Amyotrophic Lateral Sclerosis
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CLINICAL_TRIALS trial_result · 2025-12-30Clinical Trial Update: New Therapeutic Strategy in ALS Based on Metabolic Status and Associated Metabolic Pathways. [NA]
A completed clinical trial update describes a metabolic-status–driven therapeutic strategy for amyotrophic lateral sclerosis. The study was …
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CLINICAL_TRIALS trial_result · 2025-12-24Clinical Trial Update: ALS Phase II Study of NX210c [Phase 2]
A Phase II clinical trial of NX210c for Amyotrophic Lateral Sclerosis is currently active but not recruiting.
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CLINICAL_TRIALS trial_result · 2025-12-22Clinical Trial Update: Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis [NA]
A completed clinical trial evaluating ocular surface metabolo-lipidomics in individuals with amyotrophic lateral sclerosis.
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CLINICAL_TRIALS trial_result · 2025-12-19Clinical Trial Update: An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS [Phase 2]
Open-label extension update for a Phase 2 study evaluating CNM-Au8 in early symptomatic ALS patients on stable background therapy to slow di…
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CLINICAL_TRIALS trial_result · 2025-12-18Clinical Trial Update: A Study of STRO4 in Patients Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
A Phase 2 study of STRO4 in patients with amyotrophic lateral sclerosis has been terminated. The entry notes sponsor and trial status but do…
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CLINICAL_TRIALS trial_result · 2025-12-17Clinical Trial Update: Extension Study of Participants From SPG302-ALS-001 [Phase 2]
An extension study of SPG302-ALS-001 in participants with amyotrophic lateral sclerosis has been terminated.
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: A Study of VRG50635 in Participants With Amyotrophic Lateral Sclerosis (ALS) [Phase 1]
A Phase 1 study of VRG50635 for amyotrophic lateral sclerosis has been terminated.
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: Conservative Iron Chelation as a Disease-modifying Strategy in Amyotrophic Lateral Sclerosis [Phase 2, Phase 3]
This document reports a Phase 2/Phase 3 clinical trial evaluating conservative iron chelation as a disease-modifying strategy for amyotrophi…
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CLINICAL_TRIALS trial_result · 2025-12-04Clinical Trial Update: MIROCALS: Modifying Immune Response and OutComes in ALS [Phase 2]
MIROCALS is a Phase 2 trial aimed at modifying immune response and outcomes in amyotrophic lateral sclerosis; the study has completed.
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CLINICAL_TRIALS trial_result · 2025-12-03Clinical Trial Update: Comprehensive Biomarker Profiling of the IFN-α Pathway in Amyotrophic Lateral Sclerosis Patient Biofluids
Completed clinical trial investigating biomarkers of the interferon-alpha pathway in Amyotrophic Lateral Sclerosis patient biofluids.
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CLINICAL_TRIALS trial_result · 2025-12-02Clinical Trial Update: Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD [Phase 2]
Phase 2 study evaluating safety and therapeutic potential of metformin for C9orf72-related ALS/FTD, with results posted in December 2025.
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CLINICAL_TRIALS trial_result · 2025-11-21Clinical Trial Update: Study of Gene Polymorphisms Involved in the Metabolism and Action of Vitamin D in Amyotrophic Lateral Sclerosis
A completed clinical trial investigating gene polymorphisms involved in Vitamin D metabolism and action in Amyotrophic Lateral Sclerosis.
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CLINICAL_TRIALS trial_result · 2025-11-18Clinical Trial Update: From Movement Preparation to Gait Execution in ALS
The trial update indicates that the study on movement preparation to gait execution in amyotrophic lateral sclerosis has completed.
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Immuno-modulation in Amyotrophic Lateral Sclerosis- a Phase II Study of Safety and Activity of Low Dose Interleukin-2 [Phase 2]
Phase II trial assessing safety and activity of low-dose Interleukin-2 in amyotrophic lateral sclerosis has completed.
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CLINICAL_TRIALS trial_result · 2025-11-14Clinical Trial Update: HEALEY ALS Platform Trial - Regimen F ABBV-CLS-7262 [Phase 2, Phase 3]
The HEALEY ALS Platform Trial's Regimen F with ABBV-CLS-7262 completed Phase 2 and Phase 3 cohorts, with trial results posted on 2025-11-14.
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS [NA]
Results from a study on remote ischemic conditioning and hand use in individuals with spinal cord injury and amyotrophic lateral sclerosis h…
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CLINICAL_TRIALS trial_result · 2025-10-10Clinical Trial Update: Treatment Combining Riluzole and IFB-088 in Bulbar Amyotrophic Lateral Sclerosis (TRIALS Protocol) [Phase 2]
A Phase 2 trial evaluating the combination of riluzole and IFB-088 for bulbar amyotrophic lateral sclerosis has completed with results poste…
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CLINICAL_TRIALS trial_result · 2025-10-09Clinical Trial Update: A Study to Assess the Safety, Tolerability, and Effect on Disease Progression of BIIB105 in Participants With Amyotrophic Lateral Sclerosis (ALS) and Participants With the ALS Ataxin-2 (ATXN2) Genetic Mutation [Phase 1, Phase 2]
A Phase 1/2 study evaluating BIIB105 in amyotrophic lateral sclerosis (including participants with the ATXN2 genetic mutation) was terminate…
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CLINICAL_TRIALS trial_result · 2025-10-08Clinical Trial Update: Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients [Phase 2]
A Phase 2 clinical trial evaluating the combined treatment of Liposomed Polyphenols with G04CB02 in amyotrophic lateral sclerosis has comple…
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CLINICAL_TRIALS trial_result · 2025-09-29Clinical Trial Update: Individual Patient Expanded Access IND of Autologous HBadMSCs for the Treatment of Amyotrophic Lateral Sclerosis
Update on an individual patient expanded access IND using autologous HBadMSCs to treat amyotrophic lateral sclerosis. The status shows the t…
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CLINICAL_TRIALS trial_result · 2025-09-26Clinical Trial Update: ROAR-DIGAP: A Widely Inclusive, Largely Virtual Pilot Trial Utilizing DIGAP (Deep Integrated Genomics Analysis Platform) To Personalize Treatments [Phase 2]
Phase 2 clinical trial update for ROAR-DIGAP, a Duke University pilot study using the Deep Integrated Genomics Analysis Platform to personal…
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CLINICAL_TRIALS trial_result · 2025-09-25Clinical Trial Update: Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS [Phase 2, Phase 3]
An ongoing Phase 2/Phase 3 trial is evaluating the biological and clinical effects of Acetyl-L-carnitine in amyotrophic lateral sclerosis an…
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CLINICAL_TRIALS trial_result · 2025-09-22Clinical Trial Update: Study to Evaluate DNL747 in Subjects With Amyotrophic Lateral Sclerosis [Phase 1]
A Phase 1 study evaluating the investigational drug DNL747 for amyotrophic lateral sclerosis has been terminated.
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CLINICAL_TRIALS trial_result · 2025-09-19Clinical Trial Update: Polish Version Dyspnea in Amyotrophic Lateral Sclerosis
An update indicates that the Polish version of a clinical trial investigating dyspnea in amyotrophic lateral sclerosis is not yet recruiting…
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CLINICAL_TRIALS trial_result · 2025-09-17Clinical Trial Update: Longitudinal Evaluation of Short-Chain Fatty Acid Profiles During the Natural Disease Course and a Mediterranean Diet Intervention in Amyotrophic Lateral Sclerosis Patients
Clinical trial update announcing completion of a study examining longitudinal short-chain fatty acid profiles in the natural course of amyot…