Anaplastic Astrocytoma
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Sign up freeTop drugs studied for this disease
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EMA approval · 2025-11-06EMA Authorised: Temodal (temozolomide) — Merck Sharp & Dohme B.V.
The EMA authorised Temodal (temozolomide) for glioma, with Merck Sharp & Dohme B.V. as the marketing authorisation holder; decision date 06/…
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FDA approval · 2025-10-27FDA Approved: LOMUSTINE — Original Application (Carnegie Pharmaceuticals LLC)
FDA approves Carnegie Pharmaceuticals LLC's original application for lomustine (LOMUSTINE), making a generic version of the chemotherapy dru…
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CLINICAL_TRIALS trial_result · 2025-09-15Clinical Trial Update: Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas
The clinical trial investigating microRNA-10b expression in glioma patients has been terminated.
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CLINICAL_TRIALS trial_result · 2025-09-02Clinical Trial Update: Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surgery and Radiation Therapy in Treating Patients With Newly Diagnosed High- or Low-Grade Malignant Glioma [EARLY_Phase 1]
Early-phase study evaluating the use of 18F-FDOPA PET imaging to plan surgery and radiation therapy for adults with newly diagnosed malignan…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent Malignant Glioma [Phase 1]
This is a Phase Ib dose-escalation trial evaluating intratumoral administration of IRS-1 HSV C134 in patients with recurrent malignant gliom…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Implantable Microdevice In Primary Brain Tumors [EARLY_Phase 1]
An early Phase 1 clinical trial evaluating an implantable microdevice for primary brain tumors is currently recruiting across multiple gliom…
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CLINICAL_TRIALS trial_result · 2025-07-16Clinical Trial Update: Study Of NOVOTTF-200A In Bevacizumab-Naive Subjects With Recurrent Grade III Malignant Astrocytoma [NA]
Results posted for a study of NOVOTTF-200A in bevacizumab-naive subjects with recurrent grade III malignant astrocytoma.
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Fimepinostat in Treating Brain Tumors in Children and Young Adults [EARLY_Phase 1]
This is an early-phase 1 trial update on fimepinostat for pediatric and young adult brain tumors, including DIPG, recurrent anaplastic astro…
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CLINICAL_TRIALS trial_result · 2025-07-11Clinical Trial Update: Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma [Phase 2]
Phase 2 trial comparing proton beam therapy with intensity-modulated radiation therapy for preserving brain function in IDH-mutant grade II/…
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CLINICAL_TRIALS research · 2025-07-09Clinical Trial Update: Loupe-Based Intraoperative Fluorescence Imaging
Clinical trial update on loupe-based intraoperative fluorescence imaging for brain tumors; recruitment is ongoing for glioblastoma and anapl…
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CLINICAL_TRIALS trial_result · 2025-07-03Clinical Trial Update: Trial of C134 in Patients With Recurrent GBM [Phase 1]
Phase 1 clinical trial update for C134 in recurrent glioblastoma and related brain cancers reports results with results posted on 2025-07-03…
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CLINICAL_TRIALS research · 2025-07-03Clinical Trial Update: Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma [NA]
This Columbia University trial assesses adaptive radiotherapy guided by MRI for adults with newly diagnosed high-grade glioma, including gli…
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CLINICAL_TRIALS research · 2025-05-29Clinical Trial Update: DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma [Phase 2]
This entry describes a Phase 2 trial evaluating DB107-Retroviral Replicating Vector (RRV) in combination with DB107-Flucytosine for recurren…
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CLINICAL_TRIALS research · 2025-05-16Clinical Trial Update: Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) in Glioma (WHO G3-G4) Progression [NA]
This entry notes that recruitment is ongoing for a local alpha-emitter therapy, [225Ac]Ac-DOTA-SP (TAT), being studied for glioblastoma and …
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CLINICAL_TRIALS trial_result · 2025-04-09Clinical Trial Update: Repeated Super-selective Intraarterial Cerebral Infusion Of Bevacizumab Plus Carboplatin For Treatment Of Relapsed/Refractory GBM And Anaplastic Astrocytoma [Phase 1, Phase 2]
A Phase 1/2 trial of repeated super-selective intraarterial bevacizumab plus carboplatin for relapsed/refractory glioblastoma multiforme and…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating repeated super-selective intraarterial infusion of bevacizumab (Avastin) for relapsed glioblastoma …
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CLINICAL_TRIALS trial_result · 2025-02-21Clinical Trial Update: Studying the Safety, Efficacy, and Pharmacokinetic Characteristics of BNCT in Patients With Recurrent High-grade Gliomas [Phase 1, Phase 2]
A terminated Phase 1/2 trial evaluated the safety, efficacy, and pharmacokinetics of boron neutron capture therapy (BNCT) for recurrent high…
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CLINICAL_TRIALS trial_result · 2025-02-19Clinical Trial Update: INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas [Phase 1]
Phase 1 trial of INCB7839 in children with recurrent or progressive high-grade gliomas has completed and results have been posted.
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CLINICAL_TRIALS research · 2025-02-18Clinical Trial Update: Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine [Phase 1]
A Phase 1 trial of the Heat Shock Protein Peptide Complex-96 (HSPPC-96) vaccine for glioblastoma and related CNS tumors was terminated. The …
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CLINICAL_TRIALS research · 2025-02-11Clinical Trial Update: Safety and Efficacy Study for DC Vaccine in Recurrent or Progressive High-grade Gliomas [Phase 1]
Phase 1 safety and efficacy study of a dendritic cell (DC) vaccine for recurrent or progressive high-grade gliomas (WHO grade III and IV) in…
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CLINICAL_TRIALS trial_result · 2024-11-06Clinical Trial Update: Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma [Phase 1]
A Phase 1 trial evaluating Lapatinib Ditosylate before surgical resection in adults with recurrent high-grade glioma has completed. The stud…
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CLINICAL_TRIALS trial_result · 2024-08-28Clinical Trial Update: Dendritic Cell Vaccine for Patients With Brain Tumors [Phase 2]
Phase 2 trial of an autologous dendritic cell vaccine for brain tumors has completed enrollment and assessment.
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FDA approval · 2024-08-23FDA Approved: TEMOZOLOMIDE — Supplemental Application (CivicaScript LLC)
FDA approved CivicaScript LLC's supplemental application for temozolomide, a generic version of the chemotherapy drug Temozolomide (ANDA 207…
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FDA approval · 2024-08-23FDA Approved: TEMOZOLOMIDE — Original Application (Camber Pharmaceuticals, Inc.)
FDA approved Camber Pharmaceuticals' generic temozolomide through an original application for the treatment of malignant gliomas, including …
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CLINICAL_TRIALS trial_result · 2024-08-09Clinical Trial Update: Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors [Phase 2]
Phase 2 pediatric brain tumor trial evaluating MRI-guided laser heat ablation to disrupt the peritumoral blood-brain barrier in order to imp…