Amyotrophic Lateral Sclerosis
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CLINICAL_TRIALS trial_result · 2026-01-30Clinical Trial Update: New Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis [NA]
Completed study investigating new MRI biomarkers for amyotrophic lateral sclerosis. The findings suggest potential imaging indicators for di…
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CLINICAL_TRIALS trial_result · 2026-01-29Clinical Trial Update: Respiratory Muscle Training (RMT) in ALS [NA]
The clinical trial evaluating Respiratory Muscle Training (RMT) in amyotrophic lateral sclerosis has completed and posted results.
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CLINICAL_TRIALS trial_result · 2026-01-28Clinical Trial Update: HEALEY ALS Platform Trial - Regimen G DNL343 [Phase 2, Phase 3]
Results from the HEALEY ALS Platform Trial Regimen G evaluating DNL343 in amyotrophic lateral sclerosis have been posted after completion of…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Healing ALS Registry Observational Study (HAROS)
HAROS is an ongoing observational registry for amyotrophic lateral sclerosis and related motor neuron diseases. Recruitment is currently ope…
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: A Clinical Trial to Evaluate NB-4746 in Participants With Amyotrophic Lateral Sclerosis. [Phase 1, Phase 2]
This document reports an early-stage clinical trial evaluating NB-4746 for amyotrophic lateral sclerosis, which is not yet recruiting.
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: Initiation of Noninvasive Ventilation in ALS Patients With Chronic Respiratory Insufficiency [NA]
A clinical trial (NCT06286917) has initiated to evaluate noninvasive ventilation in ALS patients with chronic respiratory insufficiency; spo…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: UPenn Observational Research Repository on Neurodegenerative Disease
The University of Pennsylvania is conducting an observational research repository for neurodegenerative diseases and is currently recruiting…
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Interest of Measuring P2X4 Receptors on Blood Monocytes as a Diagnostic Marker in Amyotrophic Lateral Sclerosis: P2X4 as a Diagnostic Biomarker for ALS [NA]
This ongoing clinical trial investigates whether measuring P2X4 receptor expression on blood monocytes can diagnose amyotrophic lateral scle…
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: The Importance of Positive Expiratory Pressure Associated With the In-exsufflator in ALS Patients [NA]
A clinical trial evaluating the use of positive expiratory pressure with an in-exsufflator in patients with amyotrophic lateral sclerosis; c…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Chinese Participants With SOD-1 Amyotrophic Lateral Sclerosis (ALS) [Phase 4]
This clinical trial update describes a Phase 4 study to assess the long-term safety of Tofersen (Qalsody) in Chinese participants with SOD-1…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study [NA]
Update on the Controlling ALS Motor Neuron Excitability Study shows that the trial is currently recruiting for amyotrophic lateral sclerosis…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Control Cohort CTRL COH [NA]
A status update for a control cohort in a Hospices Civils de Lyon trial, with recruitment ongoing for Parkinson's disease, amyotrophic later…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: A Physiotherapy Intervention Study in Patients With Amyotrophic Lateral Sclerosis (ALS) [NA]
Clinical trial update for a physiotherapy intervention study in patients with Amyotrophic Lateral Sclerosis, currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: Atalante Exoskeleton in the Rehabilitation of Patients With Amyotrophic Lateral Sclerosis [NA]
A clinical trial update indicates the Atalante Exoskeleton study for rehabilitation in amyotrophic lateral sclerosis has been suspended.
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: Spinal Interneuron Excitability in ALS [NA]
This clinical trial update notes that the study on spinal interneuron excitability in amyotrophic lateral sclerosis has completed. The snipp…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Identifying Biomarkers in ALS Patients Using Neuronal Derived Extracellular Vesicles
A clinical trial is recruiting to identify biomarkers in amyotrophic lateral sclerosis patients using neuronal-derived extracellular vesicle…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis [EARLY_Phase 1]
An early Phase 1 clinical trial is investigating the effects of psilocybin in patients with amyotrophic lateral sclerosis, and the study is …
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: The NO-ALS Study: A Trial of Nicotinamide/Pterostilbene Supplement in ALS. [NA]
The NO-ALS study, sponsored by Haukeland University Hospital, is evaluating a nicotinamide/pterostilbene supplement for amyotrophic lateral …
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: PREVENT ALL ALS Study
The PREVENT ALL ALS Study is currently recruiting participants to study an intervention for amyotrophic lateral sclerosis at St. Joseph's Ho…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: ASSESS ALL ALS Study
The ASSESS ALL ALS Study is currently recruiting participants for a trial addressing amyotrophic lateral sclerosis. Sponsor is St. Joseph's …
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Precise Robotically IMplanted Brain-Computer InterfacE [NA]
Neuralink reports a clinical trial update for a robotically implanted brain-computer interface that is currently recruiting for patients wit…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: This Study Evaluates the Safety, Target Engagement, and Preliminary Efficacy of Galunisertib (TGF-βR1/ALK5 Inhibitor)Combined With Nerandomilast (PDE4 Inhibitor) in GREM2-positive ALS, a Biomarker-defined Subgroup Hypothesized to Reflect Heightened TGF-β/SMAD-driven Astrocytic and Fibrotic Signaling [Phase 2, Phase 3]
This clinical trial update outlines a Phase 2/Phase 3 study evaluating the safety, target engagement, and preliminary efficacy of galunisert…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Amyotrophic Lateral Sclerosis (ALS) Families Project
Clinical trial update for the Amyotrophic Lateral Sclerosis Families Project. The study is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-01-02Clinical Trial Update: Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial [Phase 1, Phase 2]
This clinical trial update reports that the NADALS basket trial, evaluating conditions including Alzheimer's disease, amyotrophic lateral sc…
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CLINICAL_TRIALS research · 2025-12-31Clinical Trial Update: LONgitudinal and Integrated Evaluation of Biomarkers in reLation to phenotYpe in ALS [NA]
An ongoing clinical trial conducted by Istituto Auxologico Italiano evaluates biomarkers in relation to phenotype in amyotrophic lateral scl…