Acute Lymphoblastic Leukemia
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Sign up freeTop drugs studied for this disease
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FDA approval · 2017-03-07FDA Approved: METHOTREXATE — Supplemental Application (Fresenius Kabi USA, LLC)
The FDA approved a supplemental application for METHOTREXATE SODIUM from Fresenius Kabi USA, LLC.
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CLINICAL_TRIALS research · 2017-03-03Clinical Trial Update: Comparison Between Cyclophosphamide and Combination of Methotrexate + Calcineurin Inhibitor for GVHD Prophylaxis [Phase 3]
A Phase 3 trial comparing cyclophosphamide with methotrexate plus a calcineurin inhibitor for GVHD prophylaxis in patients with various hema…
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CLINICAL_TRIALS trial_result · 2017-02-28Clinical Trial Update: CART19 to Treat B-Cell Leukemia or Lymphoma That Are Resistant or Refractory to Chemotherapy [Phase 1]
Phase 1 trial evaluating CART19 therapy for B-cell hematologic malignancies including various lymphomas and leukemias that are refractory or…
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CLINICAL_TRIALS trial_result · 2017-02-27Clinical Trial Update: Study in Pediatrics With Relapsed or Refractory Pediatric Acute Lymphoblastic Leukemia (pALL) or Lymphoblastic Lymphoma [Phase 2]
Phase 2 pediatric trial for relapsed or refractory B-cell acute lymphoblastic leukemia or lymphoblastic lymphoma sponsored by MedImmune; the…
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CLINICAL_TRIALS trial_result · 2017-02-23Clinical Trial Update: A Dose Confirmation and Pharmacokinetic Study of Pegcrisantaspase Administered as Intravenous (IV) Infusion in Children and Young Adults With Acute Lymphoblastic Leukemia (ALL) /Lymphoblastic Lymphoma (LBL). Following Hypersensitivity to Pegaspargase (Oncaspar) [Phase 2]
Phase 2 dose confirmation and pharmacokinetic study of pegcrisantaspase given IV in children and young adults with acute lymphoblastic leuke…
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CLINICAL_TRIALS trial_result · 2017-02-20Clinical Trial Update: T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell Transplantation in Patients With Hematologic Malignancies Relapsed or Refractory Despite Previous Allogeneic Transplant [Phase 2]
Phase 2 trial of T-cell replete haploidentical donor hematopoietic stem cell transplantation with natural killer (NK) cell support in hemato…
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CLINICAL_TRIALS trial_result · 2017-02-15Clinical Trial Update: CD19 CAR T Cells for B Cell Malignancies After Allogeneic Transplant [Phase 1, Phase 2]
This update covers a phase 1/2 clinical trial evaluating CD19 CAR T cells for B-cell malignancies in patients after allogeneic transplantati…
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CLINICAL_TRIALS trial_result · 2017-02-10Clinical Trial Update: Allogeneic Cytokine-induced Killer Immunotherapy for Relapse After Allogeneic Marrow Transplant for Haematological Malignancies [Phase 1, Phase 2]
Phase 1 and Phase 2 results are reported for allogeneic cytokine-induced killer (CIK) cell immunotherapy given to patients who relapsed afte…
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CLINICAL_TRIALS trial_result · 2017-02-09Clinical Trial Update: Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission [Phase 3]
Phase 3 trial evaluating tacrolimus and methotrexate with or without sirolimus to prevent graft-versus-host disease in young patients underg…
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CLINICAL_TRIALS trial_result · 2017-02-09Clinical Trial Update: Study of the Glutaminase Inhibitor CB-839 in Leukemia [Phase 1]
This document provides a Phase 1 trial update for CB-839, a glutaminase inhibitor, in patients with acute myeloid leukemia and acute lymphob…
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CLINICAL_TRIALS trial_result · 2017-02-09Clinical Trial Update: Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia [Phase 3]
A Phase 3 clinical trial evaluating combination chemotherapy in children with newly diagnosed acute lymphoblastic leukemia has completed.
