On Chronic Liver Failure
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CLINICAL_TRIALS research · 2024-12-10Clinical Trial Update: COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device [NA]
Clinical trial update for the COOLEY study evaluating the CytoSorb hemoadsorption device in acute-on-chronic liver failure; the study is cur…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF [NA]
A recruiting clinical trial evaluating three nucleotide/nucleoside analogue therapies for hepatitis B-related acute-on-chronic liver failure…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF
A clinical trial is recruiting to evaluate the combination of DPMAS and low-volume plasma exchange for patients with chronic hepatitis B-rel…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Long-term Prognosis of Patients With Hepatitis B Related Acute-on-chronic Liver Failure
A study assessing the long-term prognosis of patients with hepatitis B-related acute-on-chronic liver failure is currently recruiting.
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CLINICAL_TRIALS research · 2024-08-16Clinical Trial Update: Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in Improving Outcomes of Acute Kidney Injury in Acute on Chronic Liver Failure With Septic Shock [NA]
A clinical trial update evaluating whether continuous infusion of terlipressin with norepinephrine improves outcomes compared with norepinep…
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CLINICAL_TRIALS withdrawal · 2024-08-01Clinical Trial Update: Characterization of Metabolomic Fingerprints in Patients With Acute Liver Failure and Acute-on-chronic Liver Failure With Hepatic Encephalopathy
A clinical trial investigating metabolomic fingerprints in patients with hepatic encephalopathy, acute liver failure, and acute-on-chronic l…
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CLINICAL_TRIALS trial_result · 2024-06-25Clinical Trial Update: MERTK Signalling in Monocytes/Macrophages in Patients With Liver Disease
Completed clinical trial examining MERTK signalling in monocytes/macrophages in patients with liver disease.
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CLINICAL_TRIALS research · 2024-05-31Clinical Trial Update: Study on Prognosis of Acute-on-chronic Liver Failure Complicated by Bacterial or Fungal Infection
A clinical trial sponsored by Qin Ning is recruiting to study the prognosis of acute-on-chronic liver failure when complicated by bacterial …
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CLINICAL_TRIALS trial_result · 2024-05-29Clinical Trial Update: HepaStem Long-Term Safety Registry
This clinical trial update announces the termination of the HepaStem long-term safety registry and highlights conditions studied (urea cycle…
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CLINICAL_TRIALS trial_result · 2024-05-22Clinical Trial Update: Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF) [Phase 2]
A Phase 2 trial evaluating HepaStem for acute-on-chronic liver failure has been terminated.
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CLINICAL_TRIALS research · 2024-05-07Clinical Trial Update: Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure [Phase 1, Phase 2]
This clinical trial is a Phase 1/Phase 2 study evaluating human umbilical cord mesenchymal stem cell transplantation for acute-on-chronic li…
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CLINICAL_TRIALS research · 2024-04-26Clinical Trial Update: To Determine the Predictors of Reversibility for Acute-on-Chronic Liver Failure at 6-months.
This clinical trial update aims to identify predictors of reversibility for acute-on-chronic liver failure at 6 months.
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CLINICAL_TRIALS trial_result · 2023-05-24Clinical Trial Update: Efficacy of the Combination of Simvastatin Plus Rifaximin in Patients With Decompensated Cirrhosis to Prevent ACLF Development [Phase 2, Phase 3]
A Phase 2/3 trial evaluated simvastatin plus rifaximin in decompensated cirrhosis to prevent acute-on-chronic liver failure (ACLF).
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CLINICAL_TRIALS trial_result · 2022-11-10Clinical Trial Update: Efficacy and Safety of Avatrombopag for Treating TCP in HBV-ACLF Patients Receiving ALSS Treatment [Phase 4]
Phase 4 clinical trial investigating the efficacy and safety of avatrombopag for thrombocytopenia in patients with HBV-related acute-on-chro…
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CLINICAL_TRIALS trial_result · 2022-07-01Clinical Trial Update: 20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension [Phase 4]
Phase 4 trial comparing 20% albumin to balanced salt solution for resuscitation in cirrhosis with sepsis-induced hypotension; status current…
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CLINICAL_TRIALS trial_result · 2021-08-02Clinical Trial Update: TAK-242 in Patients With Acute Alcoholic Hepatitis [Phase 2]
Phase 2 clinical trial update for TAK-242 in patients with acute-on-chronic liver failure.
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CLINICAL_TRIALS trial_result · 2021-07-21Clinical Trial Update: Safety of UC-MSC Transfusion for ACLF Patients [Phase 2]
Phase 2 clinical trial update evaluating safety of umbilical cord-derived mesenchymal stem cell transfusion in patients with acute-on-chroni…
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CLINICAL_TRIALS trial_result · 2020-10-14Clinical Trial Update: Phase II Safety Study of 2 Dose Regimens of HepaStem in Patients With ACLF [Phase 2]
Phase II safety study comparing two dose regimens of HepaStem in patients with Acute-On-Chronic Liver Failure has completed.
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CLINICAL_TRIALS trial_result · 2020-04-28Clinical Trial Update: Study to Evaluate Safety and Efficacy of LifeLiver in Acute or Acute-on-Chronic Liver Failure Patients [Phase 2]
Phase 2 clinical trial evaluating safety and efficacy of LifeLiver in acute liver failure and acute-on-chronic liver failure.
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CLINICAL_TRIALS trial_result · 2020-01-28Clinical Trial Update: Use of HA 330-II for Hemofiltration in Patients With ALF as a Bridge to Liver Transplantation . [Phase 4]
Phase 4 clinical trial update evaluating HA 330-II hemofiltration as a bridge to liver transplantation in patients with acute-on-chronic liv…
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CLINICAL_TRIALS trial_result · 2020-01-22Clinical Trial Update: Chinese CLIF-C Acute-on-Chronic Liver Disease and Liver Failure Study
A completed clinical trial on acute-on-chronic liver failure in China has posted results.
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CLINICAL_TRIALS trial_result · 2019-08-09Clinical Trial Update: Plasma Exchange in Acute on Chronic Liver Failure [Phase 3]
A Phase 3 clinical trial evaluating plasma exchange for acute on chronic liver failure in cirrhosis patients is in progress, with status cur…
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CLINICAL_TRIALS trial_result · 2019-06-17Clinical Trial Update: PEG3350 in ACLF With Hepatic Encephalopathy [Phase 4]
Clinical trial update for PEG3350 in acute-on-chronic liver failure with hepatic encephalopathy (Phase 4) is ongoing with an unknown status.
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CLINICAL_TRIALS research · 2019-02-07Clinical Trial Update: Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure" [NA]
This document provides a clinical trial update on plasma exchange in cirrhotic patients with acute-on-chronic liver failure, focusing on eff…
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CLINICAL_TRIALS other · 2018-07-18Clinical Trial Update: Clinical Features and Natural History of Acute-on-Chronic Liver Failure in Korean Patients With Chronic Liver Disease
This clinical trial update notes that the study on acute-on-chronic liver failure in Korean patients with chronic liver disease has been sus…