Systemic Sclerosis
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CLINICAL_TRIALS trial_result · 2026-08-13Clinical Trial Results: TENS in Scleroderma [NA]
Completed clinical trial results for TENS in scleroderma (systemic sclerosis) and gastroparesis, posted in 2026.
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CLINICAL_TRIALS trial_result · 2026-04-22Clinical Trial Update: Nitric Oxide Lung Diffusing Capacity in Systemic Sclerosis
This clinical trial update notes that the study on nitric oxide lung diffusing capacity in systemic sclerosis has completed.
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: Infusion of Allogeneic Stromal Mesenchymal Stem Cells From Wharton´s Jelly in Patients With Diffuse Cutaneous Systemic Sclerosis With Refractory Pulmonary Involvement to Treatment [Phase 1, Phase 2]
The document reports the completion of a Phase 1/2 clinical trial evaluating intravenous infusion of allogeneic mesenchymal stem cells deriv…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: Hyaluronidase Via LADD Scleroderma-induced Microstomia [EARLY_Phase 1]
Early-phase clinical trial investigating hyaluronidase delivered via LADD for microstomia in scleroderma has completed.
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: Study to Evaluate the Safety, Tolerability, and Activity of CM-101 in Patients With Systemic Sclerosis [Phase 2]
A Phase 2 trial evaluating CM-101 for systemic sclerosis has been suspended.
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: In Vivo Endomicroscopic Description of Pulmonary Microcirculation in Systemic Sclerosis and Emphysema Patients [NA]
The trial NCT02556697 investigated in vivo endomicroscopic imaging of pulmonary microcirculation in patients with systemic sclerosis and emp…
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: Safety and Preliminary Efficacy of HN2302 in Patients With Autoimmune Diseases [Phase 1]
Phase 1 clinical trial update on HN2302 assessing safety and preliminary efficacy in autoimmune diseases, including systemic lupus erythemat…
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CLINICAL_TRIALS trial_result · 2026-04-03Clinical Trial Update: Laser Treatment for the Improvement of Scars and Scleroderma [NA]
A laser treatment trial for improving scars and systemic sclerosis was terminated, with results posted on 2026-04-03 by Massachusetts Genera…
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: Pilot Study to Evaluate the Interest of PDL in the Management of Telangiectasia of the Face and Neckline in Systemic Scleroderma [NA]
A pilot study evaluating Pulsed Dye Laser (PDL) for treating facial telangiectasia in systemic sclerosis has completed.
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: MRI Quantification of Pulmonary Fibrosis in Scleroderma Patients [NA]
A completed clinical trial evaluating MRI-based quantification of pulmonary fibrosis in patients with systemic sclerosis (scleroderma) to as…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Conception of an ICF Core Set for Systemic Sclerosis
This clinical trial update describes the development of an International Classification of Functioning Core Set for systemic sclerosis, with…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Auto-immunity and Pulmonary Arterial Hypertension [NA]
Status update indicating a trial on auto-immunity and pulmonary arterial hypertension sponsored by Assistance Publique - Hôpitaux de Paris i…
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CLINICAL_TRIALS trial_result · 2026-03-25Clinical Trial Update: Phase IIa Trial of Anti-CD19 CAR T-Cells in Systemic Sclerosis Resistant to Immunosuppressive Therapy [Phase 2]
This update announces a Phase IIa clinical trial evaluating anti-CD19 CAR T-cell therapy for systemic sclerosis resistant to immunosuppressi…
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis [Phase 4]
A Phase 4 trial comparing upfront autologous hematopoietic stem cell transplantation to immunosuppression in early diffuse cutaneous systemi…
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CLINICAL_TRIALS trial_result · 2026-03-20Clinical Trial Update: A Multicenter Trial to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of HZN-825 in Patients With Diffuse Cutaneous Systemic Sclerosis [Phase 2]
A Phase 2 multicenter trial assessing HZN-825 in diffuse cutaneous systemic sclerosis has been terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2026-03-17Clinical Trial Update: A Study in People With Systemic Sclerosis to Test Whether Avenciguat (BI 685509) Has an Effect on Lung Function and Other Systemic Sclerosis Symptoms [Phase 2]
Phase 2 study in systemic sclerosis evaluating Avenciguat (BI 685509) for effects on lung function and other symptoms; the trial status is c…
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CLINICAL_TRIALS trial_result · 2026-03-16Clinical Trial Update: Efficacy of Tofacitinib on Skin Thickening in Diffuse Cutaneous Systemic Sclerosis: A Comparative Study With Methotrexate [Phase 4]
Phase 4 trial evaluating the efficacy of tofacitinib on skin thickening in diffuse cutaneous systemic sclerosis, compared with methotrexate;…
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CLINICAL_TRIALS trial_result · 2026-03-11Clinical Trial Update: Effects of a Personalized Standardized Rehabilitation Program in Systemic Sclerosis [NA]
A clinical trial evaluating a personalized standardized rehabilitation program for systemic sclerosis has completed. This update notes the s…
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CLINICAL_TRIALS trial_result · 2026-02-13Clinical Trial Update: An Open-label, Phase 2 Study to Assess the Efficacy and Safety of Nemolizumab in Subjects With Systemic Sclerosis [Phase 2]
An open-label Phase 2 study evaluating the efficacy and safety of nemolizumab in systemic sclerosis has completed. Results have been posted.
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CLINICAL_TRIALS trial_result · 2026-02-11Clinical Trial Update: Self-Guided Resilience-Building Energy Management to Enhance Well-being (RENEW) Intervention for People With Systemic Sclerosis (SSc) [NA]
ClinicalTrials.gov indicates the RENEW trial, evaluating a self-guided resilience-building energy management intervention for people with sy…
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CLINICAL_TRIALS trial_result · 2026-02-03Clinical Trial Update: Clinical Study on Targeted CD19CAR-T Therapy for Autoimmune Diseases [EARLY_Phase 1]
A Phase 1 targeted CD19 CAR-T therapy trial for autoimmune diseases has been suspended.
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CLINICAL_TRIALS trial_result · 2026-01-14Clinical Trial Update: the Safety and Efficacy of Targeted BCMA In Vivo LV Injection for Recurrent or Refractory Autoimmune Diseases [EARLY_Phase 1]
An early Phase 1 clinical trial evaluating the safety and efficacy of a targeted BCMA in vivo lentiviral vector injection for recurrent or r…
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CLINICAL_TRIALS trial_result · 2026-01-13Clinical Trial Update: A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1) [Phase 1]
Phase 1 Breakfree-1 trial evaluating CC-97540, a CD-19-targeted Nex-T CAR T cell therapy, for severe, refractory autoimmune diseases; the st…
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CLINICAL_TRIALS trial_result · 2026-01-08Clinical Trial Update: Efficacy and Safety of Allogenic Cultured Adipose-derived Mesenchymal Stromal Cell Injections on MoUth Fibrosis and Handicap in Patients With Systemic sclEroderma [Phase 2]
Phase 2 clinical trial evaluating allogeneic cultured adipose-derived mesenchymal stromal cell injections for mouth fibrosis and handicap in…
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CLINICAL_TRIALS trial_result · 2026-01-06Clinical Trial Update: Yoga Adjunct for Scleroderma [NA]
A completed clinical trial evaluating yoga as an adjunct therapy for systemic sclerosis (scleroderma).