Soft Tissue Sarcoma
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CLINICAL_TRIALS research · 2024-08-26Clinical Trial Update: RNASARC - Molecular Screening Program of Soft Tissue Sarcomas With Complex Genomic Profile to Detect NTRK1/2/3, ROS1 or ALK Gene Fusions. [NA]
A molecular screening trial (RNASARC) for soft tissue sarcomas to detect NTRK1/2/3, ROS1 or ALK gene fusions; the study is currently active …
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CLINICAL_TRIALS withdrawal · 2024-08-15Clinical Trial Update: Fluorescent Aided Resection and Evaluation of Soft Tissue Sarcomas (FLARES) [Phase 1]
Phase 1 trial FLARES investigating fluorescence-guided resection for soft tissue sarcoma has been withdrawn.
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CLINICAL_TRIALS trial_result · 2024-08-13Clinical Trial Update: Trial of Sunitinib and/or Nivolumab Plus Chemotherapy in Advanced Soft Tissue and Bone Sarcomas [Phase 1, Phase 2]
A completed Phase 1/2 trial evaluating sunitinib and/or nivolumab with chemotherapy in advanced soft tissue and bone sarcomas.
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CLINICAL_TRIALS research · 2024-08-13Clinical Trial Update: Safety and Efficacy of Degradable Magnesium Metal Clips in Surgical Margins of Radical Surgery for Malignant Bone and Soft Tissue Tumors [NA]
The document summarizes a clinical trial evaluating the safety and efficacy of degradable magnesium alloy surgical clips used at surgical ma…
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CLINICAL_TRIALS research · 2024-08-13Clinical Trial Update: Pemigatinib and Immune Checkpoint Inhibitor Treated FGFR1/2/3 Alteration Advanced Solid Tumor [Phase 2]
Phase 2 clinical trial update on pemigatinib plus an immune checkpoint inhibitor for FGFR1/2/3-altered advanced solid tumors; the study is n…
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CLINICAL_TRIALS research · 2024-08-12Clinical Trial Update: Anlotinib Combined With Doxorubicin and Radiotherapy as Neoadjuvant Treatment for Soft Tissue Sarcoma [Phase 4]
A Phase 4 clinical trial evaluating neoadjuvant therapy with Anlotinib combined with Doxorubicin and radiotherapy for soft tissue sarcoma; r…
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CLINICAL_TRIALS research · 2024-07-30Clinical Trial Update: Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma [NA]
A clinical trial compares chest CT versus chest X-ray for lung surveillance after curative-intent resection of high-risk truncal-extremity s…
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CLINICAL_TRIALS trial_result · 2024-07-23Clinical Trial Update: Pembrolizumab and Radiation Therapy in Treating Patients With Intermediate or High-Grade Soft Tissue Sarcoma [Phase 1, Phase 2]
Clinical trial update for pembrolizumab with radiation therapy in intermediate- or high-grade soft tissue sarcoma (Phase 1/2). The study has…
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CLINICAL_TRIALS research · 2024-07-23Clinical Trial Update: Clinical Trial of VIM With VIT in Children With Relapsed and Refractory Soft Tissue Sarcoma. [Phase 2]
A Phase 2 clinical trial evaluating the VIM with VIT regimen is underway in children with relapsed and refractory soft tissue sarcoma. The s…
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CLINICAL_TRIALS withdrawal · 2024-07-17Clinical Trial Update: Brightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue Sarcoma [Phase 3]
A Phase 3 trial (Brightline-3) testing brigimadlin in combination with ezabenlimab for advanced soft tissue sarcoma, including undifferentia…
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CLINICAL_TRIALS research · 2024-07-15Clinical Trial Update: TQB2916 Injection Combined With Chemotherapy or Penpulimab Injection in the Treatment of Solid Tumors [Phase 2]
Clinical trial update describing a Phase 2 study of TQB2916 injection in combination with chemotherapy or Penpulimab for solid tumors, inclu…
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CLINICAL_TRIALS trial_result · 2024-07-08Clinical Trial Update: Low Dose Continuous Cyclophosphamide vs Standard Doxorubicin in Advanced Sarcoma Elderly Patients [Phase 3]
A Phase 3 study comparing low-dose continuous cyclophosphamide to standard doxorubicin in elderly patients with advanced soft tissue sarcoma…
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CLINICAL_TRIALS research · 2024-07-05Clinical Trial Update: LINNOVATE: Lurbinectedin, Ipilimumab and Nivolumab for Soft Tissue Sarcoma [Phase 1, Phase 2]
A Phase 1/2 clinical trial (LINNOVATE) is evaluating a triple combination of lurbinectedin, ipilimumab, and nivolumab for advanced soft tiss…
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CLINICAL_TRIALS trial_result · 2024-07-03Clinical Trial Update: Dendritic Cell Vaccine for Children and Adults With Sarcoma [Phase 1]
This Phase 1 trial update reports the completion of a dendritic cell vaccine study in children and adults with soft tissue and bone sarcoma.
