On Chronic Liver Failure
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CLINICAL_TRIALS trial_result · 2026-07-23Clinical Trial Results: Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)® [Phase 2]
Phase 2 trial evaluating VS-01 in adults with acute-on-chronic liver failure and ascites; study terminated with posted results.
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CLINICAL_TRIALS trial_result · 2026-06-04Clinical Trial Results: Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5% [Phase 3]
Phase 3 trial evaluating short-term survival of acute-on-chronic liver failure patients treated with plasma exchange using 5% human serum al…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced Coagulopathy [NA]
The document reports a completed clinical trial evaluating goal-directed hemostatic resuscitation for coagulopathy associated with acute-on-…
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 Trial [Phase 1]
Phase 1 trial of miroliverELAP for acute liver failure has been completed. The document provides an update on the trial status by Miromatrix…
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CLINICAL_TRIALS trial_result · 2026-01-16Clinical Trial Update: Pharmacokinetic Study on G1090N (Nitazoxanide) Capsules in Healthy Volunteers [Phase 1]
Phase 1 pharmacokinetic study of G1090N (Nitazoxanide) capsules in healthy volunteers to characterize drug exposure. The trial is sponsored …
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CLINICAL_TRIALS trial_result · 2026-01-14Clinical Trial Update: Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)® [Phase 2]
Phase 2 study of VS-01 in adults with acute-on-chronic liver failure and ascites has been terminated. No further results are being reported …
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic Encephalopathy [Phase 2]
Genfit's Phase 2 trial of the investigational medicine VS-01 for hepatic encephalopathy in patients with acute-on-chronic liver failure and …
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CLINICAL_TRIALS trial_result · 2025-12-16Clinical Trial Update: Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5% [Phase 3]
A Phase 3 trial evaluating plasma exchange with 5% human serum albumin for acute-on-chronic liver failure was terminated.
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CLINICAL_TRIALS trial_result · 2025-09-02Clinical Trial Update: Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension
This entry notes the completion of a clinical trial evaluating volume resuscitation in patients with cirrhosis and sepsis-induced hypotensio…
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CLINICAL_TRIALS trial_result · 2025-08-17Clinical Trial Update: National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial [Phase 3]
A Phase 3 clinical trial evaluating mesenchymal stem-cell therapy for acute-on-chronic liver failure (ACLF) due to non-viral causes, sponsor…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF) [Phase 1]
A Phase 1 trial assessing intravenous branched-chain amino acids for hepatic encephalopathy in patients with acute-on-chronic liver failure …
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients [NA]
This clinical trial update reports the completion of a study evaluating anti-fungal strategies in patients with acute-on-chronic liver failu…
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CLINICAL_TRIALS trial_result · 2025-03-19Clinical Trial Update: Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating ACLF [Phase 2, Phase 3]
This clinical trial investigates umbilical cord-derived mesenchymal stem cell infusions for acute-on-chronic liver failure, spanning Phase 2…
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CLINICAL_TRIALS trial_result · 2025-01-22Clinical Trial Update: Utility of Liver and Splenic Stiffness in Predicting Esophageal Varices in Patients With Acute on Chronic Liver Failure
A completed clinical trial evaluated whether liver and splenic stiffness measurements can predict esophageal varices in patients with acute-…
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CLINICAL_TRIALS trial_result · 2024-06-25Clinical Trial Update: MERTK Signalling in Monocytes/Macrophages in Patients With Liver Disease
Completed clinical trial examining MERTK signalling in monocytes/macrophages in patients with liver disease.
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CLINICAL_TRIALS trial_result · 2024-05-29Clinical Trial Update: HepaStem Long-Term Safety Registry
This clinical trial update announces the termination of the HepaStem long-term safety registry and highlights conditions studied (urea cycle…
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CLINICAL_TRIALS trial_result · 2024-05-22Clinical Trial Update: Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF) [Phase 2]
A Phase 2 trial evaluating HepaStem for acute-on-chronic liver failure has been terminated.
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CLINICAL_TRIALS trial_result · 2023-05-24Clinical Trial Update: Efficacy of the Combination of Simvastatin Plus Rifaximin in Patients With Decompensated Cirrhosis to Prevent ACLF Development [Phase 2, Phase 3]
A Phase 2/3 trial evaluated simvastatin plus rifaximin in decompensated cirrhosis to prevent acute-on-chronic liver failure (ACLF).
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CLINICAL_TRIALS trial_result · 2022-11-10Clinical Trial Update: Efficacy and Safety of Avatrombopag for Treating TCP in HBV-ACLF Patients Receiving ALSS Treatment [Phase 4]
Phase 4 clinical trial investigating the efficacy and safety of avatrombopag for thrombocytopenia in patients with HBV-related acute-on-chro…
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CLINICAL_TRIALS trial_result · 2022-07-01Clinical Trial Update: 20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension [Phase 4]
Phase 4 trial comparing 20% albumin to balanced salt solution for resuscitation in cirrhosis with sepsis-induced hypotension; status current…
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CLINICAL_TRIALS trial_result · 2021-08-02Clinical Trial Update: TAK-242 in Patients With Acute Alcoholic Hepatitis [Phase 2]
Phase 2 clinical trial update for TAK-242 in patients with acute-on-chronic liver failure.
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CLINICAL_TRIALS trial_result · 2021-07-21Clinical Trial Update: Safety of UC-MSC Transfusion for ACLF Patients [Phase 2]
Phase 2 clinical trial update evaluating safety of umbilical cord-derived mesenchymal stem cell transfusion in patients with acute-on-chroni…
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CLINICAL_TRIALS trial_result · 2020-10-14Clinical Trial Update: Phase II Safety Study of 2 Dose Regimens of HepaStem in Patients With ACLF [Phase 2]
Phase II safety study comparing two dose regimens of HepaStem in patients with Acute-On-Chronic Liver Failure has completed.
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CLINICAL_TRIALS trial_result · 2020-04-28Clinical Trial Update: Study to Evaluate Safety and Efficacy of LifeLiver in Acute or Acute-on-Chronic Liver Failure Patients [Phase 2]
Phase 2 clinical trial evaluating safety and efficacy of LifeLiver in acute liver failure and acute-on-chronic liver failure.
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CLINICAL_TRIALS trial_result · 2020-01-28Clinical Trial Update: Use of HA 330-II for Hemofiltration in Patients With ALF as a Bridge to Liver Transplantation . [Phase 4]
Phase 4 clinical trial update evaluating HA 330-II hemofiltration as a bridge to liver transplantation in patients with acute-on-chronic liv…