Brain Metastases
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-01-22Clinical Trial Update: GDC-0084 in Combination With Trastuzumab for Patients With HER2-Positive Breast Cancer Brain Metastases [Phase 2]
Phase 2 trial evaluating GDC-0084 in combination with trastuzumab for HER2-positive breast cancer with brain metastases has been terminated.
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CLINICAL_TRIALS trial_result · 2026-01-09Clinical Trial Update: Low Dose Ipilimumab With Pembrolizumab in Treating Patients With Melanoma That Has Spread to the Brain [Phase 2]
A Phase 2 trial evaluating low-dose ipilimumab in combination with pembrolizumab for metastatic melanoma with brain metastases has completed…
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CLINICAL_TRIALS trial_result · 2025-12-31Clinical Trial Update: Tucatinib, Trastuzumab, and Capecitabine With SRS for Brain Metastases From HER-2 Positive Breast Cancer [Phase 1]
A Phase 1 trial evaluating tucatinib, trastuzumab, and capecitabine with stereotactic radiosurgery for brain metastases in HER2-positive bre…
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CLINICAL_TRIALS trial_result · 2025-12-29Clinical Trial Update: Frameless Stereotactic Radiosurgery for Intact Brain Metastases [Phase 2]
A Phase 2 clinical trial is evaluating frameless stereotactic radiosurgery for intact brain metastases, and the study is currently recruitin…
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CLINICAL_TRIALS trial_result · 2025-12-26Clinical Trial Update: Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent [Phase 2]
Phase 2 ascending-dose study of RVP-001, a manganese-based MRI contrast agent, completed to assess safety and preliminary efficacy in CNS le…
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CLINICAL_TRIALS trial_result · 2025-12-17Clinical Trial Update: Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma [Phase 2]
A Phase 2 clinical trial update evaluating two combination regimens for BRAFV600-mutant metastatic or unresectable melanoma: nivolumab with …
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CLINICAL_TRIALS trial_result · 2025-12-04Clinical Trial Update: Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases [Phase 1]
Phase 1 clinical trial evaluating the combination of stereotactic radiation and nivolumab for metastatic breast cancer with brain metastases…
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CLINICAL_TRIALS trial_result · 2025-12-04Clinical Trial Update: Preoperative Stereotactic Radiosurgery for Brain Metastases [Phase 2]
Phase 2 clinical trial evaluating preoperative stereotactic radiosurgery for brain metastases has completed.
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CLINICAL_TRIALS trial_result · 2025-11-24Clinical Trial Update: Evaluation of the Humoral and Tumoral Molecular Alteration Profile of Brain Metastases [NA]
This clinical trial update reports the completed evaluation of humoral and tumoral molecular alterations in brain metastases.
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CLINICAL_TRIALS trial_result · 2025-11-18Clinical Trial Update: Dynamic F-DOPA PET for Differential Diagnosis Between Recurrence and Radionecrosis of Brain Metastasis [NA]
Completed clinical trial evaluating dynamic F-DOPA PET to differentiate recurrence from radionecrosis in patients with brain metastases.
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Treatment With Tucatinib in Patients With an Isolated Brain Progression of a Metastatic Breast Cancer [Phase 2]
Phase 2 trial evaluating tucatinib for metastatic breast cancer with isolated brain progression. The study status is active but not recruiti…
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CLINICAL_TRIALS trial_result · 2025-10-31Clinical Trial Update: Pivotal, Open-label, Randomized Study of Radiosurgery With or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases From Non-small Cell Lung Cancer (NSCLC). [Phase 3]
A pivotal Phase 3 trial evaluated adding Tumor Treating Fields (TTFields) to radiosurgery for patients with 1-10 brain metastases from non-s…
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CLINICAL_TRIALS trial_result · 2025-10-15Clinical Trial Update: MW151 and Whole-brain Radiotherapy in Patients With Intracranial Metastases [Phase 1]
Phase 1 trial update of MW151 in combination with whole-brain radiotherapy for patients with brain metastases, focusing on cognitive outcome…
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CLINICAL_TRIALS trial_result · 2025-10-08Clinical Trial Update: CALM: Managing Distress in Malignant Brain Cancer [NA]
This document reports a completed update for the CALM trial focused on managing distress in patients with malignant brain cancer.
