Brain Metastases
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-08-05Clinical Trial Update: Precise DCE-MRI in Diagnosing Participants With Recurrent High Grade Glioma or Melanoma Brain Metastases [NA]
This update notes a terminated clinical trial at the University of Southern California evaluating precise dynamic contrast-enhanced MRI (DCE…
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CLINICAL_TRIALS trial_result · 2025-07-24Clinical Trial Update: Lorlatinib in ROS1+ NSCLC With Brain Metastasis [Phase 2]
Lorlatinib is being studied in a Phase 2 trial for ROS1-positive non-small cell lung cancer with brain metastases, which is currently not ye…
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CLINICAL_TRIALS trial_result · 2025-07-23Clinical Trial Update: X-396(Ensartinib) Capsules in ALK-Positive NSCLC Patients With Brain Metastases [Phase 2]
Phase 2 study update of X-396 (ensartinib) in ALK-positive non-small cell lung cancer patients with brain metastases. The trial status is ac…
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CLINICAL_TRIALS trial_result · 2025-07-20Clinical Trial Update: Stereotactic Radiosurgery in Treating Patients With Large Brain Metastases [Phase 1]
A Phase 1 clinical trial evaluating stereotactic radiosurgery for patients with large brain metastases; the study is currently active but no…
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CLINICAL_TRIALS trial_result · 2025-07-18Clinical Trial Update: Pre- Versus Post-operative SRS for Resectable Brain Metastases [Phase 3]
A Phase 3 trial comparing pre-operative versus post-operative stereotactic radiosurgery for resectable brain metastases has been terminated.
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CLINICAL_TRIALS trial_result · 2025-06-27Clinical Trial Update: Accelerated Checkpoint Therapy for Any Steroid Dependent Patient With Brain Metastases [Phase 2]
This document provides a Phase 2 clinical trial update that accelerated checkpoint therapy for adult patients with brain metastases has been…
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CLINICAL_TRIALS trial_result · 2025-06-26Clinical Trial Update: Pre-operative Stereotactic Radiosurgery Followed by Resection for Brain Metastases [NA]
This trial update reports completion and posted results for a study evaluating pre-operative stereotactic radiosurgery followed by surgical …
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CLINICAL_TRIALS trial_result · 2025-06-24Clinical Trial Update: DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] Disease [Phase 2]
Phase 2 results update for DS-8201a (trastuzumab deruxtecan) in advanced HER2-positive breast cancer, including patients with brain metastas…
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CLINICAL_TRIALS trial_result · 2025-06-06Clinical Trial Update: Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery [Phase 3]
Phase 3 trial comparing hippocampus-sparing whole-brain radiotherapy to stereotactic radiosurgery for patients with brain metastases from va…
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CLINICAL_TRIALS trial_result · 2025-05-29Clinical Trial Update: RTA 744 in Breast Cancer Patients With Progression of Previously Irradiated Brain Metastases [Phase 2]
Phase 2 trial of RTA 744 in breast cancer patients with progression of previously irradiated brain metastases has been terminated.
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Fractionated Stereotactic Radiosurgery for Large Brain Metastases [NA]
Clinical trial update reporting results for fractionated stereotactic radiosurgery in patients with large brain metastases; results were pos…
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CLINICAL_TRIALS trial_result · 2025-05-22Clinical Trial Update: Whole Brain Radiation Using IMRT for Patients With Brain Metastases [NA]
The clinical trial evaluating whole-brain radiation therapy using IMRT for brain metastases has completed.
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CLINICAL_TRIALS trial_result · 2025-05-16Clinical Trial Update: A Dose Escalation Trial of Five Fraction Stereotactic Radiation Therapy for Brain Metastases [NA]
This completed dose-escalation trial studied five-fraction stereotactic radiation therapy for brain metastases, and results have been posted…
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CLINICAL_TRIALS trial_result · 2025-05-14Clinical Trial Update: Survivorship Study of Cancer Patients Who Received Cranial Radiation Therapy
This clinical trial update reports that the Duke University–sponsored survivorship study of cancer patients who received cranial radiation t…
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CLINICAL_TRIALS trial_result · 2025-05-13Clinical Trial Update: Encorafenib and Binimetinib Before Local Treatment in Patients With BRAF Mutant Melanoma Metastatic to the Brain [Phase 2]
Phase 2 study evaluating encorafenib and binimetinib before local treatment in patients with BRAF-mutant melanoma that has spread to the bra…
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: Combination of Sorafenib and Radiation for Brain Metastases and Primary Brain Tumors [Phase 1]
A completed Phase 1 trial evaluating the safety and tolerability of combining sorafenib with radiation therapy in patients with brain metast…
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: Neurosurgical Transitional Care Programme [NA]
The study NCT03593330 evaluating a Neurosurgical Transitional Care Programme at Barts & The London NHS Trust has been terminated.
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CLINICAL_TRIALS trial_result · 2025-04-23Clinical Trial Update: Evaluation of the Efficacy and Safety of Nal-IRI for Progressing Brain Metastases in Breast Cancer Patients [Phase 2]
This document reports the completion of a Phase 2 trial evaluating liposomal irinotecan (Nal-IRI) for brain metastases in breast cancer pati…
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CLINICAL_TRIALS trial_result · 2025-04-17Clinical Trial Update: RAPid SimPLE Targeted Radiation Treatment for Brain Metastases [Phase 2]
Phase 2 clinical trial update for RAPid SimPLE Targeted Radiation Treatment in brain metastases; the study is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-04-09Clinical Trial Update: Managing Distress in Malignant Brain Cancer [NA]
The document reports completion and posted results for a clinical trial focused on distress management in adults with brain metastases.
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CLINICAL_TRIALS trial_result · 2025-04-09Clinical Trial Update: Nivolumab and Ipilimumab Plus Chemotherapy for Patients With Stage IV Lung Cancer With Brain Metastases [Phase 2]
A Phase 2 trial of nivolumab and ipilimumab with chemotherapy for stage IV non-small cell lung cancer with brain metastases is currently act…
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CLINICAL_TRIALS trial_result · 2025-03-20Clinical Trial Update: Phase 2 Trial in Multiple Brain Metastases Outcomes With HA-SIB-WBRT [Phase 2]
Phase 2 trial evaluating hippocampus-avoidance simultaneous integrated boost whole-brain radiotherapy for patients with multiple brain metas…
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CLINICAL_TRIALS trial_result · 2025-03-11Clinical Trial Update: Multicenter Retrospective Study on Patients Treated with Stereotactic Radiosurgery/Radiotherapy for Single Brain Lesions: Evaluation of Treatment Efficacy and Safety, Also Through Radiomic Analysis Methods.
A multicenter retrospective study evaluating the efficacy and safety of stereotactic radiosurgery/radiotherapy for a single brain lesion, wi…
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CLINICAL_TRIALS trial_result · 2025-03-05Clinical Trial Update: A Phase II Study of Pre-Op SRS Followed by Surgical Resection for Brain Metastases [NA]
Phase II study evaluating pre-operative stereotactic radiosurgery followed by surgical resection for brain metastases. The study is currentl…
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CLINICAL_TRIALS trial_result · 2025-02-13Clinical Trial Update: A Trial Evaluating Concurrent Whole Brain Radiotherapy and Iniparib in Multiple Non Operable Brain Metastases [Phase 1]
A Phase 1 trial evaluating concurrent whole-brain radiotherapy and Iniparib in patients with multiple non-operable brain metastases has been…