On Chronic Liver Failure
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CLINICAL_TRIALS trial_result · 2026-07-23Clinical Trial Results: Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)® [Phase 2]
Phase 2 trial evaluating VS-01 in adults with acute-on-chronic liver failure and ascites; study terminated with posted results.
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CLINICAL_TRIALS trial_result · 2026-06-04Clinical Trial Results: Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5% [Phase 3]
Phase 3 trial evaluating short-term survival of acute-on-chronic liver failure patients treated with plasma exchange using 5% human serum al…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Bidirectional Cohort Study of a Prognosis Model for Acute-on-chronic Liver Failure
A bidirectional cohort study is being conducted to develop a prognosis model for acute-on-chronic liver failure. The study status is ACTIVE_…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device. [Phase 3]
A Phase 3 clinical trial (NCT07347275) of DIALIVE 2.0, an extracorporeal liver dialysis device, for acute-on-chronic liver failure and liver…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced Coagulopathy [NA]
The document reports a completed clinical trial evaluating goal-directed hemostatic resuscitation for coagulopathy associated with acute-on-…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial) [NA]
This clinical trial entry describes a study called DPMAS-ACLF evaluating double plasma separation and adsorption in acute-on-chronic liver f…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial [NA]
A clinical trial protocol evaluating vitamin C for acute kidney injury in patients with acute-on-chronic liver failure and septic shock, cur…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Assessment of Changes in Bone Mineral Metabolism After Liver Transplantation by Bone Mineral Densitometry
A recruiting clinical trial is investigating how bone mineral metabolism changes after liver transplantation, assessed by bone mineral densi…
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 Trial [Phase 1]
Phase 1 trial of miroliverELAP for acute liver failure has been completed. The document provides an update on the trial status by Miromatrix…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: EGEN-5784 Porcine Liver With the Metra® ELC Device [Phase 1]
Phase 1 trial update for EGEN-5784 porcine liver with the Metra ELC device, evaluating use in acute-on-chronic liver failure and hepatic enc…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications in Acute-on-chronic Liver Failure. [NA]
A clinical trial is evaluating early initiation of midodrine to control and prevent ascites and related complications in patients with acute…
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: PT-MSCs Exosome Injection in the Treatment of Chronic-to-acute Liver Failure [EARLY_Phase 1]
Early-phase Phase 1 clinical trial update on PT-MSCs Exosome Injection for Acute-on-Chronic Liver Failure; the study is currently active but…
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CLINICAL_TRIALS trial_result · 2026-01-16Clinical Trial Update: Pharmacokinetic Study on G1090N (Nitazoxanide) Capsules in Healthy Volunteers [Phase 1]
Phase 1 pharmacokinetic study of G1090N (Nitazoxanide) capsules in healthy volunteers to characterize drug exposure. The trial is sponsored …
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CLINICAL_TRIALS trial_result · 2026-01-14Clinical Trial Update: Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)® [Phase 2]
Phase 2 study of VS-01 in adults with acute-on-chronic liver failure and ascites has been terminated. No further results are being reported …
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic Encephalopathy [Phase 2]
Genfit's Phase 2 trial of the investigational medicine VS-01 for hepatic encephalopathy in patients with acute-on-chronic liver failure and …
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLF [NA]
Clinical trial update on ALSS using DPMAS and therapeutic plasma exchange to assess effects on coagulation, inflammation and organ function …
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: The Effects of Double Plasma Molecular Adsorption System in Acute on Chronic Liver Failure Patients [NA]
This clinical trial update describes evaluating the Double Plasma Molecular Adsorption System in patients with acute-on-chronic liver failur…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis [NA]
Clinical trial evaluating the efficacy and safety of cytokine adsorption and plasma exchange in patients with acute-on-chronic liver failure…
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CLINICAL_TRIALS trial_result · 2025-12-16Clinical Trial Update: Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5% [Phase 3]
A Phase 3 trial evaluating plasma exchange with 5% human serum albumin for acute-on-chronic liver failure was terminated.
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Risk Factors Affecting MSC Efficacy in ACLF Patients
A clinical trial update examining factors that affect the efficacy of mesenchymal stem cell therapy in patients with acute-on-chronic liver …
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: F573 for Injection for the Treatment of Liver Injury/Failure [Phase 2]
Phase 2 clinical trial update for F573 for Injection in acute liver failure and acute-on-chronic liver failure, currently recruiting.
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
This clinical trial update discusses indications for liver transplantation in patients with cirrhosis and severe acute-on-chronic liver fail…
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: CytOSorb TreatMent Of Critically Ill PatientS Registry
A Clinical Trials registry update shows that CytoSorbents is recruiting for a registry trial evaluating Cytosorb hemoadsorption in criticall…
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CLINICAL_TRIALS trial_result · 2025-09-02Clinical Trial Update: Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension
This entry notes the completion of a clinical trial evaluating volume resuscitation in patients with cirrhosis and sepsis-induced hypotensio…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF) [Phase 1]
Phase I study evaluating mesenchymal stem-cell therapy for acute-on-chronic liver failure; currently not yet recruiting.