Anaplastic Astrocytoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors
This trial update describes a pediatric brain tumor study using cerebrospinal fluid cell-free tumor DNA; the study was terminated.
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant [Phase 2]
Phase 2 clinical trial exploring ribociclib with everolimus or with temozolomide for high-grade gliomas and related diffuse gliomas; recruit…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma [Phase 1]
This clinical trial investigates temozolomide (Temodar) in combination with the HDAC inhibitor Abexinostat for recurrent high-grade gliomas,…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma [Phase 2]
A Phase 2 clinical trial update examining the combination of dabrafenib and trametinib after radiation therapy for newly diagnosed high-grad…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA [Phase 2]
Phase 2 clinical trial investigating super selective intra-arterial cetuximab with reirradiation for relapsed or refractory glioblastoma, an…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma [Phase 1]
A Phase 1 pediatric trial of SurVaxM for progressive or relapsed medulloblastoma, high-grade glioma, ependymoma, and newly diagnosed diffuse…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Targeted Pediatric High-Grade Glioma Therapy
A pediatric clinical trial is currently recruiting to evaluate a targeted therapy for high-grade gliomas, including diffuse intrinsic pontin…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM [Phase 1, Phase 2]
A Phase 1/2 clinical trial update evaluating HSV-tk gene therapy with valacyclovir and SBRT plus chemotherapy for recurrent glioblastoma and…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating HSV-tk gene therapy in combination with radiotherapy and chemotherapy for newly diagnosed glioblastoma…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion [EARLY_Phase 1]
A Phase 1 study assessing lorlatinib for newly diagnosed high-grade gliomas with ALK or ROS1 fusions; currently recruiting.
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma [Phase 1]
Phase 1 trial evaluating mesenchymal stem cell-delivered DNX-2401 for recurrent high-grade glioma. The study is currently recruiting.
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: Intensity-Modulated Stereotactic Radiation Therapy in Treating Patients With Grade II-IV Glioma [NA]
Ongoing clinical trial evaluating intensity-modulated stereotactic radiotherapy for patients with grade II–IV gliomas, including glioblastom…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: Study of Pembrolizumab and M032 (NSC 733972) [Phase 1, Phase 2]
A Phase 1/2 clinical trial update evaluating pembrolizumab in combination with M032 for glioblastoma, anaplastic astrocytoma, and gliosarcom…
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma [Phase 2]
Phase 2 clinical trial evaluating Gallium-68 PSMA-11 PET/CT for detecting recurrence or progression in high-grade gliomas (WHO Grade 3 and G…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Peds CHAMP1ON - Hematopoietic Stem Cell And Monoclonal Antibody PD-1 Blockade for RecurreNt Pediatric High-Grade Glioma [Phase 1]
A Phase 1 clinical trial in pediatric patients with recurrent high-grade glioma evaluating hematopoietic stem cell therapy in combination wi…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms [Phase 1]
Phase I trial update indicates ONC206 is being studied for recurrent and rare primary central nervous system neoplasms and the study is curr…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age [Phase 1, Phase 2]
A Phase 1/2 clinical trial update for relapsed/refractory intracranial glioma in patients under 22 years, currently recruiting.
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent Malignant Glioma [Phase 1]
This is a Phase Ib dose-escalation trial evaluating intratumoral administration of IRS-1 HSV C134 in patients with recurrent malignant gliom…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Implantable Microdevice In Primary Brain Tumors [EARLY_Phase 1]
An early Phase 1 clinical trial evaluating an implantable microdevice for primary brain tumors is currently recruiting across multiple gliom…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Fimepinostat in Treating Brain Tumors in Children and Young Adults [EARLY_Phase 1]
This is an early-phase 1 trial update on fimepinostat for pediatric and young adult brain tumors, including DIPG, recurrent anaplastic astro…
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CLINICAL_TRIALS research · 2025-07-09Clinical Trial Update: Loupe-Based Intraoperative Fluorescence Imaging
Clinical trial update on loupe-based intraoperative fluorescence imaging for brain tumors; recruitment is ongoing for glioblastoma and anapl…
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CLINICAL_TRIALS research · 2025-07-03Clinical Trial Update: Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma [NA]
This Columbia University trial assesses adaptive radiotherapy guided by MRI for adults with newly diagnosed high-grade glioma, including gli…
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CLINICAL_TRIALS research · 2025-05-29Clinical Trial Update: DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma [Phase 2]
This entry describes a Phase 2 trial evaluating DB107-Retroviral Replicating Vector (RRV) in combination with DB107-Flucytosine for recurren…
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CLINICAL_TRIALS research · 2025-05-16Clinical Trial Update: Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) in Glioma (WHO G3-G4) Progression [NA]
This entry notes that recruitment is ongoing for a local alpha-emitter therapy, [225Ac]Ac-DOTA-SP (TAT), being studied for glioblastoma and …
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating repeated super-selective intraarterial infusion of bevacizumab (Avastin) for relapsed glioblastoma …