Septic Shock
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CLINICAL_TRIALS trial_result · 2019-02-06Clinical Trial Update: Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock [NA]
Clinical trial update on the safety and efficacy of Polymyxin B hemoperfusion for septic shock, with completed status and results posted.
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CLINICAL_TRIALS research · 2019-02-06Clinical Trial Update: Usefulness of Capillary Refill Time and Skin Mottling Score to Predict Intensive Care Unit Admission
This clinical trial update evaluates whether capillary refill time and the skin mottling score can predict ICU admission in patients with se…
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CLINICAL_TRIALS trial_result · 2019-01-31Clinical Trial Update: Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock
This clinical trial update reports on vasopressin plasma concentrations in septic shock patients receiving an exogenous vasopressin infusion…
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CLINICAL_TRIALS research · 2019-01-29Clinical Trial Update: Quantification of Bacterial DNA in Sepsis
This entry reports on a clinical trial studying quantification of bacterial DNA in patients with sepsis and septic shock; the current status…
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CLINICAL_TRIALS trial_result · 2019-01-16Clinical Trial Update: Angiotensin II for Septic Shock Treatment [Phase 3]
Phase 3 trial evaluating Angiotensin II for septic shock was suspended.
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CLINICAL_TRIALS trial_result · 2019-01-09Clinical Trial Update: Esmolol Infusion for Patients With Septic Shock and Persistent Tachycardia [Phase 2]
Phase 2 clinical trial update evaluating esmolol infusion for patients with septic shock and persistent tachycardia; study completed with re…
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CLINICAL_TRIALS trial_result · 2018-12-12Clinical Trial Update: Dexmedetomidine on Microcirculation in Septic Shock [Phase 4]
Phase 4 clinical trial evaluating dexmedetomidine effects on microcirculation in septic shock has completed.
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CLINICAL_TRIALS trial_result · 2018-11-29Clinical Trial Update: Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock [Phase 4]
Phase 4 trial evaluating effects of levosimendan, milrinone, and norepinephrine on left and right ventricular function in septic shock, with…
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CLINICAL_TRIALS trial_result · 2018-11-29Clinical Trial Update: Evaluation of Early Association of Terlipressin and Norepinephrine During Septic Shock; the TerliNor Study [Phase 4]
Phase 4 clinical trial evaluating early association of terlipressin and norepinephrine in septic shock (TerliNor study).
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CLINICAL_TRIALS trial_result · 2018-11-21Clinical Trial Update: Shenfu Injection Improves Arterial Vascular Reactivity [Phase 2, Phase 3]
Phase 2/3 trial updates suggest Shenfu Injection may improve arterial vascular reactivity in septic shock.
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CLINICAL_TRIALS trial_result · 2018-11-21Clinical Trial Update: Lidocaine as an Adjuvant for Ketamine in Induction of Anesthesia in Septic Shock Patients [Phase 3]
Phase 3 trial update investigating lidocaine as an adjuvant to ketamine for induction of anesthesia in septic shock patients; current status…
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FDA approval · 2018-11-07FDA Approved: NOREPINEPHRINE BITARTRATE — Original Application (Hikma Pharmaceuticals USA Inc.)
FDA approved Hikma Pharmaceuticals USA Inc.'s generic norepinephrine bitartrate injection (Original Application) as a vasopressor for treati…
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CLINICAL_TRIALS trial_result · 2018-10-23Clinical Trial Update: Control Versus Liberal Cardiac Frequency in Patients in Sepse With Atrial Fibrillation of High Ventricular Response [Phase 3]
Phase 3 clinical trial comparing control versus liberal heart rate strategies in septic patients with atrial fibrillation and high ventricul…
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FDA approval · 2018-10-04FDA Approved: NOREPINEPHRINE BITARTRATE — Original Application (Mylan Institutional LLC)
FDA approved Mylan Institutional LLC's original application for norepinephrine bitartrate injections (generic) as a vasopressor to treat lif…
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CLINICAL_TRIALS trial_result · 2018-08-29Clinical Trial Update: Fluids in Sepsis and Septic Shock [Phase 2, Phase 3]
Phase 2/3 clinical trial update on fluids used for sepsis and septic shock; status completed.
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CLINICAL_TRIALS trial_result · 2018-08-29Clinical Trial Update: What Should be the Next Vasopressor for Severe Septic Shock? Methylene Blue or Terlipressin [Phase 3]
Phase 3 clinical trial comparing methylene blue versus terlipressin as vasopressors for severe septic shock is ongoing; current status is un…
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CLINICAL_TRIALS trial_result · 2018-08-22Clinical Trial Update: Transpulmonary Thermodilution and Transesophageal Echocardiography in Early Septic Shock [Phase 4]
Phase 4 clinical trial update evaluating transpulmonary thermodilution and transesophageal echocardiography in patients with septic shock ha…
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CLINICAL_TRIALS trial_result · 2018-08-16Clinical Trial Update: Treatment of Severe Infection With Antihyperlipidemia Drug [Phase 2, Phase 3]
Clinical trial update for an antihyperlipidemia drug being tested for severe infection in Phase 2/Phase 3.
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CLINICAL_TRIALS trial_result · 2018-08-09Clinical Trial Update: A Study of LJPC-501 in Paediatric Patients With Hypotension Associated With Distributive or Vasodilatory Shock [Phase 2]
A Phase 2 clinical trial update for LJPC-501 in pediatric patients with hypotension related to distributive or vasodilatory shock, including…
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CLINICAL_TRIALS trial_result · 2018-08-06Clinical Trial Update: Terlipressin Alone Versus the Standard Therapy With Catecholamines for Hepatic Patients With Septic Shock- Prospective Single Center Randomized Controlled Study. [Phase 2, Phase 3]
Prospective single-center randomized trial comparing terlipressin alone to standard catecholamine therapy for hepatic patients with septic s…
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CLINICAL_TRIALS trial_result · 2018-07-23Clinical Trial Update: Early Goal Directed Therapy Using a Physiological Holistic View. The ANDROMEDA-SHOCK Study [NA]
The ANDROMEDA-SHOCK study evaluating early goal-directed therapy guided by peripheral perfusion in septic shock has completed.
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CLINICAL_TRIALS research · 2018-07-18Clinical Trial Update: Application of Biomarkers Change to Predict Outcome of Patient With Severe Sepsis
This clinical trial update describes a study on applying biomarker changes to predict outcomes in patients with severe sepsis.
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CLINICAL_TRIALS trial_result · 2018-07-16Clinical Trial Update: Echo vs. EGDT in Severe Sepsis and Septic Shock [NA]
A completed clinical trial comparing echocardiography-guided management (Echo) with early goal-directed therapy (EGDT) in patients with seve…
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CLINICAL_TRIALS trial_result · 2018-07-10Clinical Trial Update: Ketamine Versus Low Dose Thiopental for Induction of Anesthesia in Septic Shock [Phase 3]
A Phase 3 trial comparing ketamine to low-dose thiopental for induction of anesthesia in septic shock has completed.
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CLINICAL_TRIALS trial_result · 2018-07-06Clinical Trial Update: Mortality Reduction in Septic Shock by Plasma Adsorption [NA]
A terminated clinical trial evaluating plasma adsorption therapy reported mortality reduction in patients with septic shock.