Anaplastic Astrocytoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2020-03-03Clinical Trial Update: Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma [Phase 1, Phase 2]
Phase 1/2 trial evaluating Vorinostat with radiation followed by maintenance therapy in younger patients with newly diagnosed diffuse intrin…
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CLINICAL_TRIALS trial_result · 2020-02-07Clinical Trial Update: The Toca 5 Trial: Toca 511 & Toca FC Versus Standard of Care in Patients With Recurrent High Grade Glioma [Phase 2, Phase 3]
Clinical trial update for Toca 511 & Toca FC in recurrent high-grade glioma (Phase 2/3) has been terminated.
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CLINICAL_TRIALS trial_result · 2020-01-02Clinical Trial Update: Viral Therapy in Treating Patients With Recurrent Glioblastoma Multiforme [Phase 1]
Phase 1 trial update for a viral therapy in recurrent glioblastoma multiforme with related glioma conditions; results posted.
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FDA approval · 2019-11-22FDA Approved: TEMODAR — Supplemental Application (Merck Sharp & Dohme LLC)
The FDA approved a supplemental application for TEMODAR (temozolomide) submitted by Merck Sharp & Dohme LLC.
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CLINICAL_TRIALS trial_result · 2019-09-09Clinical Trial Update: Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas [Phase 1]
Phase 1 trial evaluating alisertib in combination with fractionated stereotactic radiosurgery for adults with recurrent high-grade gliomas h…
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FDA approval · 2019-07-16FDA Approved: TEMOZOLOMIDE — Supplemental Application (Amneal Pharmaceuticals LLC)
The FDA approved Amneal Pharmaceuticals LLC's supplemental application for temozolomide, a generic version of Temodar, under ANDA 203691.
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CLINICAL_TRIALS trial_result · 2018-08-16Clinical Trial Update: Efficacy of Two Temozolomide Regimens in Adjuvant Treatment of Patients With Brain High Grade Glioma [Phase 3]
A Phase 3 clinical trial comparing two temozolomide regimens for adjuvant treatment in high-grade glioma of the brain, including glioblastom…
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CLINICAL_TRIALS trial_result · 2018-07-20Clinical Trial Update: Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors [Phase 2]
A Phase 2 trial evaluating imetelstat in younger patients with recurrent or refractory brain tumors was terminated, with results posted in J…
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CLINICAL_TRIALS withdrawal · 2018-07-20Clinical Trial Update: Fluorescein vs. iMRI in Resection of Malignant High Grade Glioma [NA]
The clinical trial NCT02540135 evaluating fluorescein-guided resection with intraoperative MRI for malignant high-grade gliomas has been wit…
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CLINICAL_TRIALS trial_result · 2018-07-09Clinical Trial Update: Pharmacokinetics in Patients With Newly Diagnosed High-Grade Glioma Receiving Temozolomide and Radiation Therapy
This clinical trial update reports pharmacokinetic data from a study of temozolomide with radiation therapy in patients with newly diagnosed…
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CLINICAL_TRIALS trial_result · 2018-07-05Clinical Trial Update: (11C)dLop as a Marker of P-Glycoprotein Function in Patients With Gliomas
A clinical trial evaluating the PET tracer 11C-dLop as a marker of P-glycoprotein function in gliomas was terminated. The study enrolled pat…
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CLINICAL_TRIALS trial_result · 2018-07-03Clinical Trial Update: Yoga Therapy in Treating Patients With Malignant Brain Tumors [NA]
This entry notes a terminated clinical trial at Wake Forest evaluating yoga therapy for adults with malignant brain tumors.
