Brain Metastases
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors [NA]
An MD Anderson Cancer Center trial is recruiting to evaluate electrocorticography for mapping functional brain areas during brain tumor surg…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain [Phase 1]
Phase 1 study evaluating the combination of cabozantinib and nivolumab with radiation therapy for metastatic renal cell carcinoma with brain…
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CLINICAL_TRIALS research · 2025-11-13Clinical Trial Update: Stereotactic Magnetic Resonance Guided Radiation Therapy [NA]
Clinical trial update on stereotactic MR-guided radiation therapy for multiple cancer types; recruitment is ongoing.
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM) [Phase 1]
Phase 1 trial PRISM investigates personalized radiotherapy for extensive-stage small cell lung cancer with brain metastases; recruitment is …
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating nivolumab with radiation therapy, with or without ipilimumab, for brain metastases arising from non-smal…
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CLINICAL_TRIALS research · 2025-10-15Clinical Trial Update: Trial of Differential Margins in Single Isocenter Radiosurgery of Brain Metastases [NA]
A clinical trial update for a radiation therapy study on differential margins in single isocenter radiosurgery for brain metastases; the stu…
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity [Phase 3]
Phase 3 dual observational and randomized cohort study (S1501) evaluating patients with metastatic HER2-positive breast cancer at risk of ca…
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study) [Phase 3]
Phase 3 study comparing post-surgical stereotactic radiotherapy (SRT) to GammaTile-ROADS for brain metastases; status indicates the trial is…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors With or Without Brain Metastases [Phase 1]
This update describes the first-in-human Phase 1 trial of AO-252, an oral TACC3 protein-protein interaction inhibitor, in patients with adva…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: Encorafenib and biNimetinib Followed by CEmiplimab and FiAnLimab in Patients With BRAF Mutant melanOma and Symptomatic Brain Metastases [Phase 2]
A Phase 2 clinical trial evaluating initial therapy with encorafenib and binimetinib followed by cemiplimab and fianlimab in patients with B…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: AI-assisted Diagnosis of Malignant Brain Tumors
An AI-assisted diagnostic study for malignant brain tumors is currently recruiting at Zhejiang University. The trial focuses on leveraging A…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: ioMRI in the Surgery of Brain Metastases. [NA]
An ongoing clinical trial is evaluating the use of intraoperative MRI (ioMRI) to guide surgery for brain metastases at the Technical Univers…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer) [Phase 2]
Phase 2 single-arm trial evaluating the combination of Datopotamab Deruxtecan, carboplatin, and pembrolizumab for treatment-naive brain meta…
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: Study Comparing Investigational Drug HBI-8000 + Nivolumab vs. Placebo + Nivolumab in Patients With Advanced Melanoma [Phase 3]
A Phase 3 trial is evaluating HBI-8000 plus nivolumab versus placebo plus nivolumab in advanced unresectable or metastatic melanoma, includi…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Mechanistic Study of SPARC-Mediated Regulation of Neutrophil Extracellular Trap Formation in the Brain Metastatic Microenvironment of Breast Cancer
A mechanistic study investigating SPARC's regulation of neutrophil extracellular trap formation in the brain metastasis microenvironment of …
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Dual Energy CT - a Tool for Delineation of Tumor and Organs at Risk in Radiotherapy
A clinical trial evaluating Dual Energy CT to delineate tumors and organs at risk in radiotherapy planning; the study is not yet recruiting.
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets
This clinical trial investigates MRI biomarkers of radiation-induced neurocognitive decline following stereotactic radiosurgery for newly di…
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases [Phase 1, Phase 2]
This is a two-cohort Phase 1/Phase 2 study evaluating SHR-A1811 for HER2-positive breast cancer with brain metastases.
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases [EARLY_Phase 1]
A phase 1 trial is evaluating arginine in combination with whole-brain radiation therapy for brain metastases and is currently recruiting.
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI [Phase 2]
Clinical trial update on stereotactic radiosurgery for brain metastases in non-small cell lung cancer after a first-line third-generation EG…
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: Evolution of Hypofractionated Stereotactic Irradiation for Radio-Resistant Brain Metastases From D1-3-5 to D1-2-3 [Phase 3]
A Phase 3 trial update evaluating hypofractionated stereotactic irradiation for radio-resistant brain metastases, evolving from a D1-3-5 reg…
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: Observation or Upfront Cranial RT in Oncogene Mutated NSCLC With Asymptomatic BM: A Phase III RCT [Phase 3]
A Phase III randomized trial is evaluating upfront cranial radiotherapy versus observation in patients with oncogene-mutated non-small cell …
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CLINICAL_TRIALS research · 2025-09-09Clinical Trial Update: Combined Gamma Knife/Linac Radiosurgery for Large Brain Tumors / Metastases [Phase 2]
ClinicalTrials.gov entry describing a Phase 2 study evaluating combined Gamma Knife and Linac radiosurgery for large brain tumors and brain …
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CLINICAL_TRIALS research · 2025-09-08Clinical Trial Update: Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases [Phase 2]
Phase 2 trial assessing a triple combination of relatlimab, nivolumab, and ipilimumab in patients with asymptomatic and symptomatic melanoma…
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases [Phase 3]
Phase 3 trial evaluating pre-operative versus post-operative stereotactic radiosurgery for brain metastases; currently recruiting.