Soft Tissue Sarcoma
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: Study to Assess TOPO2A as a Biomarker for Sensitivity to Doxorubicin/Doxil in Soft Tissue Sarcoma
The document describes a clinical trial investigating TOPO2A as a biomarker of sensitivity to doxorubicin and Doxil in soft tissue sarcoma. …
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FDA approval · 2024-12-04FDA Approved: PAZOPANIB — Original Application (Aurobindo Pharma Limited)
FDA approved Aurobindo Pharma Limited's pazopanib ANDA 219034, a generic version of pazopanib. It is indicated for unresectable or metastati…
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CLINICAL_TRIALS trial_result · 2024-11-25Clinical Trial Update: Lenvatinib and Eribulin in Advanced Soft Tissue Sarcoma [Phase 1, Phase 2]
Phase 1/2 study evaluating lenvatinib and eribulin in advanced soft tissue sarcoma has completed with posted results. The study includes lei…
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CLINICAL_TRIALS research · 2024-11-25Clinical Trial Update: A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08) [Phase 1, Phase 2]
GI Innovation's GI-102 is being studied in a phase 1/2 trial as a single agent and in combination with pembrolizumab or trastuzumab deruxtec…
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CLINICAL_TRIALS research · 2024-11-22Clinical Trial Update: Surveillance AFter Extremity Tumor surgerY [NA]
A McMaster University-sponsored clinical trial investigating soft tissue sarcoma with lung metastases is currently active but not recruiting…
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CLINICAL_TRIALS research · 2024-11-21Clinical Trial Update: ARTEMIS-103: Phase 1b Study of HS-20093 Combinations in Patients with Bone and Soft Tissue Sarcoma. [Phase 1]
A Phase 1b trial (ARTEMIS-103) evaluates HS-20093 in patients with bone and soft tissue sarcoma, and the study is currently not recruiting.
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CLINICAL_TRIALS research · 2024-11-19Clinical Trial Update: First-line Treatment of Advanced/unresectable DDLPS [Phase 2]
This clinical trial update outlines a Phase 2 first-line treatment study for advanced or unresectable dedifferentiated liposarcoma (DDLPS) a…
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CLINICAL_TRIALS withdrawal · 2024-11-18Clinical Trial Update: Neoadjuvant Lurbinectedin and Preoperative Radiation for Treating Soft Tissue Sarcomas [Phase 1, Phase 2]
Phase 1/2 trial of neoadjuvant lurbinectedin with preoperative radiation for locally advanced soft tissue sarcoma has been withdrawn.
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FDA approval · 2024-11-08FDA Approved: PAZOPANIB — Supplemental Application (SUN PHARMACEUTICAL INDUSTRIES, INC.)
FDA approved a supplemental application for pazopanib from Sun Pharmaceutical Industries, Inc. (ANDA 215837).
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CLINICAL_TRIALS trial_result · 2024-11-08Clinical Trial Update: Navtemadlin and Radiation Therapy in Treating Patients With Soft Tissue Sarcoma [Phase 1]
Phase 1 trial evaluating navtemadlin with radiation therapy for soft tissue sarcoma; results posted.