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CLINICAL_TRIALS trial_result · 2018-07-02Clinical Trial Update: Carboplatin in Treating Patients With Recurrent High-Grade Gliomas [Phase 1]
Phase 1 results from a carboplatin trial in patients with recurrent high-grade gliomas, including adults with anaplastic astrocytoma and ana…
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CLINICAL_TRIALS trial_result · 2018-05-21Clinical Trial Update: Study of a Retroviral Replicating Vector Combined With a Prodrug to Treat Patients Undergoing Surgery for a Recurrent Malignant Brain Tumor [Phase 1]
Phase 1 study evaluating Tocagen's retroviral replicating vector Toca 511 in combination with the prodrug 5-fluorocytosine for recurrent mal…
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CLINICAL_TRIALS trial_result · 2018-05-21Clinical Trial Update: Study of a Retroviral Replicating Vector Given Intravenously to Patients Undergoing Surgery for Recurrent Brain Tumor [Phase 1]
This document reports the completion of a Phase 1 trial evaluating a retroviral replicating vector (Toca 511) given intravenously to patient…
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CLINICAL_TRIALS trial_result · 2018-05-21Clinical Trial Update: A Study of a Retroviral Replicating Vector Combined With a Prodrug Administered to Patients With Recurrent Malignant Glioma [Phase 1]
Phase 1 study evaluating the safety and feasibility of Toca 511, a retroviral replicating vector, in combination with the prodrug Toca FC in…
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CLINICAL_TRIALS trial_result · 2018-05-15Clinical Trial Update: Immunotoxin Therapy in Treating Children With Progressive or Recurrent Glioblastoma Multiforme or Anaplastic Astrocytoma [Phase 1]
Phase 1 clinical trial evaluating an immunotoxin therapy in children with progressive or recurrent glioblastoma multiforme or anaplastic ast…
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CLINICAL_TRIALS trial_result · 2018-04-17Clinical Trial Update: Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases [Phase 1]
This Phase 1 trial assessing bafetinib in adults with recurrent high-grade glioma or brain metastases has completed.
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CLINICAL_TRIALS trial_result · 2018-02-23Clinical Trial Update: A Study on β-elemene as Maintain Treatment for Newly Diagnosed Malignant Gliomas [Phase 3]
Phase 3 trial update on β-elemene as maintenance therapy for newly diagnosed malignant gliomas is ongoing, status currently unknown.
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CLINICAL_TRIALS trial_result · 2018-02-23Clinical Trial Update: Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma [Phase 1]
A Phase 1 trial evaluating temozolomide with ascorbic acid in recurrent high-grade glioma was terminated; results posted in 2018.
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CLINICAL_TRIALS trial_result · 2018-02-23Clinical Trial Update: A Phase III Trial on Adjuvant Temozolomide With or Without Interferon-alpha in Newly Diagnosed High-grade Gliomas [Phase 3]
Phase III trial investigating adjuvant temozolomide with or without interferon-alpha in newly diagnosed high-grade gliomas, including anapla…
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CLINICAL_TRIALS research · 2017-12-13Clinical Trial Update: FET-PET and Multiparametric MRI for High-grade Glioma Patients Undergoing Radiotherapy
A clinical trial update from University Hospital, Brest describes evaluating FET-PET imaging and multiparametric MRI to guide radiotherapy i…
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CLINICAL_TRIALS trial_result · 2017-12-02Clinical Trial Update: Vaccination With Dendritic Cells Loaded With Brain Tumor Stem Cells for Progressive Malignant Brain Tumor [Phase 1]
Phase 1 trial evaluating autologous dendritic cells loaded with brain tumor stem cells for progressive malignant brain tumors has completed.
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CLINICAL_TRIALS trial_result · 2017-11-17Clinical Trial Update: Plerixafor (AMD3100) and Bevacizumab for Recurrent High-Grade Glioma [Phase 1]
Phase 1 trial evaluating the combination of plerixafor (AMD3100) and bevacizumab for recurrent high-grade glioma has been terminated. The st…
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CLINICAL_TRIALS trial_result · 2017-11-13Clinical Trial Update: Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas [Phase 3]
Phase 3 trial evaluating radiation therapy combined with chemotherapy in anaplastic astrocytoma or mixed gliomas has completed with results …