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: Allogeneic, Antigen-Presenting, GM-CSF-secreting, SV-BR-1-GM Whole Cell-Therapeutic Vaccine and Immunotherapy: A Phase I Pilot Safety and Feasibility Study for Solid Tumor Patients With CNS Metastases [Phase 1]
A Phase I pilot safety and feasibility study of the SV-BR-1-GM whole-cell vaccine for solid tumors with CNS metastases (brain metastases and…
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CLINICAL_TRIALS trial_result · 2025-09-29Clinical Trial Update: Sacituzumab Tirumotecan (Sac-TMT) Plus Bevacizumab in 3rd Generation EGFR-TKI Treated Advanced EGFR-mutant Nonsquamous NSCLC With Brain Metastasis [Phase 2]
This Phase 2 trial evaluates sacituzumab tirumotecan plus bevacizumab in advanced EGFR-mutant nonsquamous non-small cell lung cancer with br…
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CLINICAL_TRIALS trial_result · 2025-09-24Clinical Trial Update: HyperArc Registry Study
The HyperArc Registry Study sponsored by Varian (a Siemens Healthineers company) has completed, evaluating HyperArc for brain metastases and…
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CLINICAL_TRIALS trial_result · 2025-09-10Clinical Trial Update: First Line Treatment in EGFR Mutation Positive Advanced NSCLC Patients With Central Nervous System (CNS) Metastases [Phase 2, Phase 3]
Clinical trial update indicating the completion of a Phase 2/3 study evaluating first-line treatment for EGFR mutation-positive advanced non…
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CLINICAL_TRIALS trial_result · 2025-08-28Clinical Trial Update: Study to Establish the Diagnostic Performance of 18F Fluciclovine PET in Detecting Recurrent Brain Metastases [Phase 3]
A Phase 3 study evaluating the diagnostic performance of 18F-fluciclovine PET for detecting recurrent brain metastases has completed and pos…
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CLINICAL_TRIALS trial_result · 2025-08-20Clinical Trial Update: Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Brain Metastases Trial [NA]
A clinical trial evaluating magnetic resonance-guided laser interstitial thermal therapy for brain metastases has completed.
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CLINICAL_TRIALS trial_result · 2025-08-19Clinical Trial Update: E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanoma [Phase 1]
Phase 1 study evaluating E6201 in combination with dabrafenib for central nervous system metastases from BRAF V600-mutated metastatic melano…
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CLINICAL_TRIALS trial_result · 2025-08-17Clinical Trial Update: Pemetrexed/Platinum With or Without Bevacizumab in Brain Metastases From Patients With EGFR/ALK Negative Non-Squamous Non-small Cell Lung Cancer [Phase 3]
A Phase 3 trial evaluating pemetrexed/platinum with or without bevacizumab in patients with EGFR/ALK-negative non-squamous non-small cell lu…
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CLINICAL_TRIALS trial_result · 2025-08-12Clinical Trial Update: 7T MRI Scan for the Early Detection of Melanoma Brain Metastases [NA]
A terminated clinical trial evaluating 7T MRI for the early detection of brain metastases in patients with stage IV cutaneous melanoma.
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CLINICAL_TRIALS trial_result · 2025-08-08Clinical Trial Update: Evaluation of Cabozantinib in Metastatic Renal Cell Carcinoma (mRCC) With Brain Metastases [Phase 2]
Phase 2 trial evaluating cabozantinib in metastatic renal cell carcinoma with brain metastases has completed.
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer (NSCLC) [Phase 2]
Phase 2 trial evaluating pembrolizumab in combination with bevacizumab for treatment of brain metastases in metastatic melanoma or non-small…