Systemic Sclerosis

• CLINICAL_TRIALS trial_result · 2021-05-04
  Clinical Trial Update: A Clinical Study to Test How Effective and Safe GLPG1690 is for Participants With Systemic Sclerosis [Phase 2]

  Phase 2 clinical trial evaluating the safety and effectiveness of GLPG1690 in systemic sclerosis has completed with posted results.

• CLINICAL_TRIALS trial_result · 2021-04-05
  Clinical Trial Update: Systemic Sclerosis (SSc) Vasculopathy: Improved Clinical Monitoring and Treatment [Phase 1, Phase 2]

  Phase 1/2 trial update on systemic sclerosis vasculopathy reporting completed status with results posted.

• CLINICAL_TRIALS trial_result · 2020-11-02
  Clinical Trial Update: Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan [Phase 4]

  Phase 4 trial updating exercise-induced pulmonary hypertension in systemic sclerosis and treatment with ambrisentan.

• CLINICAL_TRIALS trial_result · 2020-10-08
  Clinical Trial Update: Injection of Autologous Adipose-derived Stromal Vascular Fraction in the Finger of Systemic Sclerosis Patients [EARLY_Phase 1]

  Early Phase 1 trial assessing autologous adipose-derived stromal vascular fraction injections for finger involvement in systemic sclerosis; …

• CLINICAL_TRIALS trial_result · 2020-08-12
  Clinical Trial Update: Cardiac Safe Transplants for Systemic Sclerosis [Phase 2, Phase 3]

  Clinical trial update for a cardiac-safe transplant approach in systemic sclerosis/scleroderma completed phases 2 and 3; status terminated w…

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• CLINICAL_TRIALS trial_result · 2020-07-23
  Clinical Trial Update: Autologous Stem Cell Systemic Sclerosis Immune Suppression Trial [Phase 3]

  Phase 3 trial of autologous stem cell systemic sclerosis immune suppression has been terminated; results posted in 2020.

• CLINICAL_TRIALS withdrawal · 2020-06-30
  Clinical Trial Update: Intraoperative ICG for Systemic Sclerosis [Phase 4]

  Phase 4 clinical trial investigating intraoperative ICG for systemic sclerosis has been withdrawn.

• CLINICAL_TRIALS trial_result · 2020-05-15
  Clinical Trial Update: Safety Of Fat Micrografts With Adipose-Derived Stromal Vascular Fraction In Hands Of Patients With Systemic Sclerosis [Phase 2]

  Phase 2 clinical trial evaluating the safety of fat micrografts with adipose-derived stromal vascular fraction for hands in patients with sy…

• CLINICAL_TRIALS trial_result · 2020-05-14
  Clinical Trial Update: Effect and Safety of Local Injection of Botulinum Toxin Type B Against Digital Ulcer in Systemic Sclerosis [Phase 2]

  Phase 2 trial evaluating local injection of Botulinum toxin Type B for digital ulcers in systemic sclerosis; study completed.

• CLINICAL_TRIALS trial_result · 2020-05-08
  Clinical Trial Update: Evaluation of Tofacitinib in Early Diffuse Cutaneous Systemic Sclerosis (dcSSc) [Phase 1, Phase 2]

  Phase 1/2 clinical trial evaluating tofacitinib for early diffuse cutaneous systemic sclerosis (dcSSc) has completed with results posted.

• CLINICAL_TRIALS trial_result · 2020-04-30
  Clinical Trial Update: Early Treatment of Borderline Pulmonary Arterial Hypertension Associated With Systemic Sclerosis (SSc-APAH) [Phase 2]

  Phase 2 trial update on early treatment of borderline pulmonary arterial hypertension associated with systemic sclerosis (SSc-APAH); study c…

• CLINICAL_TRIALS research · 2020-04-29
  Clinical Trial Update: The Effect of a Home-based Orofacial Exercise Program on Oral Aperture of Systemic Sclerosis Patients [NA]

  A completed clinical trial evaluated a home-based orofacial exercise program for improving oral aperture in patients with microstomia due to…

