Clinical Trial Update: Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD [Phase 2]

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Summary

Phase 2 study evaluating safety and therapeutic potential of metformin for C9orf72-related ALS/FTD, with results posted in December 2025.

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Diseases / indications

• Amyotrophic Lateral Sclerosis
• Frontotemporal Dementia

Drugs mentioned

• metformin (metformin)

Snippet

Sponsor: University of Florida | Conditions: C9orf72 Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia | Phase 2 | Status: ACTIVE_NOT_RECRUITING | Results posted: 2025-12-02