Amyotrophic Lateral Sclerosis
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CLINICAL_TRIALS research · 2024-06-04Clinical Trial Update: potentiALS - Quality of Life Among Patients With Amyotrophic Lateral Sclerosis
A clinical trial update for PotentiALS investigating quality of life in patients with amyotrophic lateral sclerosis; the study is currently …
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CLINICAL_TRIALS research · 2024-05-23Clinical Trial Update: Validation of Czech Language Versions of Questionnaires for ALS Patients' Functional Status and Biomarker Long-term Follow-up
This clinical trial update reports validation of Czech-language versions of ALS patient questionnaires and plans long-term biomarker follow-…
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CLINICAL_TRIALS research · 2024-05-17Clinical Trial Update: Patients' and Caregivers' Views of Multidimensional Care in Amyotropic Lateral Sclerosis in Germany
This clinical trial update indicates an ongoing study at Technische Universität Dresden exploring multidimensional care from patients' and c…
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CLINICAL_TRIALS trial_result · 2024-05-16Clinical Trial Update: Reducing Disparities in the Quality of Advance Care Planning for Older Adults [NA]
A Duke University-sponsored trial examining disparities in the quality of advance care planning for older adults has completed.
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CLINICAL_TRIALS research · 2024-05-16Clinical Trial Update: Efficacy and Safety of Deep Cervical Lymph Node-vein Bypass Surgery in ALS Amyotrophic Lateral Sclerosis
A clinical trial update on a surgical approach called deep cervical lymph node-vein bypass for amyotrophic lateral sclerosis, reporting on e…
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CLINICAL_TRIALS research · 2024-05-16Clinical Trial Update: Optimizing INITIation of Non-invasive Ventilation in ALS Patients
This clinical trial update describes a study to optimize the initiation of non-invasive ventilation in patients with amyotrophic lateral scl…
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CLINICAL_TRIALS other · 2024-05-08Clinical Trial Update: Efficacy and Tolerability of Beta Hydroxybutyrate Ester in Patients With Amyotrophic Lateral Sclerosis (ALS) [NA]
Clinical trial update noting recruitment for a study evaluating the efficacy and tolerability of beta hydroxybutyrate ester in patients with…
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FDA approval · 2024-05-06FDA Approved: EDARAVONE — Original Application (Gland Pharma Limited)
FDA approved the original ANDA for edaravone submitted by Gland Pharma Limited, establishing a generic version of the ALS treatment. This ap…
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CLINICAL_TRIALS trial_result · 2024-05-01Clinical Trial Update: Environmental Exposure and Neurological Diseases Questionnaire
The trial update notes the completion of a Dartmouth-Hitchcock study examining environmental exposure and its relation to neurological disea…
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CLINICAL_TRIALS research · 2024-04-30Clinical Trial Update: Nerve Growth Factor Encapsulated With 2-methacryloyloxyethyl Phosphorylcholine Nanocapsules in the Treatment of Amyotrophic Lateral Sclerosis [Phase 2, Phase 3]
A Phase 2/3 clinical trial evaluates nerve growth factor delivered via MPC nanocapsules for amyotrophic lateral sclerosis, and the study is …
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CLINICAL_TRIALS trial_result · 2024-02-29Clinical Trial Update: Safety and Efficacy of Repeated Administrations of NurOwn® in ALS Patients [Phase 3]
Phase 3 trial assessing repeated administrations of NurOwn for amyotrophic lateral sclerosis (ALS) has completed with results posted.
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CLINICAL_TRIALS trial_result · 2024-02-14Clinical Trial Update: Olanzapine for the Treatment of Appetite Loss in Amyotrophic Lateral Sclerosis (ALS) [Phase 2, Phase 3]
Phase 2/Phase 3 trial investigating olanzapine for appetite loss in amyotrophic lateral sclerosis has completed.