• CLINICAL_TRIALS trial_result · 2020-04-10
  Clinical Trial Update: Treprostinil Iontophoresis in Systemic Sclerosis Digital UlcErations. A Proof of Concept Study [Phase 1, Phase 2]

  A phase 1/2 proof-of-concept trial evaluating treprostinil delivered via iontophoresis for systemic sclerosis-related digital ulcers has com…

• CLINICAL_TRIALS trial_result · 2020-02-18
  Clinical Trial Update: A Study of the Efficacy and Safety of Rituximab in Participants With Systemic Sclerosis [Phase 2, Phase 3]

  A phase 2/3 clinical trial evaluating the efficacy and safety of rituximab in participants with systemic sclerosis (scleroderma) and related…

• CLINICAL_TRIALS trial_result · 2020-02-12
  Clinical Trial Update: The Scleroderma Patient-centered Intervention Network (SPIN) Support Group Leader Education Program Feasibility Trial [NA]

  Feasibility trial evaluating a leader education program for scleroderma support groups; study completed with results posted.

• CLINICAL_TRIALS trial_result · 2019-12-13
  Clinical Trial Update: A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis [Phase 3]

  Phase 3 trial comparing nintedanib to placebo in scleroderma-related lung fibrosis completed; results posted in 2019.

• CLINICAL_TRIALS trial_result · 2019-10-18
  Clinical Trial Update: Study of Pomalidomide (CC-4047) to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effectiveness for Patients With Systemic Sclerosis With Interstitial Lung Disease [Phase 2]

  Phase 2 trial evaluating pomalidomide (CC-4047) for systemic sclerosis with interstitial lung disease was terminated; results posted in 2019…

• CLINICAL_TRIALS trial_result · 2019-09-24
  Clinical Trial Update: Riociguat in Scleroderma Associated Digital Ulcers [Phase 2]

  A Phase 2 trial update on riociguat for digital ulcers associated with scleroderma has completed, with results posted in 2019.

• CLINICAL_TRIALS trial_result · 2019-08-15
  Clinical Trial Update: Taking Charge of Systemic Sclerosis [NA]

  Clinical trial update for systemic sclerosis (scleroderma) with completed status and posted results.

• CLINICAL_TRIALS trial_result · 2019-07-30
  Clinical Trial Update: Effectiveness of Saccharomyces Boulardii for Gastrointestinal Bacterial-overgrowth in Systemic Sclerosis [Phase 4]

  Phase 4 clinical trial evaluating the effectiveness of Saccharomyces boulardii for gastrointestinal bacterial overgrowth in systemic scleros…

• CLINICAL_TRIALS trial_result · 2019-07-05
  Clinical Trial Update: Scleroderma ARFI Imaging of the Skin

  Clinical trial update on ARFI imaging of the skin in scleroderma has completed with results posted.

• CLINICAL_TRIALS trial_result · 2019-04-03
  Clinical Trial Update: A Study of the Efficacy and Safety of Tocilizumab in Participants With Systemic Sclerosis (SSc) [Phase 3]

  Phase 3 trial update on efficacy and safety of tocilizumab in systemic sclerosis has completed with results posted.

• CLINICAL_TRIALS trial_result · 2019-03-13
  Clinical Trial Update: Gut Microbiota Transplantation in Systemic Sclerosis [Phase 1, Phase 2]

  Clinical trial update on gut microbiota transplantation for systemic sclerosis (scleroderma) across Phase 1 and Phase 2, status completed.

• CLINICAL_TRIALS trial_result · 2019-01-25
  Clinical Trial Update: Efficacy and Safety of Riociguat in Patients With Systemic Sclerosis [Phase 2]

  Phase 2 clinical trial evaluating riociguat for systemic sclerosis has completed; results posted in 2019 with data on efficacy and safety.

• CLINICAL_TRIALS trial_result · 2018-12-13
  Clinical Trial Update: The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis [Phase 4]

  A Phase 4 clinical trial assessing the effects of bosentan on arterial stiffness in patients with systemic sclerosis (scleroderma).