B-cell Acute Lymphoblastic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: CD22 CAR T-cells to Extend Remission Following Commercial CD19 CAR T-cells in Children, Adolescents, and Adults With Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 clinical trial evaluating CD22 CAR T-cells to extend remission after CD19 CAR T-cell therapy in children, adolescents, and adults wi…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: CD19-Car T Cell Therapy for the Treatment of Older Adults With Acute Lymphoblastic Leukemia in First Remission [Phase 1]
This clinical trial update describes a Phase 1 CD19-directed CAR-T cell therapy trial for older adults with acute lymphoblastic leukemia in …
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Induced Remission in Children and Young Adults With B Lineage Acute Lymphoblastic Leu... [NA]
This ClinicalTrials.gov entry describes a recruiting study evaluating next-generation sequencing for monitoring B-cell recovery to guide man…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: CAR-T Immunotherapy Targeting CD19- ALL [Phase 1, Phase 2]
This document updates a Phase 1/Phase 2 clinical trial of a CD19-targeted CAR-T cell therapy for B-cell acute lymphoblastic leukemia, sponso…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Clinical Study Evaluating the Safety and Efficacy of GT801 Injection in Adult Patients With Relapsed/Refractory CD19-positive B-cell Hematologic Malignancies and Autoimmune Hemolytic Anemia [EARLY_Phase 1]
A Phase 1 clinical trial evaluating the safety and efficacy of GT801 Injection in adults with relapsed/refractory CD19-positive B-cell hemat…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Study of Pedi-cRIB: Mini-Hyper-CVD With Condensed Rituximab, Inotuzumab Ozogamicin and Blinatumomab (cRIB) for Relapsed Therapy for Pediatric With B-Cell Lineage Acute Lymphocytic Leukemia [Phase 2]
Phase 2 study evaluating a condensed regimen (mini-Hyper-CVD with rituximab, inotuzumab ozogamicin, and blinatumomab) for relapsed pediatric…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell Cancers [Phase 1]
This document outlines an ongoing Phase 1 trial evaluating NKX019, an allogeneic CAR NK cell therapy, in adults with B-cell cancers includin…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: UCD19 CarT in Treatment of Pediatric B-ALL and B-NHL [Phase 1, Phase 2]
This clinical trial update notes the ongoing Phase 1/2 study of UCD19 CAR-T cell therapy in pediatric patients with B-cell acute lymphoblast…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL) [Phase 2]
Phase 2 clinical trial evaluating dasatinib or imatinib in combination with chemotherapy and blinatumomab for pediatric, adolescent, and you…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: Evaluation of the Safety and Efficacy of Sup19 CAR-T Cells in Patients With Previously Failed CD19-Targeted Therapy or CD19-Weakly Expressed Hematologic Tumors [Phase 1]
Phase 1 clinical trial evaluating the safety and efficacy of Sup19 CAR-T cells in patients with previously treated or CD19-weakly expressed …
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Study of Out of Specification for Tisagenlecleucel [Phase 3]
This document reports a Phase 3 clinical trial update for tisagenlecleucel (Kymriah) addressing an out-of-specification issue, for indicatio…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: A Study of Inotuzumab and Blinatumomab in People With B-cell Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
A clinical trial update describes a phase 1/2 study evaluating the combination of inotuzumab ozogamicin and blinatumomab in people with B-ce…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Study of Efficacy and Safety of Tisagenlecleucel in HR B-ALL EOC MRD Positive Patients [Phase 2]
Phase 2 clinical trial update evaluating the efficacy and safety of tisagenlecleucel in high-risk B-cell acute lymphoblastic leukemia patien…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Pomalidomide After CAR T-cell Therapy for the Treatment of Relapsed or Refractory CD19+ B-cell Leukemia or Lymphoma [Phase 1]
Phase 1 clinical trial update examining pomalidomide after CAR T-cell therapy for relapsed or refractory CD19+ B-cell leukemia or lymphoma.
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Phase 2 Study to Assess the Safety and Efficacy of Subcutaneous Blinatumomab in Patients With Measurable Residual Disease Positive B-cell Acute Lymphoblastic Leukemia [Phase 2]
This Phase 2 clinical trial update describes evaluating subcutaneous blinatumomab for safety and efficacy in patients with measurable residu…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Adaptive Dual-Target CAR-T Cells for Relapsed or Refractory Hematologic Malignancies [Phase 1, Phase 2]
Phase 1/Phase 2 clinical trial evaluating adaptive dual-target CAR-T cell therapy for relapsed or refractory hematologic malignancies; recru…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01) [Phase 1, Phase 2]
Substudy 01A of MK-9999-01A (LIGHTBEAM-U01) evaluates Zilovertamab Vedotin in pediatric and young adult participants with hematologic malign…
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CLINICAL_TRIALS other · 2026-04-08Clinical Trial Update: A Study of CD19 Targeted CAR T Cell Therapy in Adult Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL) [Phase 1, Phase 2]
An ongoing Phase 1/Phase 2 clinical trial of a CD19-targeted CAR T cell therapy for relapsed or refractory B-cell acute lymphoblastic leukem…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin (DA-EPOCH) With or Without Rituximab Plus Recombinant Erwinia Asparaginase (JZP458) for the Treatment of Newly Diagnosed Ph Negative B-Acute Lymphoblastic Leukemia or T Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 clinical trial evaluating DA-EPOCH chemotherapy with or without Rituximab plus recombinant Erwinia asparaginase (JZP458) for newly d…
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CLINICAL_TRIALS trial_result · 2026-04-07Clinical Trial Update: Ibrutinib and Blinatumomab in Treating Patients With Relapsed or Refractory B Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 study evaluating the combination of ibrutinib and blinatumomab for relapsed or refractory B-cell acute lymphoblastic leukemia, inclu…
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CLINICAL_TRIALS trial_result · 2026-04-07Clinical Trial Update: Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia [Phase 3]
A Phase 3 trial of inotuzumab ozogamicin with frontline chemotherapy for newly diagnosed B-cell acute lymphoblastic leukemia in young adults…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Testing the Combination of Inotuzumab Ozogamicin and Lower Dose Chemotherapy Compared to Usual Chemotherapy for Adults With B-Cell Acute Lymphoblastic Leukemia or B-Cell Lymphoblastic Lymphoma [Phase 2]
Phase 2 trial update evaluating the combination of Inotuzumab ozogamicin with lower-dose chemotherapy versus standard chemotherapy in adults…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
AstraZeneca is conducting Phase 1/2 studies of AZD4512 as monotherapy or in combination with other anticancer agents in participants with B-…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: U96-CAR-T-Cells For R/R B-ALL [Phase 1]
This clinical trial update reports a Phase 1 study of U96-CAR-T-Cells for relapsed or refractory B-cell acute lymphoblastic leukemia and B-c…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: CLIC-2201 for the Treatment of Relapsed/Refractory B Cell Malignancies [Phase 1]
A Phase 1 study of CLIC-2201 for relapsed/refractory B-cell malignancies is currently recruiting. The conditions covered include various B-c…