Septic Shock
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2018-07-06Clinical Trial Update: Bloodstream Infection Due to Multidrug-Resistant Organisms - Multicenter Study on Determinants of Clinical Outcomes
This update describes a multicenter observational study investigating determinants of clinical outcomes in bloodstream infections caused by …
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CLINICAL_TRIALS trial_result · 2018-07-05Clinical Trial Update: Effects of Endotoxin in Normal Human Volunteers [Phase 1]
Phase 1 clinical trial examining physiological responses to endotoxin exposure in healthy volunteers. It also notes conditions including lun…
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CLINICAL_TRIALS trial_result · 2018-06-13Clinical Trial Update: Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients [Phase 4]
Phase 4 clinical trial comparing phenylephrine versus norepinephrine for septic shock in critically ill patients; the trial was terminated w…
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CLINICAL_TRIALS research · 2018-06-06Clinical Trial Update: Does Urinary TIMP2 and IGFBP7 Can Identify High Risk Patients of Progression From Mild and Moderate to Severe Acute Kidney Injury During Septic Shock?
This clinical trial update investigates whether urinary TIMP2 and IGFBP7 biomarkers can identify patients with septic shock and early acute …
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CLINICAL_TRIALS trial_result · 2018-05-30Clinical Trial Update: High Strong Ion Difference Fluid vs Hartmann's Solution on Acid-Base Status in Sepsis [NA]
A completed clinical trial comparing High Strong Ion Difference Fluid to Hartmann's Solution assessed effects on acid-base status in sepsis.
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CLINICAL_TRIALS trial_result · 2018-05-24Clinical Trial Update: Effects on Microcirculation of IgGAM in Severe Septic/Septic Shock Patients. [Phase 2]
Phase 2 trial evaluating the effects of IgGAM on microcirculation in patients with sepsis and septic shock has completed. The study was spon…
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CLINICAL_TRIALS trial_result · 2018-05-18Clinical Trial Update: Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients [Phase 3]
Phase 3 trial comparing vasopressin to norepinephrine for septic shock in cancer patients has completed.
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CLINICAL_TRIALS withdrawal · 2018-05-17Clinical Trial Update: Effect of a Continuous Infusion of Esmolol on Stroke Volume in Patients With Hyperdynamic Vasoplegic Septic Shock [Phase 3]
Phase 3 trial evaluating a continuous infusion of esmolol to affect stroke volume in hyperdynamic vasoplegic septic shock has been withdrawn…
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CLINICAL_TRIALS trial_result · 2018-05-02Clinical Trial Update: Microcirculatory Oxygen Uptake in Sepsis
This clinical trial update reports that the study on microcirculatory oxygen uptake in patients with sepsis, severe sepsis, and septic shock…
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CLINICAL_TRIALS trial_result · 2018-04-24Clinical Trial Update: Immunglobulin M Enriched Intra Venous Immunoglobulin (IVIG) Therapy in Adult Respiratory Distress Syndrom (ARDS) Patients
A completed clinical trial evaluated immunoglobulin M-enriched intravenous immunoglobulin therapy in adults with acute respiratory distress …
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CLINICAL_TRIALS trial_result · 2018-04-18Clinical Trial Update: Observational Study on Intubation in Septic Shock
An observational trial evaluating intubation in patients with septic shock; the study has completed.
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CLINICAL_TRIALS trial_result · 2018-04-06Clinical Trial Update: Hemofiltration in Burns: RESCUE (Randomized Controlled Evaluation of Hemofiltration in Adult Burn Patients With Septic Shock and Acute Renal Failure) [NA]
An update on the RESCUE randomized trial evaluating hemofiltration in adult burn patients with septic shock and acute kidney injury.
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CLINICAL_TRIALS trial_result · 2018-04-05Clinical Trial Update: Lactated Ringer Versus Albumin in Early Sepsis Therapy [Phase 3]
A Phase 3 trial evaluating Lactated Ringer's solution versus Albumin for early sepsis therapy has completed, involving patients with septic …
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CLINICAL_TRIALS trial_result · 2018-03-29Clinical Trial Update: Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock [NA]
The trial evaluated interventions to minimize fluid administration in ICU patients with septic shock, with results posted in 2018.
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CLINICAL_TRIALS trial_result · 2018-03-27Clinical Trial Update: Adsorbtion of Cytokines Early in Septic Shock: the ACESS Study
The ACESS study evaluating early cytokine adsorption in septic shock has completed.
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CLINICAL_TRIALS trial_result · 2018-03-13Clinical Trial Update: The Effect of Erythropietin on Microcircualtory Alteration in Intensive Care Unit Patients With Severe Sepsis
A clinical trial evaluating erythropoietin for microcirculatory alterations in ICU patients with severe sepsis has been terminated.
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CLINICAL_TRIALS trial_result · 2018-03-08Clinical Trial Update: Changes in Microvascular Perfusion During Blood Purification With Cytosorb® in Septic Shock
This clinical trial update reports changes in microvascular perfusion during blood purification with Cytosorb in septic shock, and the study…
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CLINICAL_TRIALS trial_result · 2018-03-07Clinical Trial Update: ASSET - a Double-Blind, Randomized Placebo-Controlled Clinical Investigation With Alteco® LPS Adsorber [NA]
The ASSET trial evaluating the Alteco LPS adsorber for septic shock has been terminated.
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CLINICAL_TRIALS research · 2018-03-06Clinical Trial Update: Reversibility of Diastolic Disfunction in Septic Shock
An update on a clinical trial investigating whether diastolic dysfunction observed in septic shock can be reversed.
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CLINICAL_TRIALS trial_result · 2018-02-14Clinical Trial Update: Early Warning System for Clinical Deterioration on General Hospital Wards [NA]
Clinical trial completed evaluating an early warning system for deterioration on general hospital wards; results posted in 2018.
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CLINICAL_TRIALS trial_result · 2018-01-31Clinical Trial Update: Effect of Different Strategies for Titrating a High MAP on Microcirculation [Phase 4]
Phase 4 clinical trial evaluating different strategies for titrating a high mean arterial pressure on microcirculation in septic shock and h…
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CLINICAL_TRIALS trial_result · 2018-01-30Clinical Trial Update: Evaluating in Cirrhotics With Refractory Vasoplegia the Effect of Methylene Blue [Phase 4]
Phase 4 trial evaluating methylene blue for refractory vasoplegia in cirrhotics with septic shock has completed.
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CLINICAL_TRIALS trial_result · 2018-01-24Clinical Trial Update: Effect of Dexmedetomidine on Perfusion Index and Microcirculation in Severe Sepsis and Septic Shock Patients [Phase 3]
Phase 3 clinical trial update examining dexmedetomidine effects on perfusion index and microcirculation in patients with septic shock.
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CLINICAL_TRIALS trial_result · 2018-01-09Clinical Trial Update: Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock Trial. VIPER-Sepsis (EudraCT no. 2016-000707-81) [Phase 4]
Phase 4 trial investigating vasculopathic injury and plasma as endothelial rescue in septic shock (VIPER-Sepsis) was terminated.
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FDA approval · 2017-12-21FDA Approved: GIAPREZA — Original Application (La Jolla Pharmaceutical Company)
GIAPREZA (angiotensin II) was approved to increase blood pressure in adults with septic or other distributive shock.