B-cell Acute Lymphoblastic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: CD19-Car T Cell Therapy for the Treatment of Older Adults With Acute Lymphoblastic Leukemia in First Remission [Phase 1]
This clinical trial update describes a Phase 1 CD19-directed CAR-T cell therapy trial for older adults with acute lymphoblastic leukemia in …
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Induced Remission in Children and Young Adults With B Lineage Acute Lymphoblastic Leu... [NA]
This ClinicalTrials.gov entry describes a recruiting study evaluating next-generation sequencing for monitoring B-cell recovery to guide man…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: CAR-T Immunotherapy Targeting CD19- ALL [Phase 1, Phase 2]
This document updates a Phase 1/Phase 2 clinical trial of a CD19-targeted CAR-T cell therapy for B-cell acute lymphoblastic leukemia, sponso…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Clinical Study Evaluating the Safety and Efficacy of GT801 Injection in Adult Patients With Relapsed/Refractory CD19-positive B-cell Hematologic Malignancies and Autoimmune Hemolytic Anemia [EARLY_Phase 1]
A Phase 1 clinical trial evaluating the safety and efficacy of GT801 Injection in adults with relapsed/refractory CD19-positive B-cell hemat…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Study of Pedi-cRIB: Mini-Hyper-CVD With Condensed Rituximab, Inotuzumab Ozogamicin and Blinatumomab (cRIB) for Relapsed Therapy for Pediatric With B-Cell Lineage Acute Lymphocytic Leukemia [Phase 2]
Phase 2 study evaluating a condensed regimen (mini-Hyper-CVD with rituximab, inotuzumab ozogamicin, and blinatumomab) for relapsed pediatric…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell Cancers [Phase 1]
This document outlines an ongoing Phase 1 trial evaluating NKX019, an allogeneic CAR NK cell therapy, in adults with B-cell cancers includin…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: UCD19 CarT in Treatment of Pediatric B-ALL and B-NHL [Phase 1, Phase 2]
This clinical trial update notes the ongoing Phase 1/2 study of UCD19 CAR-T cell therapy in pediatric patients with B-cell acute lymphoblast…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL) [Phase 2]
Phase 2 clinical trial evaluating dasatinib or imatinib in combination with chemotherapy and blinatumomab for pediatric, adolescent, and you…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Study of Out of Specification for Tisagenlecleucel [Phase 3]
This document reports a Phase 3 clinical trial update for tisagenlecleucel (Kymriah) addressing an out-of-specification issue, for indicatio…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Study of Efficacy and Safety of Tisagenlecleucel in HR B-ALL EOC MRD Positive Patients [Phase 2]
Phase 2 clinical trial update evaluating the efficacy and safety of tisagenlecleucel in high-risk B-cell acute lymphoblastic leukemia patien…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Pomalidomide After CAR T-cell Therapy for the Treatment of Relapsed or Refractory CD19+ B-cell Leukemia or Lymphoma [Phase 1]
Phase 1 clinical trial update examining pomalidomide after CAR T-cell therapy for relapsed or refractory CD19+ B-cell leukemia or lymphoma.
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Phase 2 Study to Assess the Safety and Efficacy of Subcutaneous Blinatumomab in Patients With Measurable Residual Disease Positive B-cell Acute Lymphoblastic Leukemia [Phase 2]
This Phase 2 clinical trial update describes evaluating subcutaneous blinatumomab for safety and efficacy in patients with measurable residu…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Adaptive Dual-Target CAR-T Cells for Relapsed or Refractory Hematologic Malignancies [Phase 1, Phase 2]
Phase 1/Phase 2 clinical trial evaluating adaptive dual-target CAR-T cell therapy for relapsed or refractory hematologic malignancies; recru…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin (DA-EPOCH) With or Without Rituximab Plus Recombinant Erwinia Asparaginase (JZP458) for the Treatment of Newly Diagnosed Ph Negative B-Acute Lymphoblastic Leukemia or T Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 clinical trial evaluating DA-EPOCH chemotherapy with or without Rituximab plus recombinant Erwinia asparaginase (JZP458) for newly d…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Testing the Combination of Inotuzumab Ozogamicin and Lower Dose Chemotherapy Compared to Usual Chemotherapy for Adults With B-Cell Acute Lymphoblastic Leukemia or B-Cell Lymphoblastic Lymphoma [Phase 2]
Phase 2 trial update evaluating the combination of Inotuzumab ozogamicin with lower-dose chemotherapy versus standard chemotherapy in adults…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
AstraZeneca is conducting Phase 1/2 studies of AZD4512 as monotherapy or in combination with other anticancer agents in participants with B-…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: U96-CAR-T-Cells For R/R B-ALL [Phase 1]
This clinical trial update reports a Phase 1 study of U96-CAR-T-Cells for relapsed or refractory B-cell acute lymphoblastic leukemia and B-c…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: CLIC-2201 for the Treatment of Relapsed/Refractory B Cell Malignancies [Phase 1]
A Phase 1 study of CLIC-2201 for relapsed/refractory B-cell malignancies is currently recruiting. The conditions covered include various B-c…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Study of KTE-X19 in Minimal Residual Disease (MRD) Positive B-Cell Acute Lymphoblastic Leukemia (B-ALL) [Phase 2]
Phase 2 clinical trial update for KTE-X19 in minimal residual disease–positive B-cell acute lymphoblastic leukemia, currently recruiting.
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19) [Phase 1, Phase 2]
A Phase 1/2 clinical trial of SENTRY-CD19, a CD19-targeted gene therapy, in multiple CD19-positive hematologic malignancies is currently rec…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: NexCAR19 (Talikabtagene Autoleucel) in Relapsed/Refractory B-Cell Malignancies (NexCAR19) [Phase 2, Phase 3]
Clinical trial update for NexCAR19 (Talikabtagene autoleucel), a CAR-T therapy studied in relapsed/refractory B-cell malignancies; the Phase…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Study of Fludarabine Dosing in Children and Young Adults With B-cell Acute Lymphoblastic Leukemia [Phase 3]
A Phase 3 clinical trial evaluating different fludarabine dosing regimens in children and young adults with B-cell acute lymphoblastic leuke…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Co-administration of CART22-65s and huCART19 for B-ALL [Phase 1, Phase 2]
This document reports a Phase 1/2 clinical trial update on co-administering CART22-65s and huCART19 for B-cell acute lymphoblastic leukemia …
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Immunotherapy Combined With Auto-HSCT and CD22/CD19 CAR-T Sandwich Strategy for B-ALL [Phase 2]
Phase 2 clinical trial evaluating a combination of immunotherapy with autologous hematopoietic stem cell transplant and CD22/CD19 CAR-T cell…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Clinical Study of Universal CD19 CAR-γδ T Cell Infusion in the Treatment of Relapsed/Refractory Acute B Lymphoblastic Leukemia [Phase 1]
Phase 1 clinical study evaluating universal CD19 CAR-γδ T cell infusion for relapsed/refractory acute lymphoblastic leukemia (B-cell lineage…