Anaplastic Astrocytoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2024-07-05Clinical Trial Update: A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas [Phase 1, Phase 2]
A Phase I/Phase II study evaluating mebendazole for pediatric gliomas has completed. It enrolled children with various glial tumors, includi…
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CLINICAL_TRIALS trial_result · 2024-07-05Clinical Trial Update: CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma [Phase 1]
Phase 1 study of CC-90010 assesses CNS penetration, pharmacokinetics, and pharmacodynamics in progressive/recurrent diffuse astrocytoma, ana…
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CLINICAL_TRIALS trial_result · 2024-05-31Clinical Trial Update: SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors [Phase 1]
The SJDAWN Phase 1 trial at St. Jude evaluated molecularly-driven doublet therapies for children and young adults with recurrent brain tumor…
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CLINICAL_TRIALS trial_result · 2024-04-29Clinical Trial Update: Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas [Phase 1]
Phase 1 clinical trial update evaluating safety and preliminary efficacy of carboxylesterase-expressing allogeneic neural stem cells in comb…
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CLINICAL_TRIALS trial_result · 2024-04-23Clinical Trial Update: Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations [Phase 2]
Phase 2 clinical trial evaluating veliparib in combination with radiation therapy and temozolomide for newly diagnosed malignant glioma; res…
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CLINICAL_TRIALS trial_result · 2024-04-08Clinical Trial Update: Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children [Phase 1]
Phase 1b trial update for PVSRIPO in recurrent malignant glioma in children has completed enrollment and results posted.
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CLINICAL_TRIALS trial_result · 2024-04-03Clinical Trial Update: Phase 2a Study of CAN-2409 With Standard Radiation Therapy for Malignant Glioma [Phase 2]
Phase 2a study of CAN-2409 with standard radiation therapy in malignant glioma (including glioblastoma multiforme) has completed; results po…
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CLINICAL_TRIALS trial_result · 2024-03-06Clinical Trial Update: Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG [Phase 2]
A Phase 2 study of the MEK inhibitor binimetinib plus the BRAF inhibitor encorafenib in adults with recurrent BRAF V600-mutant high-grade gl…
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CLINICAL_TRIALS trial_result · 2024-02-02Clinical Trial Update: Genetically Engineered HSV-1 Phase 1 Study for the Treatment of Recurrent Malignant Glioma [Phase 1]
This entry describes a Phase 1 clinical trial of a genetically engineered HSV-1 therapy for recurrent malignant glioma, including glioblasto…
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CLINICAL_TRIALS trial_result · 2024-01-03Clinical Trial Update: Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas [Phase 1]
Phase 1 trial evaluating adavosertib with local radiation in children with newly diagnosed diffuse intrinsic pontine glioma; results are pos…
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CLINICAL_TRIALS trial_result · 2023-05-22Clinical Trial Update: Phase I/II Trial of AXL1717 in the Treatment of Recurrent Malignant Astrocytomas [Phase 1, Phase 2]
Phase I/II trial of AXL1717 in recurrent malignant astrocytomas (glioblastoma, gliosarcoma) with terminated status and results posted.
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CLINICAL_TRIALS trial_result · 2023-01-20Clinical Trial Update: Neural Stem Cell Based Virotherapy of Newly Diagnosed Malignant Glioma [Phase 1]
Phase 1 trial update of neural stem cell–based virotherapy for newly diagnosed malignant glioma; study completed with results posted in 2023…
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CLINICAL_TRIALS trial_result · 2022-08-15Clinical Trial Update: Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children [Phase 2]
Phase 2 pilot study of cabozantinib for recurrent or progressive central nervous system tumors in children has been terminated; results were…
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CLINICAL_TRIALS trial_result · 2022-08-10Clinical Trial Update: Laser Interstitial Thermal Therapy and Lomustine in Treating Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma [Phase 2]
Phase 2 trial exploring laser interstitial thermal therapy with lomustine in recurrent glioblastoma or anaplastic astrocytoma; the study is …
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CLINICAL_TRIALS trial_result · 2022-08-09Clinical Trial Update: Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 [Phase 1, Phase 2]
Phase 1/2 trial evaluating intraarterial cetuximab (Erbitux) and bevacizumab for relapsed/refractory intracranial glioma in patients under 2…
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FDA approval · 2022-08-03FDA Approved: TEMOZOLOMIDE — Supplemental Application (Accord Healthcare Inc.)
FDA approves a supplemental application for Temozolomide from Accord Healthcare Inc., a generic cancer drug.
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CLINICAL_TRIALS trial_result · 2022-01-21Clinical Trial Update: Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients [Phase 3]
Phase 3 trial comparing eflornithine plus lomustine versus lomustine alone in recurrent anaplastic astrocytoma patients; current status unkn…
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FDA approval · 2021-11-23FDA Approved: TEMOZOLOMIDE — Original Application (Nivagen Pharmaceuticals, Inc.)
FDA approved temozolomide from Nivagen Pharmaceuticals under an original application for the treatment of malignant gliomas, including gliob…
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CLINICAL_TRIALS trial_result · 2021-09-29Clinical Trial Update: Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas [Phase 1]
Phase 1 trial evaluating genetically modified neural stem cells with flucytosine and leucovorin for recurrent high-grade gliomas; results co…
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CLINICAL_TRIALS trial_result · 2021-09-28Clinical Trial Update: Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma [Phase 1, Phase 2]
This ClinicalTrials.gov update reports a terminated Phase 1/2 study evaluating Zotiraciclib (TG02) in combination with dose-dense or metrono…
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CLINICAL_TRIALS trial_result · 2021-07-21Clinical Trial Update: Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma [Phase 2]
Phase 2 trial evaluating valproic acid with radiation and bevacizumab in pediatric high-grade gliomas and diffuse intrinsic pontine glioma h…
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FDA approval · 2020-11-20FDA Approved: TEMODAR — Supplemental Application (Merck Sharp & Dohme LLC)
The FDA approved a supplemental application for Temodar (temozolomide) filed by Merck Sharp & Dohme LLC, resulting in updated labeling to re…
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FDA approval · 2020-08-13FDA Approved: TEMOZOLOMIDE — Supplemental Application (Accord Healthcare Inc.)
FDA approves Accord Healthcare Inc.'s supplemental application for temozolomide, supporting a generic version of the drug. The action corres…
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CLINICAL_TRIALS withdrawal · 2020-03-24Clinical Trial Update: Testing the Addition of an Anti-cancer Viral Gene Therapy, Toca 511/Toca FC, to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed Glioblastoma [Phase 2, Phase 3]
Clinical trial evaluating Toca 511/Toca FC added to standard therapy for newly diagnosed glioblastoma has been withdrawn.
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CLINICAL_TRIALS trial_result · 2020-03-12Clinical Trial Update: Efficacy of Hypofractionated XRT w/Bev. + Temozolomide for Recurrent Gliomas [Phase 2]
Phase 2 trial evaluating hypofractionated external radiotherapy with bevacizumab and temozolomide for recurrent gliomas; the study was termi…