On Chronic Liver Failure
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CLINICAL_TRIALS research · 2025-08-20Clinical Trial Update: National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial [Phase 2]
Phase II clinical trial evaluating mesenchymal stem cell therapy for non-viral acute-on-chronic liver failure; currently not yet recruiting,…
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CLINICAL_TRIALS trial_result · 2025-08-17Clinical Trial Update: National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial [Phase 3]
A Phase 3 clinical trial evaluating mesenchymal stem-cell therapy for acute-on-chronic liver failure (ACLF) due to non-viral causes, sponsor…
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CLINICAL_TRIALS research · 2025-08-11Clinical Trial Update: Prognosis of Cirrhotic Patients Admitted to the General Intensive Care Unit Between 2014 and 2024: a Regional Retrospective Multicentre Cohort Study
A multicenter retrospective cohort study assessing prognosis of cirrhotic patients admitted to general intensive care units from 2014–2024. …
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: A-TANGO Phase 2 Study [Phase 2]
A-TANGO is a Phase 2 clinical trial by Yaqrit Ltd evaluating an investigational therapy for acute-on-chronic liver failure and alcoholic hep…
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: Biomarkers in Liver Failure
A University of Edinburgh–sponsored biomarker study on liver failure, covering acute liver failure, acute liver injury, and acute-on-chronic…
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CLINICAL_TRIALS research · 2025-07-01Clinical Trial Update: Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure (ACLF) Patients With Severe Coagulopathy [NA]
A clinical trial update describing ongoing recruitment for a study comparing two ROTEM-based thresholds for transfusing blood products befor…
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults [Phase 1]
Phase 1 clinical trial evaluating micro-encapsulated hepatocytes delivered intraperitoneally for adults with liver failure is currently recr…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Continuous Renal Replacement Therapy Intensity in Hyperammonemia [NA]
A clinical trial is evaluating the effect of different intensities of continuous renal replacement therapy on hyperammonemia in patients wit…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF) [Phase 1]
A Phase 1 trial assessing intravenous branched-chain amino acids for hepatic encephalopathy in patients with acute-on-chronic liver failure …
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients [NA]
This clinical trial update reports the completion of a study evaluating anti-fungal strategies in patients with acute-on-chronic liver failu…
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CLINICAL_TRIALS other · 2025-05-30Clinical Trial Update: Phase I Trial of QH-1A Hybrid Bio-Artificial Liver With Ex Vivo Blood-Purifying MSCs in Acute-on-Chronic Liver Failure [Phase 1]
Phase I trial of QH-1A Hybrid Bio-Artificial Liver with Ex Vivo Blood-Purifying MSCs for acute-on-chronic liver failure is listed as active …
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CLINICAL_TRIALS research · 2025-05-08Clinical Trial Update: Feasibility Pilot Study to Evaluate the Safety and Performance of the MEX-CD1 Medical Device in ACLF [NA]
Feasibility pilot trial to evaluate the safety and performance of the MEX-CD1 medical device in acute-on-chronic liver failure and multiple …
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CLINICAL_TRIALS research · 2025-04-22Clinical Trial Update: Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as a Prognostic Predictor Among Patients With Acute on Top of Chronic Liver Cell Failure
A clinical trial led by Assiut University is investigating whether neutrophil-to-lymphocyte ratio and mean platelet volume can serve as prog…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) Patients [Phase 2]
Phase II clinical trial of AS1501 for acute-on-chronic liver failure in China is currently not recruiting.
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CLINICAL_TRIALS trial_result · 2025-03-19Clinical Trial Update: Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating ACLF [Phase 2, Phase 3]
This clinical trial investigates umbilical cord-derived mesenchymal stem cell infusions for acute-on-chronic liver failure, spanning Phase 2…
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CLINICAL_TRIALS research · 2025-03-19Clinical Trial Update: A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial). [Phase 2]
Phase 2 clinical trial evaluating a combinatorial therapy using albumin and enoxaparin in patients with decompensated cirrhosis at high risk…
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CLINICAL_TRIALS research · 2025-03-10Clinical Trial Update: Single Cell Landscape of HBV-related Acute-on-chronic Liver Failure Patients
This clinical trial analyzes single-cell gene expression in patients with HBV-related acute-on-chronic liver failure to map immune and liver…
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CLINICAL_TRIALS research · 2025-02-25Clinical Trial Update: The Safety ,Tolerability and Efficacy Study of HepaCure in Chinese Subjects with Acute-On-Chronic Liver Failure [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial assessing the safety, tolerability, and preliminary efficacy of HepaCure in Chinese patients with acute-on-…
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CLINICAL_TRIALS research · 2025-02-20Clinical Trial Update: Study About Hepatic Toxins Kinetic and Evaluation of Organ Damage in Acute on Chronic Liver Failure (ACLF) Patients
An ongoing clinical trial evaluating hepatic toxins kinetics and organ damage in patients with acute on chronic liver failure (ACLF), curren…
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CLINICAL_TRIALS research · 2025-02-13Clinical Trial Update: MSC-EVs in Acute/ Acute-on-Chronic Liver Failure After Liver Transplantation [Phase 1]
A Phase 1 clinical trial entry evaluating mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) for acute liver failure and acute-o…
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CLINICAL_TRIALS research · 2025-02-10Clinical Trial Update: Comparison of Efficacy and Safety of Ceftazidime Avibactam Versus Extended Infusions of High Dose Meropenem in Patients of ACLF With Nosocomial Infections. [NA]
A clinical trial evaluating the efficacy and safety of ceftazidime-avibactam versus extended-infusion high-dose meropenem for nosocomial inf…
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CLINICAL_TRIALS research · 2025-02-07Clinical Trial Update: Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal Bleed [Phase 2, Phase 3]
A Phase 2/3 clinical trial comparing continuous infusion of terlipressin versus bolus terlipressin in patients with acute on chronic liver f…
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CLINICAL_TRIALS research · 2025-02-04Clinical Trial Update: Goal Directed Ammonia Lowering Therapy in Hyperammonemic ACLF Patients With no Overt HE to Reduce Major Adverse Liver Related Outcomes (GOAL Trial) [NA]
This document describes the GOAL Trial, a clinical study assessing an ammonia-lowering therapy in patients with acute-on-chronic liver failu…
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CLINICAL_TRIALS trial_result · 2025-01-22Clinical Trial Update: Utility of Liver and Splenic Stiffness in Predicting Esophageal Varices in Patients With Acute on Chronic Liver Failure
A completed clinical trial evaluated whether liver and splenic stiffness measurements can predict esophageal varices in patients with acute-…
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CLINICAL_TRIALS research · 2024-12-18Clinical Trial Update: Efficacy and Safety of BMSCs (CG-BM1) for ACLF Patients [Phase 1, Phase 2]
Clinical trial evaluating the efficacy and safety of BMSCs (CG-BM1) for acute-on-chronic liver failure, currently in Phase 1/2 and recruitin…