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CLINICAL_TRIALS trial_result · 2024-06-18Clinical Trial Update: Theranostics in Soft Tissue Sarcoma Using a Vascular Disruption Approach [Phase 1]
Phase 1 trial evaluating a vascular disruption theranostic approach for soft tissue sarcoma has completed.
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CLINICAL_TRIALS trial_result · 2024-06-13Clinical Trial Update: Phase 3 Study to Treat Patients With Soft Tissue Sarcomas [Phase 3]
Phase 3 study in metastatic, locally advanced or unresectable soft tissue sarcoma completed; results were posted in June 2024.
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CLINICAL_TRIALS trial_result · 2024-06-12Clinical Trial Update: Lymphodepletion Plus Adoptive Cell Therapy With High Dose IL-2 in Adolescent and Young Adult Patients With Soft Tissue Sarcoma [Phase 1]
A Phase 1 trial evaluating lymphodepletion followed by adoptive cell therapy with high-dose interleukin-2 in adolescent and young adult pati…
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CLINICAL_TRIALS research · 2024-06-07Clinical Trial Update: A Platform of Patient Derived Xenografts (PDX) and 2D/3D Cell Cultures of Soft Tissue Sarcomas (STS) [NA]
This clinical trial profile from The Netherlands Cancer Institute describes a platform using patient-derived xenografts and 2D/3D cell cultu…
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CLINICAL_TRIALS research · 2024-05-31Clinical Trial Update: Genomic Risk in Retroperitoneal Sarcoma
A clinical trial update announcing ongoing recruitment for a study investigating genomic risk in retroperitoneal sarcoma, sponsored by Fox C…
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CLINICAL_TRIALS trial_result · 2024-05-29Clinical Trial Update: Preliminary Efficacy and Safety of INNO-206 Compared to Doxorubicin in Advanced Soft Tissue Sarcoma [Phase 2]
Phase 2 trial comparing INNO-206 to doxorubicin in advanced soft tissue sarcoma reports preliminary efficacy and safety results.
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CLINICAL_TRIALS trial_result · 2024-05-29Clinical Trial Update: Study to Investigate the Safety and Activity of Aldoxorubicin Plus Ifosfamide/Mesna in Subjects With Metastatic Soft Tissue Sarcoma [Phase 1, Phase 2]
A completed Phase 1/Phase 2 trial evaluating aldoxorubicin in combination with ifosfamide/Mesna for metastatic, unresectable soft tissue sar…
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CLINICAL_TRIALS research · 2024-05-21Clinical Trial Update: A Study of ILB2109 and Toripalimab in Patients With Advanced Solid Malignancies [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating ILB2109 in combination with toripalimab in patients with advanced solid malignancies, currently recrui…
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FDA label_change · 2024-05-20FDA Approved: PAZOPANIB — Supplemental Application (Apotex Corp.)
FDA approved a supplemental application for pazopanib by Apotex Corp. (ANDA 217713), likely involving labeling or other post-approval change…
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CLINICAL_TRIALS withdrawal · 2024-05-16Clinical Trial Update: Camsirubicin + Pegfilgrastim to Determine MTD in ASTS [Phase 1]
Phase 1 trial of Camsirubicin plus Pegfilgrastim to determine the maximum tolerated dose in advanced soft-tissue sarcoma has been terminated…
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CLINICAL_TRIALS trial_result · 2024-05-14Clinical Trial Update: PBI-MST-01 (NCT04541108) Substudy MSD-03: Intratumoral Microdosing of Pembrolizumab Alone and With MK-0482 or MK-4830 in HNSCC or STS [EARLY_Phase 1]
An early-phase trial evaluating intratumoral microdosing of pembrolizumab alone or with MK-0482 or MK-4830 in head and neck squamous cell ca…