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CLINICAL_TRIALS trial_result · 2017-02-08Clinical Trial Update: Clinical Study With Blinatumomab in Pediatric and Adolescent Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
Update on a Phase 1/2 study of blinatumomab in children and adolescents with relapsed or refractory B-precursor acute lymphoblastic leukemia…
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CLINICAL_TRIALS trial_result · 2017-02-08Clinical Trial Update: The Effectiveness of the Neutropenic Diet in Pediatric Oncology Patients [NA]
A completed clinical trial evaluating the effectiveness of the neutropenic diet in pediatric oncology patients, including acute lymphoblasti…
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CLINICAL_TRIALS trial_result · 2017-02-03Clinical Trial Update: Glucarpidase Effect on Severe Delayed HDM-clearance in Children Treated With High-dose Mtx in ALL [Phase 3]
Phase 3 trial assessing glucarpidase impact on severe delayed HDM clearance in children with high-dose methotrexate-treated acute lymphoblas…
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CLINICAL_TRIALS trial_result · 2017-01-27Clinical Trial Update: Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma [Phase 2]
Phase 2 trial evaluating bortezomib in combination chemotherapy for relapsed acute lymphoblastic leukemia or lymphoblastic lymphoma in child…
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CLINICAL_TRIALS trial_result · 2017-01-25Clinical Trial Update: Study of SCH 900776 (MK-8776) With and Without Cytarabine in Participants With Acute Leukemias (P05247) [Phase 1]
Phase 1 study of SCH 900776 (MK-8776) with and without cytarabine in acute leukemias; the trial is terminated with posted results.
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CLINICAL_TRIALS trial_result · 2017-01-23Clinical Trial Update: CART-19 Cells For MRD Positive CD19+ ALL [Phase 2, Phase 3]
An update on CART-19 cell therapy for MRD-positive CD19+ acute lymphoblastic leukemia, conducted across Phase 2 and Phase 3. The sponsor is …
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CLINICAL_TRIALS trial_result · 2017-01-23Clinical Trial Update: Trial to Assess the Efficacy of a TCR Alfa Beta Depleted Graft in Pediatric Affected by ALL or AML and Receiving an HSCT [Phase 1, Phase 2]
The document reports the completion of a Phase 1/2 trial evaluating a TCR alpha-beta depleted graft in pediatric patients with acute lymphob…
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CLINICAL_TRIALS withdrawal · 2017-01-19Clinical Trial Update: Testing a Reduced Conditioning Regimen FB2A2 Preceded by a Fractionated Radio-immunotherapy (RIT) With 90Y-Epratuzumab Before Allogeneic Stem Cell Transplantation for Patients With Lymphocyte B CD22 Positive Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
This clinical trial update reports withdrawal of a Phase 1/2 study evaluating a reduced conditioning regimen with 90Y-epratuzumab radioimmun…
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CLINICAL_TRIALS research · 2017-01-16Clinical Trial Update: Optimizing 6-mercaptopurine Therapy in Pediatric Acute Lymphoblastic Leukemia by Using Allopurinol [Phase 2]
Phase 2 clinical trial exploring optimization of 6-mercaptopurine therapy for pediatric acute lymphoblastic leukemia using allopurinol.
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CLINICAL_TRIALS trial_result · 2016-12-29Clinical Trial Update: Home-exercise Program for Children and Adolescent Survivors of Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
The clinical trial update notes the completion of a Phase 1/Phase 2 study evaluating a home-exercise program for children and adolescents wh…
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CLINICAL_TRIALS trial_result · 2016-12-28Clinical Trial Update: Biomarker To Evaluate Protein Profiles of Neutropenic Fever/Infection With Acute or Chronic Leukemias
This completed clinical trial investigates protein biomarker profiles in neutropenic fever/infection among patients with acute or chronic le…
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FDA approval · 2016-12-20FDA Approved: TREXALL — Supplemental Application (Teva Women's Health, Inc.)
FDA approved a supplemental application for TREXALL (methotrexate) from Teva Women's Health, Inc.
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CLINICAL_TRIALS research · 2016-12-15Clinical Trial Update: Design and Evaluation of Care Environment and Technology at Pediatric Radiotherapy
This clinical trial update from Umeå University reports on the design and evaluation of the care environment and technology used in pediatri…
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CLINICAL_TRIALS withdrawal · 2016-12-15Clinical Trial Update: Volasertib and Vincristine Sulfate Liposome in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia [Phase 1]
A Phase 1 trial combining volasertib with vincristine sulfate liposome for relapsed or refractory adult acute lymphoblastic leukemia was wit…