Amyotrophic Lateral Sclerosis
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Modeling Amyotrophic Lateral Sclerosis With Fibroblasts [NA]
A clinical trial update describes modeling amyotrophic lateral sclerosis using patient-derived fibroblasts; the study is currently recruitin…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT) [NA]
Johns Hopkins University reports a clinical trial investigating interfacing with neurotechnology to expand neural throughput for individuals…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS
A University of Alberta-led clinical trial aims to build a comprehensive analysis platform to understand, remedy, and potentially eliminate …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS [Phase 1, Phase 2]
A Phase 1/2 clinical trial is planned to evaluate the safety and tolerability of VTx-002 in participants with amyotrophic lateral sclerosis,…
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: Personalized Antisense Oligonucleotide Therapy for A Single Participant With TARDBP ALS [Phase 1, Phase 2]
A personalized antisense oligonucleotide therapy targeting TARDBP was tested in a single participant with amyotrophic lateral sclerosis in P…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic Lateral Sclerosis (ALS)
A study to learn more about the long-term safety of Tofersen (Qalsody) in participants with SOD1-associated amyotrophic lateral sclerosis is…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: A Safety and Efficacy Study of ARGX-119 in Adult Patients With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
Clinical trial update for ARGX-119 in adults with amyotrophic lateral sclerosis (ALS), a Phase 2 safety and efficacy study currently active …
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CLINICAL_TRIALS withdrawal · 2026-04-07Clinical Trial Update: Two Intermediate Expanded Access Protocols (EAP) CNMAu8.EAP01 and CNMAu8.EAP02 for ALS
Two intermediate Expanded Access Protocols for CNM-Au8 (CNMAu8.EAP01 and CNMAu8.EAP02) in amyotrophic lateral sclerosis are no longer availa…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Intermediate Expanded Access Protocol CNMAu8.EAP04
This update notes that the intermediate expanded access protocol CNMAu8.EAP04 for Amyotrophic Lateral Sclerosis is temporarily not available…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study [NA]
This document provides an update on the MI-PALS trial investigating mechanical insufflation in a Philadelphia ALS cohort; the study status i…
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CLINICAL_TRIALS trial_result · 2026-04-07Clinical Trial Update: A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
A Phase 2 clinical trial to evaluate the effects of VHB937 in people with amyotrophic lateral sclerosis is active but not currently recruiti…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Examining Interactions Between PALS and Caregivers [NA]
A clinical trial investigating interactions between people living with ALS and their caregivers, sponsored by Penn State University, current…
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CLINICAL_TRIALS trial_result · 2026-04-03Clinical Trial Update: A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD [Phase 2]
Phase 2a study of TPN-101 in patients with C9ORF72-associated ALS/FTD has completed.
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders [NA]
Clinical trial update for a study of Ultra-High Resolution PET imaging in aging, neurodegeneration and psychotic disorders; recruitment is o…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS [Phase 2]
A Phase 2 clinical trial evaluating cromolyn (PHENOGENE-1A) for amyotrophic lateral sclerosis is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients [Phase 1]
Phase 1 trial update for TCD601 (Siplizumab) in newly diagnosed adult amyotrophic lateral sclerosis patients; recruitment is ongoing.
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Diagnostic Accuracy of SleepImage Technology for Detecting Respiratory Failure in Patients With Amyotrophic Lateral Sclerosis
A clinical trial is evaluating the diagnostic accuracy of SleepImage Technology to detect respiratory failure in patients with amyotrophic l…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Study of BIIB067 (Tofersen) Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation [Phase 3]
Biogen initiated a Phase 3 trial of tofersen (BIIB067) in presymptomatic adults with a confirmed SOD1 mutation for amyotrophic lateral scler…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Dazucorilant in Patients With Amyotrophic Lateral Sclerosis [Phase 2]
Corcept Therapeutics is conducting a Phase 2 trial of dazucorilant in patients with amyotrophic lateral sclerosis, currently recruiting.
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches
A clinical trial investigating disease biosignatures in the ALS/FTD spectrum, exploring biological perspectives beyond traditional clinical …
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: ALS Diagnosis From a Saliva Sample: a Non-coding RNA Analysis Approach
Clinical trial assessing a saliva-based non-coding RNA analysis method to aid diagnosis of amyotrophic lateral sclerosis.
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Adenosine 2A Receptor Antagonism and AIH in ALS [Phase 1, Phase 2]
Clinical trial update on an Adenosine A2A receptor antagonist approach for amyotrophic lateral sclerosis (Phase 1/Phase 2; active not recrui…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Intermediate-size Patient Population Expanded Access Protocol
Spinogenix updated its expanded access protocol for an investigational ALS therapy targeting an intermediate-sized patient population. The u…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Evaluation of a Structurally Suitable Neck Exoskeleton in Patients With Amyotrophic Lateral Sclerosis [NA]
This clinical trial update describes a study evaluating a neck exoskeleton designed for individuals with amyotrophic lateral sclerosis, with…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Impact of Physical Functioning on Patient-Reported Outcomes in ALS Patients at TidalHealth
This clinical trial update from TidalHealth investigates the relationship between physical functioning and patient-reported outcomes in amyo…