Central Nervous System Metastases [Phase 2]
Phase 2 clinical trial update evaluating the combination of palbociclib and pembrolizumab for brain metastases; the study is currently recru…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal Cancers
This clinical trial update describes a study comparing the molecular-genetic profiles of primary gastroesophageal tumors with their brain me…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: T-DXd Therapy for HER2-low Breast Cancer Patients With Brain Metastases [Phase 2]
Phase 2 clinical trial update for trastuzumab deruxtecan (Enhertu) in HER2-low breast cancer patients with brain metastases, currently activ…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: The CyberChallenge Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases? [NA]
This clinical trial update discusses the role of CyberKnife radiosurgery for patients with multiple brain metastases, including individuals …
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CLINICAL_TRIALS trial_result · 2026-03-09Clinical Trial Update: Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases [Phase 1]
This phase 1 study assessed pembrolizumab in combination with stereotactic radiosurgery for patients with brain metastases from melanoma or …
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain Metastases [Phase 3]
Phase 3 clinical trial comparing stereotactic radiosurgery to whole-brain radiation therapy for newly diagnosed brain metastases; currently …
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM) [Phase 2]
Phase 2 trial LaSAR BeaM evaluating Laser Interstitial Thermal Therapy or surgical resection with adjuvant reirradiation for recurrent brain…
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: CBF and NCF Changes With Brain Radiation
This clinical trial update discusses cerebral blood flow and neurocognitive function changes associated with brain radiation in patients wit…
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases [Phase 1]
A Phase 1 study of trastuzumab deruxtecan in combination with stereotactic radiosurgery for HER2-positive breast cancer with brain metastase…