Amyotrophic Lateral Sclerosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: Augmented Reality BCI Longitudinal Study for Persons With ALS, Stroke, TBI and SCI Utilizing Cognixion + Apple Vision Pro [NA]
Update on a longitudinal study evaluating an augmented reality brain-computer interface using Cognixion and Apple Vision Pro for people with…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
An ongoing sponsor-initiated study is evaluating metabolism, connectivity, and ultra-high-field mesoscopic imaging to uncover mechanisms of …
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS) [Phase 1]
This entry notes a Phase 1 clinical trial evaluating intravenous immunoglobulin with blood-brain barrier disruption for amyotrophic lateral …
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Clinical Study of Regulatory T Cells (Tregs) in the Treatment of Neurodegenerative Diseases [Phase 1]
A Phase 1 clinical trial evaluating regulatory T cell therapy for amyotrophic lateral sclerosis is currently recruiting, sponsored by Novabi…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease [NA]
This clinical trial entry describes a study evaluating non-invasive brain stimulation in combination with exercise for patients with Amyotro…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Analysis of Human ALS Tissues and Registry of ALS Patients
A clinical trial update for NCT05067179 investigating analysis of human ALS tissues and a registry of ALS patients, currently recruiting.
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Amyotrophic Lateral Sclerosis Registry in Thailand
A clinical trial registry entry for an ALS registry in Thailand, sponsored by Chulalongkorn University. The study is currently recruiting.
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Safety and Efficacy of Intravenous Administration of SHED-CM for ALS [EARLY_Phase 1]
An early-phase clinical trial evaluates the safety and potential efficacy of intravenous SHED-CM for amyotrophic lateral sclerosis, sponsore…
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Electrophysiology and Ultrasound of Respiratory Muscles and Respective Nerves to Predict Respiratory Insufficiency in ALS
This clinical trial is evaluating electrophysiology and ultrasound of respiratory muscles and nerves to predict respiratory insufficiency in…
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CLINICAL_TRIALS research · 2025-09-12Clinical Trial Update: Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients [Phase 3]
Ongoing Phase 3 trial evaluating the efficacy and safety of masitinib versus placebo in patients with amyotrophic lateral sclerosis; the stu…
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CLINICAL_TRIALS research · 2025-09-12Clinical Trial Update: Dynamic Impact of NIV on Diaphragmatic Ultrasound in Patients With Amyotrophic Lateral Sclerosis
This is a clinical trial update studying how non-invasive ventilation affects diaphragmatic ultrasound in patients with amyotrophic lateral …
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: A Phase Ⅰ/Ⅱa Study of SNUG01 in Adult Subjects With ALS [Phase 1, Phase 2]
Phase 1/2a clinical trial of SNUG01 for amyotrophic lateral sclerosis is not yet recruiting.
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: Development and Validation of the FBIndex to Determine the Risk of Falls for Patients With Neuromuscular Disorders
Development and validation of the FBIndex, a tool to assess falls risk in patients with various neuromuscular disorders.
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: A Study to Assess the Safety, Tolerability, and Pharmacology of Darifenacin in Patients With ALS [Phase 2]
A Phase 2 clinical trial is evaluating the safety, tolerability, and pharmacology of darifenacin in patients with amyotrophic lateral sclero…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: An IIT Clinical Study to Evaluate the Safety and Efficacy of a Single Intrathecal Injection of RJK002 in Patients With ALS [EARLY_Phase 1]
The document describes an investigator-initiated Phase 1 study to assess the safety and efficacy of a single intrathecal injection of RJK002…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families [NA]
This clinical trial evaluates the impact of long-term ventilation support on quality of life for people with amyotrophic lateral sclerosis a…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: Amyotrophic Lateral Sclerosis: A Multicenter Retrospective Observational Registry
This entry describes a multicenter retrospective observational registry for amyotrophic lateral sclerosis that is currently active but not r…
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CLINICAL_TRIALS research · 2025-08-24Clinical Trial Update: Mitochondrial Capacity Boost in ALS (MICABO-ALS) Trial [Phase 2]
The MICABO-ALS trial is a Phase 2 study aimed at boosting mitochondrial capacity in amyotrophic lateral sclerosis and is currently recruitin…
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: CNS10-NPC-GDNF Delivered to the Motor Cortex for ALS [Phase 1]
Phase 1 clinical trial update for CNS10-NPC-GDNF delivered to the motor cortex in amyotrophic lateral sclerosis.
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders
ClinicalTrials.gov entry indicates Mayo Clinic–sponsored studies are actively recruiting for trials addressing amyotrophic lateral sclerosis…
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and Its Impact on Formula Intolerance in pALS [NA]
A clinical trial evaluating whether pre-feeding with an enteral nutrition formula before G-tube placement reduces formula intolerance in ind…
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CLINICAL_TRIALS research · 2025-08-17Clinical Trial Update: GB-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices [NA]
An early-feasibility study of a robotically implanted brain-computer interface (GB-PRIME) by Neuralink for controlling external devices. Rec…
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: Human Amniotic Mesenchymal Cell Secretome for Neurodegeneration and Neuroinflammation [NA]
A clinical trial evaluating the use of human amniotic mesenchymal cell secretome for neurodegeneration and neuroinflammation, with recruitme…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis
This clinical trial update describes AIM's Writing for Healing workshop for people living with paralysis, sponsored by the University of Ala…
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CLINICAL_TRIALS research · 2025-08-05Clinical Trial Update: Personalized Antisense Oligonucleotide Therapy for A Single Participant With CHCHD10 ALS [Phase 1, Phase 2]
A single-participant Phase 1/2 trial is evaluating a personalized antisense oligonucleotide therapy for CHCHD10-related amyotrophic lateral …