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CLINICAL_TRIALS trial_result · 2024-11-04Clinical Trial Update: Neoadjuvant Durvalumab and Tremelimumab Plus Radiation for High Risk Soft-Tissue Sarcoma [Phase 1, Phase 2]
The clinical trial evaluating neoadjuvant durvalumab and tremelimumab in combination with radiation for high-risk soft tissue sarcoma has be…
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CLINICAL_TRIALS research · 2024-11-01Clinical Trial Update: Chemo-immunotherapy in Patients Under 18 Years of Age With Bone and Soft Tissue Sarcomas [Phase 3]
A Phase 3 clinical trial registry entry describing a chemo-immunotherapy study in patients under 18 with bone sarcoma and soft tissue sarcom…
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CLINICAL_TRIALS trial_result · 2024-10-31Clinical Trial Update: Cemiplimab for Secondary Angiosarcomas [Phase 2]
This report indicates the completion of a Phase 2 trial evaluating cemiplimab for secondary angiosarcoma and related locally advanced or met…
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CLINICAL_TRIALS trial_result · 2024-10-28Clinical Trial Update: A Study of CCT301-59 CAR T Therapy in Adult Subjects With Recurrent or Refractory Solid Tumors [Phase 1]
Phase 1 trial of CCT301-59 CAR T therapy in adults with recurrent or refractory solid tumors has been terminated. The study included soft ti…
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CLINICAL_TRIALS research · 2024-10-26Clinical Trial Update: A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors [Phase 2]
Phase 2 trial of AdAPT-001 in patients with sarcoma and refractory solid tumors is currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-10-24Clinical Trial Update: Study of Liposomal Annamycin for the Treatment of Subjects with Soft-Tissue Sarcomas (STS) with Pulmonary Metastases [Phase 1, Phase 2]
This clinical trial update reports a Phase 1/2 study of liposomal annamycin for soft-tissue sarcoma with pulmonary metastases. The study sta…
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CLINICAL_TRIALS trial_result · 2024-10-23Clinical Trial Update: A Study of Olaratumab (LY3012207) Plus Pembrolizumab in Participants With Advanced or Metastatic Soft Tissue Sarcoma [Phase 1]
A Phase 1 study of olaratumab (LY3012207) plus pembrolizumab in advanced or metastatic soft tissue sarcoma has completed and posted results.
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CLINICAL_TRIALS trial_result · 2024-10-21Clinical Trial Update: Study of the Safety, Pharmacokinetics and Efficacy of Tinostamustine in Patients With Advanced Solid Tumors. [Phase 1, Phase 2]
Clinical trial update reporting safety, pharmacokinetics, and efficacy findings for tinostamustine in patients with advanced solid tumors, i…
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CLINICAL_TRIALS research · 2024-10-16Clinical Trial Update: High Versus Lower Intensity Surveillance Following Resection of Retroperitoneal Sarcoma [Phase 3]
Phase 3 trial comparing high- versus lower-intensity surveillance after resection of retroperitoneal soft tissue sarcoma; sponsored by Fonda…
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CLINICAL_TRIALS research · 2024-10-15Clinical Trial Update: Phase II Clinical Trial of Chidamide Combined With AK112 for Second-line and Advanced Bone and Soft Tissue Sarcoma [Phase 2]
Phase II clinical trial evaluating chidamide in combination with AK112 for second-line and advanced soft tissue and bone sarcoma. Recruitmen…
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CLINICAL_TRIALS research · 2024-10-15Clinical Trial Update: A Study of LVGN6051 Combined with Anlotinib in Patient with Soft Tissue Sarcoma [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/2 study of LVGN6051 in combination with Anlotinib for soft tissue sarcoma, currently recruiti…
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: A Phase II Study on Adjuvant Vaccination with Dendritic Cells Loaded with Autologous Tumor Homogenate in Resected Stage IV Rare Cancers. [Phase 2]
Phase II trial evaluating dendritic cells loaded with autologous tumor homogenate as adjuvant vaccination in resected stage IV rare cancers;…
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CLINICAL_TRIALS withdrawal · 2024-09-19Clinical Trial Update: TAS-116 Plus Palbociclib in Breast and Rb-null Cancer [Phase 1]
A Phase 1 trial investigating TAS-116 in combination with palbociclib for advanced breast cancer and RB-deficient solid tumors has been with…
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CLINICAL_TRIALS trial_result · 2024-09-04Clinical Trial Update: Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 Pediatric MATCH trial evaluating samotolisib in pediatric patients with relapsed or refractory tumors harboring TSC or PI3K/mTOR mut…
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CLINICAL_TRIALS trial_result · 2024-08-29Clinical Trial Update: A Study Of Naxitamab , Granulocyte Macrophage Colony Stimulating Factor For Patients With Relapsed /Refractory , Soft Tissue or Anti GD2 Immunotherapy Refractory Neuroblastoma [Phase 2]
Phase 2 study of naxitamab in combination with GM-CSF for relapsed/refractory neuroblastoma and anti-GD2 immunotherapy-refractory soft tissu…