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CLINICAL_TRIALS trial_result · 2024-02-14Clinical Trial Update: Safety and Tolerability of Anakinra in Combination With Riluzol in Amyotrophic Lateral Sclerosis [Phase 2]
A Phase 2 clinical trial evaluated the safety and tolerability of combining anakinra with riluzole in patients with amyotrophic lateral scle…
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EMA withdrawal · 2024-02-01EMA Refused: Albrioza (sodium phenylbutyrate;ursodoxicoltaurine) — Amylyx Pharmaceuticals EMEA B.V.
The EMA refused approval for Albrioza (sodium phenylbutyrate; ursodoxicoltaurine) for amyotrophic lateral sclerosis.
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CLINICAL_TRIALS trial_result · 2024-01-26Clinical Trial Update: Enoxacin for Amyotrophic Lateral Sclerosis (ALS) [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating enoxacin for amyotrophic lateral sclerosis has completed.
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CLINICAL_TRIALS trial_result · 2024-01-24Clinical Trial Update: Clinical Pharmacology Study of Oral Edaravone in Amyotrophic Lateral Sclerosis Patients With Gastrostomy [Phase 1]
Phase 1 pharmacology study evaluating oral edaravone in amyotrophic lateral sclerosis patients with gastrostomy; results have been posted.
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CLINICAL_TRIALS trial_result · 2024-01-24Clinical Trial Update: Clinical Pharmacology Study of Oral Edaravone in Patients With Amyotrophic Lateral Sclerosis [Phase 1]
A Phase 1 clinical pharmacology study evaluating oral edaravone in Japanese patients with amyotrophic lateral sclerosis has completed, with …
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CLINICAL_TRIALS trial_result · 2024-01-09Clinical Trial Update: HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS) [Phase 1]
Phase 1 clinical trial evaluating suppression of HERV-K with antiretroviral therapy in volunteers with amyotrophic lateral sclerosis has com…
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CLINICAL_TRIALS trial_result · 2023-11-30Clinical Trial Update: Inhibition of Rho Kinase (ROCK) With Fasudil as Disease-modifying Treatment for ALS [Phase 2]
Phase 2 clinical trial investigating ROCK inhibitor fasudil as a disease-modifying treatment for amyotrophic lateral sclerosis has completed…
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CLINICAL_TRIALS trial_result · 2023-11-22Clinical Trial Update: Clinical Study to Evaluate the Efficacy and Safety of FB1006 in the Treatment of ALS Patients [Phase 4]
A Phase 4 clinical trial evaluating the efficacy and safety of FB1006 in treating amyotrophic lateral sclerosis is currently recruiting.
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FDA approval · 2023-10-17FDA Approved: RILUZOLE — Supplemental Application (Florida Pharmaceutical Products, LLC)
FDA approved a supplemental application for riluzole by Florida Pharmaceutical Products, LLC, confirming approval status for a generic riluz…
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CLINICAL_TRIALS trial_result · 2023-10-11Clinical Trial Update: 3K3A-APC for Treatment of Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
Phase 2 clinical trial of 3K3A-APC for amyotrophic lateral sclerosis has completed; results posted in 2023.
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CLINICAL_TRIALS trial_result · 2023-09-29Clinical Trial Update: Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS) [Phase 2, Phase 3]
A clinical trial update reports Phase 2 and Phase 3 studies of masitinib in combination with riluzole for ALS; the trial status is completed…
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CLINICAL_TRIALS trial_result · 2023-09-28Clinical Trial Update: Trial of Theracurmin for Patients With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
Phase 2 trial results for Theracurmin in amyotrophic lateral sclerosis have been completed with results posted in 2023.
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CLINICAL_TRIALS trial_result · 2023-09-21Clinical Trial Update: Safety Study of VM202 to Treat Amyotrophic Lateral Sclerosis [Phase 1, Phase 2]
Safety study results for VM202 in amyotrophic lateral sclerosis (Phase 1/Phase 2) have been completed, and results were posted in September …